Why Experts Can't Agree on Whether AI Has a Mind Pillay is an editorial fellow at TIME. Pillay is an editorial fellow at TIME. I'm not used to getting nasty emails from a holy man, says Professor Michael Levin, a developmental biologist at Tufts University. Levin was presenting his research to a group of engineers interested in spiritual matters in India, arguing that properties like "mind" and intelligence can be observed even in cellular systems, and that they exist on a spectrum. But when he pushed further--arguing that the same properties emerge everywhere, including in computers--the reception shifted.

Neural Cellular Automata (NCA) represent a powerful framework for modeling biological self-organization, extending classical rule-based systems with trainable, differentiable (or evolvable) update rules that capture the adaptive self-regulatory dynamics of living matter. By embedding Artificial Neural Networks (ANNs) as local decision-making centers and interaction rules between localized agents, NCA can simulate processes across molecular, cellular, tissue, and system-level scales, offering a multiscale competency architecture perspective on evolution, development, regeneration, aging, morphogenesis, and robotic control. These models not only reproduce biologically inspired target patterns but also generalize to novel conditions, demonstrating robustness to perturbations and the capacity for open-ended adaptation and reasoning. Given their immense success in recent developments, we here review current literature of NCAs that are relevant primarily for biological or bioengineering applications. Moreover, we emphasize that beyond biology, NCAs display robust and generalizing goal-directed dynamics without centralized control, e.g., in controlling or regenerating composite robotic morphologies or even on cutting-edge reasoning tasks such as ARC-AGI-1. In addition, the same principles of iterative state-refinement is reminiscent to modern generative Artificial Intelligence (AI), such as probabilistic diffusion models. Their governing self-regulatory behavior is constraint to fully localized interactions, yet their collective behavior scales into coordinated system-level outcomes. We thus argue that NCAs constitute a unifying computationally lean paradigm that not only bridges fundamental insights from multiscale biology with modern generative AI, but have the potential to design truly bio-inspired collective intelligence capable of hierarchical reasoning and control.

Understanding and manipulating bioelectric signaling could present a new wave of progress in developmental biology, regenerative medicine, and synthetic biology. Bioelectric signals, defined as voltage gradients across cell membranes caused by ionic movements, play a role in regulating crucial processes including cellular differentiation, proliferation, apoptosis, and tissue morphogenesis. Recent studies demonstrate the ability to modulate these signals to achieve controlled tissue regeneration and morphological outcomes in organisms such as planaria and frogs. However, significant knowledge gaps remain, particularly in predicting and controlling the spatial and temporal dynamics of membrane potentials (V_mem), understanding their regulatory roles in tissue and organ development, and exploring their therapeutic potential in diseases. In this work we propose an experiment using Deep Reinforcement Learning (DRL) framework together with lab automation techniques for real-time manipulation of bioelectric signals to guide tissue regeneration and morphogenesis. The proposed framework should interact continuously with biological systems, adapting strategies based on direct biological feedback. Combining DRL with real-time measurement techniques -- such as optogenetics, voltage-sensitive dyes, fluorescent reporters, and advanced microscopy -- could provide a comprehensive platform for precise bioelectric control, leading to improved understanding of bioelectric mechanisms in morphogenesis, quantitative bioelectric models, identification of minimal experimental setups, and advancements in bioelectric modulation techniques relevant to regenerative medicine and cancer therapy. Ultimately, this research aims to utilize bioelectric signaling to develop new biomedical and bioengineering applications.

When your mailbag brims with 25,000 letters and emails every day, deciding which to answer first is daunting. When lurking within are pleas for help from some of the country's most vulnerable people, the stakes only get higher. That is the challenge facing the Department for Work and Pensions (DWP) as correspondence floods in from benefit applicants and claimants – of which there are more than 20 million, including pensioners, in the UK. The DWP thinks it may have found a solution in using artificial intelligence to read it all first – including handwritten missives. Human reading used to take weeks and could leave the most vulnerable people waiting for too long for help.

Traditionally, cognition has been considered a uniquely human capability involving perception, memory, learning, reasoning, and problem-solving. However, recent research shows that cognition is a fundamental ability shared by all living beings, from single cells to complex organisms. This chapter takes an info-computational approach (ICON), viewing natural structures as information and the processes of change in these structures as computations. It is a relational framework dependent on the perspective of a cognizing observer/cognizer. Informational structures are properties of the material substrate, and when focusing on the behavior of the substrate, we discuss morphological computing (MC). ICON and MC are complementary perspectives for a cognizer. Information and computation are inseparably connected with cognition. This chapter explores research connecting nature as a computational structure for a cognizer, with morphological computation, morphogenesis, agency, extended cognition, and extended evolutionary synthesis, using examples of the free energy principle and active inference. It introduces theoretical and practical approaches challenging traditional computational models of cognition limited to abstract symbol processing, highlighting the computational capacities inherent in the material substrate (embodiment). Understanding the embodiment of cognition through its morphological computational basis is crucial for biology, evolution, intelligence theory, AI, robotics, and other fields.

