This paper presents a convolutional neural network model for precipitation nowcasting that combines data-driven learning with physics-informed domain knowledge. We propose LUPIN, a Lagrangian Double U-Net for Physics-Informed Nowcasting, that draws from existing extrapolation-based nowcasting methods and implements the Lagrangian coordinate system transformation of the data in a fully differentiable and GPU-accelerated manner to allow for real-time end-to-end training and inference. Based on our evaluation, LUPIN matches and exceeds the performance of the chosen benchmark, opening the door for other Lagrangian machine learning models.