A potential Retinal Vein Occlusion (RVO) treatment involves Retinal Vein Cannulation (RVC), which requires the surgeon to insert a microneedle into the affected retinal vein and administer a clot-dissolving drug. This procedure presents significant challenges due to human physiological limitations, such as hand tremors, prolonged tool-holding periods, and constraints in depth perception using a microscope. This study proposes a robot-assisted workflow for RVC to overcome these limitations. The test robot is operated through a keyboard. An intraoperative Optical Coherence Tomography (iOCT) system is used to verify successful venous puncture before infusion. The workflow is validated using 12 ex vivo porcine eyes. These early results demonstrate a successful rate of 10 out of 12 cannulations (83.33%), affirming the feasibility of the proposed workflow.

Implicit Neural Representations (INRs) are a learning-based approach to accelerate Magnetic Resonance Imaging (MRI) acquisitions, particularly in scan-specific settings when only data from the under-sampled scan itself are available. Previous work demonstrates that INRs improve rapid MRI through inherent regularization imposed by neural network architectures. Typically parameterized by fully-connected neural networks, INRs support continuous image representations by taking a physical coordinate location as input and outputting the intensity at that coordinate. Previous work has applied unlearned regularization priors during INR training and have been limited to 2D or low-resolution 3D acquisitions. Meanwhile, diffusion based generative models have received recent attention as they learn powerful image priors decoupled from the measurement model. This work proposes INFusion, a technique that regularizes the optimization of INRs from under-sampled MR measurements with pre-trained diffusion models for improved image reconstruction. In addition, we propose a hybrid 3D approach with our diffusion regularization that enables INR application on large-scale 3D MR datasets. 2D experiments demonstrate improved INR training with our proposed diffusion regularization, and 3D experiments demonstrate feasibility of INR training with diffusion regularization on 3D matrix sizes of 256 by 256 by 80.

Text-to-image (T2I) customization aims to create images that embody specific visual concepts delineated in textual descriptions. However, existing works still face a main challenge, concept overfitting. To tackle this challenge, we first analyze overfitting, categorizing it into concept-agnostic overfitting, which undermines non-customized concept knowledge, and concept-specific overfitting, which is confined to customize on limited modalities, i.e, backgrounds, layouts, styles. To evaluate the overfitting degree, we further introduce two metrics, i.e, Latent Fisher divergence and Wasserstein metric to measure the distribution changes of non-customized and customized concept respectively. Drawing from the analysis, we propose Infusion, a T2I customization method that enables the learning of target concepts to avoid being constrained by limited training modalities, while preserving non-customized knowledge. Remarkably, Infusion achieves this feat with remarkable efficiency, requiring a mere 11KB of trained parameters. Extensive experiments also demonstrate that our approach outperforms state-of-the-art methods in both single and multi-concept customized generation.

Long documents often exhibit structure with hierarchically organized elements of different functions, such as section headers and paragraphs. Despite the omnipresence of document structure, its role in natural language processing (NLP) remains opaque. Do long-document Transformer models acquire an internal representation of document structure during pre-training? How can structural information be communicated to a model after pre-training, and how does it influence downstream performance? To answer these questions, we develop a novel suite of probing tasks to assess structure-awareness of long-document Transformers, propose general-purpose structure infusion methods, and evaluate the effects of structure infusion on QASPER and Evidence Inference, two challenging long-document NLP tasks. Results on LED and LongT5 suggest that they acquire implicit understanding of document structure during pre-training, which can be further enhanced by structure infusion, leading to improved end-task performance. To foster research on the role of document structure in NLP modeling, we make our data and code publicly available.