This study aims to place Lorenzo Magnanis Eco-Cognitive Computationalism within the broader context of current work on information, computation, and cognition. Traditionally, cognition was believed to be exclusive to humans and a result of brain activity. However, recent studies reveal it as a fundamental characteristic of all life forms, ranging from single cells to complex multicellular organisms and their networks. Yet, the literature and general understanding of cognition still largely remain human-brain-focused, leading to conceptual gaps and incoherency. This paper presents a variety of computational (information processing) approaches, including an info-computational approach to cognition, where natural structures represent information and dynamical processes on natural structures are regarded as computation, relative to an observing cognizing agent. We model cognition as a web of concurrent morphological computations, driven by processes of self-assembly, self-organisation, and autopoiesis across physical, chemical, and biological domains. We examine recent findings linking morphological computation, morphogenesis, agency, basal cognition, extended evolutionary synthesis, and active inference. We establish a connection to Magnanis Eco-Cognitive Computationalism and the idea of computational domestication of ignorant entities. Novel theoretical and applied insights question the boundaries of conventional computational models of cognition. The traditional models prioritize symbolic processing and often neglect the inherent constraints and potentialities in the physical embodiment of agents on different levels of organization. Gaining a better info-computational grasp of cognitive embodiment is crucial for the advancement of fields such as biology, evolutionary studies, artificial intelligence, robotics, medicine, and more.

Diffusion Models represent a significant advancement in generative modeling, employing a dual-phase process that first degrades domain-specific information via Gaussian noise and restores it through a trainable model. This framework enables pure noise-to-data generation and modular reconstruction of, images or videos. Concurrently, evolutionary algorithms employ optimization methods inspired by biological principles to refine sets of numerical parameters encoding potential solutions to rugged objective functions. Our research reveals a fundamental connection between diffusion models and evolutionary algorithms through their shared underlying generative mechanisms: both methods generate high-quality samples via iterative refinement on random initial distributions. By employing deep learning-based diffusion models as generative models across diverse evolutionary tasks and iteratively refining diffusion models with heuristically acquired databases, we can iteratively sample potentially better-adapted offspring parameters, integrating them into successive generations of the diffusion model. This approach achieves efficient convergence toward high-fitness parameters while maintaining explorative diversity. Diffusion models introduce enhanced memory capabilities into evolutionary algorithms, retaining historical information across generations and leveraging subtle data correlations to generate refined samples. We elevate evolutionary algorithms from procedures with shallow heuristics to frameworks with deep memory. By deploying classifier-free guidance for conditional sampling at the parameter level, we achieve precise control over evolutionary search dynamics to further specific genotypical, phenotypical, or population-wide traits. Our framework marks a major heuristic and algorithmic transition, offering increased flexibility, precision, and control in evolutionary optimization processes.

In the present work we use maximum entropy methods to derive several theorems in probabilistic number theory, including a version of the Hardy-Ramanujan Theorem. We also provide a theoretical argument explaining the experimental observations of Yang-Hui He about the learnability of primes, and posit that the Erd\H{o}s-Kac law would very unlikely be discovered by current machine learning techniques. Numerical experiments that we perform corroborate our theoretical findings.

The emerging field of Diverse Intelligence seeks to identify, formalize, and understand commonalities in behavioral competencies across a wide range of implementations. Especially interesting are simple systems that provide unexpected examples of memory, decision-making, or problem-solving in substrates that at first glance do not appear to be complex enough to implement such capabilities. We seek to develop tools to help understand the minimal requirements for such capabilities, and to learn to recognize and predict basal forms of intelligence in unconventional substrates. Here, we apply novel analyses to the behavior of classical sorting algorithms, short pieces of code which have been studied for many decades. To study these sorting algorithms as a model of biological morphogenesis and its competencies, we break two formerly-ubiquitous assumptions: top-down control (instead, showing how each element within a array of numbers can exert minimal agency and implement sorting policies from the bottom up), and fully reliable hardware (instead, allowing some of the elements to be "damaged" and fail to execute the algorithm). We quantitatively characterize sorting activity as the traversal of a problem space, showing that arrays of autonomous elements sort themselves more reliably and robustly than traditional implementations in the presence of errors. Moreover, we find the ability to temporarily reduce progress in order to navigate around a defect, and unexpected clustering behavior among the elements in chimeric arrays whose elements follow one of two different algorithms. The discovery of emergent problem-solving capacities in simple, familiar algorithms contributes a new perspective to the field of Diverse Intelligence, showing how basal forms of intelligence can emerge in simple systems without being explicitly encoded in their underlying mechanics.

Embodiment has recently enjoyed renewed consideration as a means to amplify the faculties of smart machines. Proponents of embodiment seem to imply that optimizing for movement in physical space promotes something more than the acquisition of niche capabilities for solving problems in physical space. However, there is nothing in principle which should so distinguish the problem of action selection in physical space from the problem of action selection in more abstract spaces, like that of language. Rather, what makes embodiment persuasive as a means toward higher intelligence is that it promises to capture, but does not actually realize, contingent facts about certain bodies (living intelligence) and the patterns of activity associated with them. These include an active resistance to annihilation and revisable constraints on the processes that make the world intelligible. To be theoretically or practically useful beyond the creation of niche tools, we argue that "embodiment" cannot be the trivial fact of a body, nor its movement through space, but the perpetual negotiation of the function, design, and integrity of that body--that is, to participate in what it means to constitute a given body. It follows that computer programs which are strictly incapable of traversing physical space might, under the right conditions, be more embodied than a walking, talking robot. The accomplishments of artificial intelligence are legion.