Intracortical brain-computer interfaces (iBCIs) have allowed people with tetraplegia to control a computer cursor by imagining the movement of their paralyzed arm or hand. State-of-the-art decoders deployed in human iBCIs are derived from a Kalman filter that assumes Markov dynamics on the angle of intended movement, and a unimodal dependence on intended angle for each channel of neural activity. Due to errors made in the decoding of noisy neural data, as a user attempts to move the cursor to a goal, the angle between cursor and goal positions may change rapidly. We propose a dynamic Bayesian network that includes the on-screen goal position as part of its latent state, and thus allows the person's intended angle of movement to be aggregated over a much longer history of neural activity. This multiscale model explicitly captures the relationship between instantaneous angles of motion and long-term goals, and incorporates semi-Markov dynamics for motion trajectories. We also introduce a multimodal likelihood model for recordings of neural populations which can be rapidly calibrated for clinical applications. In offline experiments with recorded neural data, we demonstrate significantly improved prediction of motion directions compared to the Kalman filter. We derive an efficient online inference algorithm, enabling a clinical trial participant with tetraplegia to control a computer cursor with neural activity in real time. The observed kinematics of cursor movement are objectively straighter and smoother than prior iBCI decoding models without loss of responsiveness.

BMI applications, ranging from speech production to finger control.

This paper examines learning the optimal filtering policy, known as the Kalman gain, for a linear system with unknown noise covariance matrices using noisy output data. The learning problem is formulated as a stochastic policy optimization problem, aiming to minimize the output prediction error. This formulation provides a direct bridge between data-driven optimal control and, its dual, optimal filtering.

Many practical settings call for the reconstruction of temporal signals from corrupted or missing data. Classic examples include decoding, tracking, signal enhancement and denoising.

We study a distributionally robust mean square error estimation problem over a nonconvexWasserstein ambiguity set containing only normal distributions.

Brain-computer interfaces (BCIs) have enabled prosthetic device control by decoding motor movements from neural activities.