You're viewing the US edition You can switch to the UK or AU homepage at any time using this menu. Trump's CIA chief John Ratcliffe makes surprise trip to Moscow for secret meeting amid grim fears for Poland Hoover Dam's horror threat to 40 million Americans: As'tipping point' is reached... expert warns residents in THREE states to brace There's only one way Harry and Meghan's new royal life in Britain can work... and she's going to hate it: ROBERT JOBSON The photos that sparked wild internet rumours: James Blunt mingles with Hayden Panettiere on a yacht in 2009 after he broke his silence on claims he was the'British singer' who the late actress was put into bed with aged 18 Lindsay Clancy's lawyer clashes with witness as tensions reach fever pitch after exploding at reporter outside: Live updates Vanity Fair journalist covering Lindsay Clancy trial sparks outrage for SMILING on camera as she says'I'm proud of myself' in face of backlash ALEXANDRA SHULMAN: Emotionally battered, physically scarred... and I've put on weight. But I'm still in my bikini at 68, and this is why you should follow my lead Hollywood's nepo babies take over Vanity Fair's best dressed list: North West, Beyoncé's eldest Blue Ivy and Meryl Streep's daughter land top spots Your next new car could cost up to $6,000 more if President Trump's 50% tariff on Canada goes into effect Brand-new penis enlargement technique increased this man's size by a THIRD in just 45 minutes... he bares all and reveals results that've left him thrilled The 10-cent supplement that turbocharges your Mounjaro AND reduces your cholesterol: Most patients won't have heard of it, but now experts reveal why anyone on jabs must take it - and how it can stop you putting weight back on Renters rejoice as feds put an end to Zillow's $100M plot to neuter rival Redfin and eliminate rental market competition Brian Hickerson's dark family secrets outed by his own sister... who reveals moment his'demons' took over... and real reason Hayden Panettiere kept going back Woke Boston mayor goes on fever-pitched hunt to track down and threaten business owners renting parking spots to ICE agents in her city: 'This is unhinged' Lawyers for Anna Kepner's stepbrother make desperate bid to delay murder trial as they grapple with'unique and very unfortunate' evidence into Carnival cruise death Prince Harry and Meghan are'not the same people who left' and'relate to Britain differently', says Omid Scobie I left a sexless marriage at 54. Now, I'm having the time of my life with men in their 20s and 30s. This is what they all love about me...and why I'll still keep having our sleepovers in hotel rooms The Bible describes Jesus' burial place as a tomb carved into rock, set inside a garden near where he was crucified. For nearly 1,700 years, Christians have believed that tomb lies within Jerusalem's Church of the Holy Sepulchre.

How likely is a Yellowstone'supervolcano' eruption today? Don't cancel your trip just yet. More information Adding us as a Preferred Source in Google by using this link indicates that you would like to see more of our content in Google News results. Is this what it would actually look like? Breakthroughs, discoveries, and DIY tips sent six days a week. By signing up, you confirm you are 16+, will receive newsletters and promotional content and agree to our Terms of Use and acknowledge the data practices in our Privacy Policy . Picture this: You're roaming Yellowstone National Park as the ground begins to rumble, pressure builds, and then KA-BOOM! The last Yellowstone explosion happened 661,000 years ago, but could it happen again?

Follow this section to personalize your feed and get instant alerts. Follow Go to your personalized feed WHY FOLLOW? Smart Alerts: Get notified about major news as it happens. Follow this tag to personalize your feed and get instant alerts. Follow Go to your personalized feed WHY FOLLOW?

As we climbed the winding road to Bédar, we emerged into a charred and desolate landscape. Molten car parts littered our path and out of the window we saw the whole hillside now coated in a dusty black. At least 13 people, including five believed to be Britons, were killed by Thursday's wildfire in Spain's Almeria province, one of the country's deadliest ever. The toll rose on Sunday after a 93-year-old woman, believed to be British, died of her injuries in hospital. The identities of those killed have not yet been officially confirmed.

Understanding the geometry of neural network loss landscapes is a central question in deep learning, with implications for generalization and optimization. A striking phenomenon is linear mode connectivity (LMC), where independently trained models can be connected by low-or zero-barrier paths, despite appearing to lie in separate loss basins. However, this is often obscured by symmetries in parameter space--such as neuron permutations--which make functionally equivalent models appear dissimilar. Prior work has predominantly focused on neuron reordering through permutations, but such approaches are limited in scope and fail to capture the richer symmetries exhibited by modern architectures such as Transformers. In this work, we introduce a unified framework that captures four symmetry classes--permutations, semi-permutations, orthogonal transformations, and general invertible maps--broadening the set of valid reparameterizations and subsuming many previous approaches as special cases. Crucially, this generalization enables, for the first time, the discovery of low-and zero-barrier linear interpolation paths between independently trained Vision Transformers and GPT-2 models. Furthermore, our framework extends beyond pairwise alignment, to multi-model and width-heterogeneous settings, enabling alignment across architectures of different sizes. These results reveal deeper structure in the loss landscape and underscore the importance of symmetry-aware analysis for understanding model space geometry. Our code is available here.

