I wore the world's first HDR10 smart glasses TCL's new E Ink tablet beats the Remarkable and Kindle Anker's new charger is one of the most unique I've ever seen I wore the world's first HDR10 smart glasses TCL's new E Ink tablet beats the Remarkable and Kindle Anker's new charger is one of the most unique I've ever seen I tried the new ChatGPT Desktop App for Linux - but I'll stick to my browser for now This preview release of ChatGPT Desktop for Linux supports Ubuntu, Debian, and Fedora is here. The application is proprietary, not open source. I'll keep using ChatGPT in the browser. OpenAI has released a preview of its ChatGPT desktop application for Linux . With this, OpenAI now has a native client on all major desktop operating systems and is placing its coding agent, Codex, alongside ChatGPT and its Work environment.

CogTwin is a hybrid cognitive architecture framework designed to bring autonomous reasoning and real-time adaptation to digital twin systems. Presented at IJCAI 2025, this work aims to advance the state of digital twin technology by addressing key gaps in autonomy, cognition, and real-time decision-making. Digital twin technology has transformed how complex systems are managed, from smart cities to industrial processes. However, most current digital twins remain fundamentally reactive: they rely on pre-programmed rules and static data-driven models, and therefore struggle when confronted with unforeseen events or evolving conditions. Real-time learning, reasoning, and adaptation - hallmarks of human cognition - are largely absent.

At the end of last year, Adobe leveraged OpenAI's Apps SDK to bring Photoshop, Acrobat and Adobe Express to ChatGPT. Now, the company is bringing nearly its entire suite of creative apps to ChatGPT with the introduction of the Adobe plugin. All told, once you've added the extension to your account, you'll have access to more than 70 of Adobe's tools, including Photoshop, Premiere, Acrobat, Lightroom, Illustrator and InDesign. To add the extension, open ChatGPT's settings menu and navigate to the plugins section, then select the Adobe one. You can then invoke it by typing @Adobe into ChatGPT's prompt bar, followed by your request.

Apple's upgraded AI assistant is finally here. Apple is finally attempting to deliver the next-gen, AI-infused Siri experience. The iOS 27 beta is centered around an elevated Siri, transformed from a basic voice commander to something closer to the intelligent, personal helper we were promised years ago. In iOS 27, Apple is prioritizing day-to-day utility over flashy gimmicks. The new Siri is smarter and faster, and it even has its own app to call home, while the company has focused on software efficiency gains -- especially on older devices.

The advent of single-cell Assay for Transposase-Accessible Chromatin using sequencing (scATAC-seq) offers an innovative perspective for deciphering regulatory mechanisms by assembling a vast repository of single-cell chromatin accessibility data. While foundation models have achieved significant success in single-cell transcriptomics, there is currently no foundation model for scATAC-seq that supports zero-shot high-quality cell identification and comprehensive multi-omics analysis simultaneously. Key challenges lie in the high dimensionality and sparsity of scATAC-seq data, as well as the lack of a standardized schema for representing open chromatin regions (OCRs). Here, we present ChromFound, a foundation model tailored for scATAC-seq. ChromFound utilizes a hybrid architecture and genome-aware tokenization to effectively capture genome-wide long contexts and regulatory signals from dynamic chromatin landscapes. Pretrained on 1.97 million cells from 30 tissues and 6 disease conditions, ChromFound demonstrates broad applicability across 6 diverse tasks. Notably, it achieves robust zero-shot performance in generating universal cell representations and exhibits excellent transferability in cell type annotation and cross-omics prediction. By uncovering enhancer-gene links undetected by existing computational methods, ChromFound offers a promising framework for understanding disease risk variants in the noncoding genome.