Large language models (LLMs) have demonstrated remarkable performance in a wide range of natural language tasks. However, as these models continue to grow in size, they face significant challenges in terms of computational costs. Additionally, LLMs often lack efficient domain-specific understanding, which is particularly crucial in specialized fields such as aviation and healthcare. To boost the domain-specific understanding, we propose, KITLM, a novel knowledge base integration approach into language model through relevant information infusion. By integrating pertinent knowledge, not only the performance of the language model is greatly enhanced, but the model size requirement is also significantly reduced while achieving comparable performance. Our proposed knowledge-infused model surpasses the performance of both GPT-3.5-turbo and the state-of-the-art knowledge infusion method, SKILL, achieving over 1.5 times improvement in exact match scores on the MetaQA. KITLM showed a similar performance boost in the aviation domain with AeroQA. The drastic performance improvement of KITLM over the existing methods can be attributed to the infusion of relevant knowledge while mitigating noise. In addition, we release two curated datasets to accelerate knowledge infusion research in specialized fields: a) AeroQA, a new benchmark dataset designed for multi-hop question-answering within the aviation domain, and b) Aviation Corpus, a dataset constructed from unstructured text extracted from the National Transportation Safety Board reports. Our research contributes to advancing the field of domain-specific language understanding and showcases the potential of knowledge infusion techniques in improving the performance of language models on question-answering.

Accurately predicting anesthetic effects is essential for target-controlled infusion systems. The traditional (PK-PD) models for Bispectral index (BIS) prediction require manual selection of model parameters, which can be challenging in clinical settings. Recently proposed deep learning methods can only capture general trends and may not predict abrupt changes in BIS. To address these issues, we propose a transformer-based method for predicting the depth of anesthesia (DOA) using drug infusions of propofol and remifentanil. Our method employs long short-term memory (LSTM) and gate residual network (GRN) networks to improve the efficiency of feature fusion and applies an attention mechanism to discover the interactions between the drugs. We also use label distribution smoothing and reweighting losses to address data imbalance. Experimental results show that our proposed method outperforms traditional PK-PD models and previous deep learning methods, effectively predicting anesthetic depth under sudden and deep anesthesia conditions.

Human-annotated labels and explanations are critical for training explainable NLP models. However, unlike human-annotated labels whose quality is easier to calibrate (e.g., with a majority vote), human-crafted free-form explanations can be quite subjective. Before blindly using them as ground truth to train ML models, a vital question needs to be asked: How do we evaluate a human-annotated explanation's quality? In this paper, we build on the view that the quality of a human-annotated explanation can be measured based on its helpfulness (or impairment) to the ML models' performance for the desired NLP tasks for which the annotations were collected. In comparison to the commonly used Simulatability score, we define a new metric that can take into consideration the helpfulness of an explanation for model performance at both fine-tuning and inference. With the help of a unified dataset format, we evaluated the proposed metric on five datasets (e.g., e-SNLI) against two model architectures (T5 and BART), and the results show that our proposed metric can objectively evaluate the quality of human-annotated explanations, while Simulatability falls short.

The integration of knowledge graphs with deep learning is thriving in improving the performance of various natural language processing (NLP) tasks. In this paper, we focus on knowledge-infused link prediction and question answering using language models, T5, and BLOOM across three domains: Aviation, Movie, and Web. In this context, we infuse knowledge in large and small language models and study their performance, and find the performance to be similar. For the link prediction task on the Aviation Knowledge Graph, we obtain a 0.2 hits@1 score using T5-small, T5-base, T5-large, and BLOOM. Using template-based scripts, we create a set of 1 million synthetic factoid QA pairs in the aviation domain from National Transportation Safety Board (NTSB) reports. On our curated QA pairs, the three models of T5 achieve a 0.7 hits@1 score. We validate out findings with the paired student t-test and Cohen's kappa scores. For link prediction on Aviation Knowledge Graph using T5-small and T5-large, we obtain a Cohen's kappa score of 0.76, showing substantial agreement between the models. Thus, we infer that small language models perform similar to large language models with the infusion of knowledge.

Sisense defines infusion as the practice of incorporating data and insights into end-user business applications. "Infusion is all about putting decision-supporting insights into a product in a way that feels native. And it's far more interesting," Scott Castle SVP of Product at Sisense says. Typically, a BI tool works by pulling data together to help end users draw their own conclusions. They aggregate data, slice and dice, figure it out, come to the insight and then, take action. Whereas, infusion speaks towards broadening perspective on what embedded analytics means to include more than just a chart to figure out.

Sisense defines infusion as the practice of incorporating data and insights into end-user business applications. "Infusion is all about putting decision-supporting insights into a product in a way that feels native. And it's far more interesting," Scott Castle SVP of Product at Sisense says. Typically, a BI tool works by pulling data together to help end users draw their own conclusions. They aggregate data, slice and dice, figure it out, come to the insight and then, take action.