We present a Bayesian dynamic borrowing (BDB) approach to enhance the quantitative identification of adverse events (AEs) in spontaneous reporting systems (SRSs). The method embeds a robust meta-analytic predictive (MAP) prior with a Bayesian hierarchical model and incorporates semantic similarity measures (SSMs) to enable weighted information sharing from clinically similar MedDRA Preferred Terms (PTs) to the target PT. This continuous similarity-based borrowing overcomes limitations of rigid hierarchical grouping in current disproportionality analysis (DPA). Using data from the FDA Adverse Event Reporting System (FAERS) between 2015 and 2019, we evaluate our approach -- termed IC SSM -- against traditional Information Component (IC) analysis and IC with borrowing at the MedDRA high-level group term level (IC HLGT). A reference set (PVLens), derived from FDA product label update, enabled prospective evaluation of method performance in identifying AEs prior to official labeling. The IC SSM approach demonstrated higher sensitivity (1332/2337=0.570, Youden's J=0.246) than traditional IC (Se=0.501, J=0.250) and IC HLGT (Se=0.556, J=0.225), consistently identifying more true positives and doing so on average 5 months sooner than traditional IC. Despite a marginally lower aggregate F1-score and Youden's index, IC SSM showed higher performance in early post-marketing periods or when the detection threshold was raised, providing more stable and relevant alerts than IC HLGT and traditional IC. These findings support the use of SSM-informed Bayesian borrowing as a scalable and context-aware enhancement to traditional DPA methods, with potential for validation across other datasets and exploration of additional similarity metrics and Bayesian strategies using case-level data.

Speech conveys different yet mixed information ranging from linguistic to speaker-specific components, and each of them should be exclusively used in a specific task. However, it is extremely difficult to extract a specific information component given the fact that nearly all existing acoustic representations carry all types of speech information. Thus, the use of the same representation in both speech and speaker recognition hinders a system from producing better performance due to interference of irrelevant information. In this paper, we present a deep neural architecture to extract speaker-specific information from MFCCs. As a result, a multi-objective loss function is proposed for learning speaker-specific characteristics and regularization via normalizing interference of non-speaker related information and avoiding information loss. With LDC benchmark corpora and a Chinese speech corpus, we demonstrate that a resultant speaker-specific representation is insensitive to text/languages spoken and environmental mismatches and hence outperforms MFCCs and other state-of-the-art techniques in speaker recognition. We discuss relevant issues and relate our approach to previous work.

Speech conveys different yet mixed information ranging from linguistic to speaker-specific components, and each of them should be exclusively used in a specific task. However, it is extremely difficult to extract a specific information component given the fact that nearly all existing acoustic representations carry all types of speech information. Thus, the use of the same representation in both speech and speaker recognition hinders a system from producing better performance due to interference of irrelevant information. In this paper, we present a deep neural architecture to extract speaker-specific information from MFCCs. As a result, a multi-objective loss function is proposed for learning speaker-specific characteristics and regularization via normalizing interference of non-speaker related information and avoiding information loss. With LDC benchmark corpora and a Chinese speech corpus, we demonstrate that a resultant speaker-specific representation is insensitive to text/languages spoken and environmental mismatches and hence outperforms MFCCs and other state-of-the-art techniques in speaker recognition. We discuss relevant issues and relate our approach to previous work.

High frequency foreign exchange data can be decomposed into three components: the inventory effect component, the surprise infonnation (news) component and the regular infonnation component. The presence of the inventory effect and news can make analysis of trends due to the diffusion of infonnation (regular information component) difficult. We propose a neural-net-based, independent component analysis to separate high frequency foreign exchange data into these three components. Our empirical results show that our proposed multi-effect decomposition can reveal the intrinsic price behavior.

High frequency foreign exchange data can be decomposed into three components: the inventory effect component, the surprise infonnation (news) component and the regular infonnation component. The presence of the inventory effect and news can make analysis of trends due to the diffusion of infonnation (regular information component) difficult. We propose a neural-net-based, independent component analysis to separate high frequency foreign exchange data into these three components. Our empirical results show that our proposed multi-effect decomposition can reveal the intrinsic price behavior.

High frequency foreign exchange data can be decomposed into three components: the inventory effect component, the surprise infonnation (news) component and the regular infonnation component. The presence of the inventory effect and news can make analysis of trends due to the diffusion of infonnation (regular information component) difficult. We propose a neural-net-based, independent component analysis to separate highfrequency foreign exchange data into these three components. Our empirical results show that our proposed multi-effect decomposition can reveal the intrinsic price behavior.