A.1 Equations for Conformational Energy Landscape Overlap Analysis To quantify the similarity between the protein conformations generated by AI-based models and those in the ProteinConformers dataset, the following three commonly used overlap metrics are employed: Interaction overlap, coverage, and the Jaccard index. These metrics evaluate the extent of agreement in low-energy regions between the protein conformers from different models of the same protein, based on a specified energy threshold. Let A = {Ai,j} and B = {Bi,j} where i,j [0,N], denote the two-dimensional free energy landscapes corresponding of two conformational ensembles. Each element Ai,j and Bi,j represents the free energy value at a specific grid point in the conformational energy landscape. For a given energy threshold τ (e.g., 40 kJ/mol), the number of shared low-energy conformations is defined as: |A B| = Figure 6: Comparison of conformational landscapes for protein T1030, generated by ProteinConformers and protein conformation generative models.

The function of biomolecules such as proteins depends on their ability to interconvert between a wide range of structures or "conformations." Researchers have endeavored for decades to develop computational methods to predict the distribution of conformations, which is far harder to determine experimentally than a static folded structure. We present ConforMix, an inference-time algorithm that enhances sampling of conformational distributions using a combination of classifier guidance, filtering, and free energy estimation. Our approach upgrades diffusion models--whether trained for static structure prediction or conformational generation--to enable more efficient discovery of conformational variability without requiring prior knowledge of major degrees of freedom. ConforMix is orthogonal to improvements in model pretraining and would benefit even a hypothetical model that perfectly reproduced the Boltzmann distribution. Remarkably, when applied to a diffusion model trained for static structure prediction, ConforMix captures structural changes including domain motion, cryptic pocket flexibility, and transporter cycling, while avoiding unphysical states. Case studies of biologically critical proteins demonstrate the scalability, accuracy, and utility of this method.

In-silico prediction of protein mutant stability, measured by the difference in Gibbs free energy change ( G), is fundamental for protein engineering. Current sequence-to-label methods typically employ the two-stage pipeline: (i) encoding mutant sequences using neural networks (e.g., transformers), followed by (ii) the G regression from the latent representations. Although these methods have demonstrated promising performance, their dependence on specialized neural network encoders significantly increases the complexity. Additionally, the requirement to individually compute latent representations for each mutant site negatively impacts computational efficiency and poses the risk of overfitting. This work proposes the Venus-MAXWELL framework, which reformulates mutation G prediction as a sequence-to-landscape task. In Venus-MAXWELL, mutations of a protein and their corresponding Gvalues are organized into a landscape matrix, allowing our framework to learn the G landscape of a protein with a single forward and backward pass during training. Besides, to facilitate future works, we also curated a large-scale G dataset with strict controls on data leakage and redundancy to ensure robust evaluation. Venus-MAXWELL is compatible with multiple protein language models and enables these models for accurate and efficient G prediction. For example, when integrated with the ESM-IF, Venus-MAXWELL achieves higher accuracy than ThermoMPNN with 10 faster in inference speed (despite having 50 more parameters than ThermoMPNN).

Designing protein sequences of both high fitness and novelty is a challenging task in data-efficient protein engineering. Exploration beyond wild-type neighborhoods often leads to biologically implausible sequences or relies on surrogate models that lose fidelity in novel regions. Here, we propose PROSPERO, an active learning framework in which a frozen pre-trained generative model is guided by a surrogate updated from oracle feedback. By integrating fitness-relevant residue selection with biologically-constrained Sequential Monte Carlo sampling, our approach enables exploration beyond wild-type neighborhoods while preserving biological plausibility. We show that our framework remains effective even when the surrogate is misspecified. PROSPERO consistently outperforms or matches existing methods across diverse protein engineering tasks, retrieving sequences of both high fitness and novelty.

Stochastic optimal control methods often struggle in complex non-convex landscapes, frequently becoming trapped in local optima due to their inability to learn from historical trajectory data. This paper introduces Memory-Augmented Potential Field Theory, a unified mathematical framework that integrates historical experience into stochastic optimal control. Our approach dynamically constructs memory-based potential fields that identify and encode key topological features of the state space, enabling controllers to automatically learn from past experiences and adapt their optimization strategy. We provide a theoretical analysis showing that memory-augmented potential fields possess non-convex escape properties, asymptotic convergence characteristics, and computational efficiency. We implement this theoretical framework in a Memory-Augmented Model Predictive Path Integral (MPPI) controller that demonstrates significantly improved performance in challenging non-convex environments. The framework represents a generalizable approach to experience-based learning within control systems (especially robotic dynamics), enhancing their ability to navigate complex state spaces without requiring specialized domain knowledge or extensive offline training.