Machine learning shows remarkable success for recognizing patterns in data. Here we apply the machine learning (ML) for the diagnosis of early stage diabetes, which is known as a challenging task in medicine. Blood glucose levels are tightly regulated by two counter-regulatory hormones, insulin and glucagon, and the failure of the glucose homeostasis leads to the common metabolic disease, diabetes mellitus. It is a chronic disease that has a long latent period the complicates detection of the disease at an early stage. The vast majority of diabetics result from that diminished effectiveness of insulin action. The insulin resistance must modify the temporal profile of blood glucose. Thus we propose to use ML to detect the subtle change in the temporal pattern of glucose concentration. Time series data of blood glucose with sufficient resolution is currently unavailable, so we confirm the proposal using synthetic data of glucose profiles produced by a biophysical model that considers the glucose regulation and hormone action. Multi-layered perceptrons, convolutional neural networks, and recurrent neural networks all identified the degree of insulin resistance with high accuracy above $85\%$.

In this paper, we develop a novel procedure for low-rank tensor regression, namely \underline{I}mportance \underline{S}ketching \underline{L}ow-rank \underline{E}stimation for \underline{T}ensors (ISLET). The central idea behind ISLET is \emph{importance sketching}, i.e., carefully designed sketches based on both the responses and low-dimensional structure of the parameter of interest. We show that the proposed method is sharply minimax optimal in terms of the mean-squared error under low-rank Tucker assumptions and under randomized Gaussian ensemble design. In addition, if a tensor is low-rank with group sparsity, our procedure also achieves minimax optimality. Further, we show through numerical studies that ISLET achieves comparable or better mean-squared error performance to existing state-of-the-art methods whilst having substantial storage and run-time advantages including capabilities for parallel and distributed computing. In particular, our procedure performs reliable estimation with tensors of dimension $p = O(10^8)$ and is $1$ or $2$ orders of magnitude faster than baseline methods.

Scientists have reversed diabetes in mice by giving them an organ grown in a different species - rats. This is the first time an inter-species organ transplant has successfully treated a medical condition. The breakthrough is seen as proof of principle that'spare-part surgery' could one day be used to overcome disease in humans. Scientists have reversed diabetes in mice (stock image pictured) by giving them an organ grown in a different species - rats. Hiromitsu Nakauchi, a genetics professor at Stanford injected rat embryos with mouse stem cells.