Synthetic tabular data enables microdata sharing in regulated domains, yet deploying continuous-time generative models requires balancing analytical utility, disclosure risk, and computational cost. Latent-space flow models are flexible, but theoretical equivalences across learning targets, probability paths, and sampling dynamics can translate into different behaviour under finite-step integration and explicit compute budgets. We present an empirical study of tabular latent flow models across seven datasets, evaluating velocity, score, noise, and posterior matching objectives under optimal transport (OT) and variance-preserving (VP) paths, ODE and SDE sampling, and varying integration budgets. Our contributions are threefold: (1) we show that the learning target largely determines the utility-risk operating regime, with velocity and posterior matching tending to yield higher utility, while score and noise matching tend to achieve lower disclosure risk; (2) we demonstrate that configuration and sampling choices shift performance, with midpoint often improving distributional fidelity and OT paths often tolerating earlier stopping than VP, enabling compute savings under fixed budgets or risk thresholds; and (3) we distil these findings into actionable defaults and practical configuration guidance to support pre-release model selection under disclosure risk and resource constraints. The code implementation and supplementary materials can be accessed in https://github.com/rulnasution/tabular-latent-flow/.

However, their widespread adoption is hindered by critical limitations, such as low information transfer rates and extensive user-specific calibration. To overcome these challenges, recent research has explored the integration of Large Language Models (LLMs), extending the focus from simple command decoding to understanding complex cognitive states. Despite these advancements, deploying agentic AI faces technical hurdles and ethical concerns. Due to the lack of comprehensive discussion on this emerging direction, this position paper argues that the field is poised for a paradigm extension from BCI to Brain-Agent Collaboration (BAC). We emphasize reframing agents as active and collaborative partners for intelligent assistance rather than passive brain signal data processors, demanding a focus on ethical data handling, model reliability, and a robust human-agent collaboration framework to ensure these systems are safe, trustworthy, and effective.

Understanding cellular responses to chemical interventions is critical to the discovery of effective therapeutics. Because individual biological techniques often measure only one axis of cellular response at a time, high-quality multimodal datasets are needed to unlock a holistic understanding of how cells respond to treatments and to advance computational methods that integrate modalities. However, many techniques destroy cells and thus preclude paired measurements, and attempts to match disparate unimodal datasets are often confounded by data being generated in incompatible experimental settings. Here we introduce scGeneScope, a multimodal single-cell RNA sequencing (scRNA-seq) and Cell Painting microscopy image dataset conditionally paired by chemical treatment, designed to facilitate the development and benchmarking of unimodal, multimodal, and multiple profile machine learning methods for cellular profiling.

How precisely does circuit wiring specify function? This fundamental question is particularly relevant for modern neuroscience, as large-scale electron microscopy now enables the reconstruction of neural circuits at single-synapse resolution across many organisms. To interpret circuit function from such datasets, we must understand the extent to which the measured structure constrains dynamics. We investigate this question in the Drosophila head direction (HD) circuit, which maintains an internal heading estimate through attractor dynamics that integrate self-motion velocity cues. This circuit serves as a sensitive assay for functional specification: continuous attractor networks are theoretically known to require finely tuned wiring symmetries, whereas connectomes omit key cellular parameters such as synaptic gains, neuronal thresholds, and time constants, and reveal that biological wiring can be heterogeneous. We introduce a method that combines selfsupervised and unsupervised learning objectives to estimate unknown parameters at the level of cell types, rather than individual neurons and synapses. Starting from the raw connectivity matrix, our approach recovers a network that exhibits continuous attractor dynamics and accurately integrates a range of velocity inputs, despite minimal parameter tuning on a connectome that notably departs from the symmetric regularity of an idealized ring attractor. We characterize how deviations from the original connectome shape the space of viable solutions. We also perform in-silico ablation experiments to probe the distinct functional roles of specific cell types in the circuit, demonstrating how connectome-derived structure, when augmented with minimal, biologically grounded tuning, can replicate known physiology and elucidate circuit function.

Designing optimal Bayes filters for nonlinear non-Gaussian systems is a challenging task. The main difficulties are: 1) representing complex beliefs, 2) handling non-Gaussian noise, and 3) marginalizing past states. To address these challenges, we focus on polynomial systems and propose the Max Entropy Moment Kalman Filter (MEM-KF). To address 1), we represent arbitrary beliefs by a MomentConstrained Max-Entropy Distribution (MED). The MED can asymptotically approximate almost any distribution given an increasing number of moment constraints. To address 2), we model the noise in the process and observation model as MED. To address 3), we propagate the moments through the process model and recover the distribution as MED, thus avoiding symbolic integration, which is generally intractable. All the steps in MEM-KF, including the extraction of a point estimate, can be solved via convex optimization.