Breakthroughs, discoveries, and DIY tips sent six days a week. Whether it's the ocean's deepest hydrothermal vents or tall mountain peaks, bacteria is likely surviving and thriving. Ice caves can host a wide variety of microorganisms and offer biologists a bevy of genetic diversity that still has to be studied. And it could help save lives. A team of scientists in Romania tested antibiotic resistance profiles with a bacterial strain that was hidden in a 5,000-year-old layer of ice inside an underground ice cave.

Parents in north London have been told their children could be excluded from school if they are not fully vaccinated against measles amid an outbreak of the highly-contagious disease. Unvaccinated pupils identified as close contacts of people with measles could be excluded for 21 days in accordance with national guidelines, Enfield Council said in a letter to all parents in the borough in late January. At least 34 children have contracted measles in Enfield so far this year, the UK Health Security Agency (UKHSA) has said, and a number sent to hospital. A local health chief meanwhile told the BBC: We are worried because actually, this is a significantly increased number than what we're used to. Asking unvaccinated, close contacts of measles cases to stay off school is fairly standard practice when there are local outbreaks.

César de la Fuente is on a mission to combat antimicrobial resistance by looking at nature's own solutions. César de la Fuente is an associate professor at the University of Pennsylvania, where he leads the Machine Biology Group. When he was just a teenager trying to decide what to do with his life, César de la Fuente compiled a list of the world's biggest problems. He ranked them inversely by how much money governments were spending to solve them. Antimicrobial resistance topped the list. Twenty years on, the problem has not gone away.

Seven million people's cancer could be prevented each year, according to the first global analysis. A report by World Health Organization (WHO) scientists estimates 37% of cancers are caused by infections, lifestyle choices and environmental pollutants that could be avoided. This includes cervical cancers caused by human papilloma virus (HPV) infections which vaccination can help prevent, as well as a host of tumours caused by tobacco smoke from cigarettes. The researchers said their report showed there is a powerful opportunity to transform the lives of millions of people. Some cancers are inevitable - either because of damage we unavoidably build up in our DNA as we age or because we inherit genes that put us at greater risk of the disease.

Innovative research into the gene-editing tool targets influenza's ability to replicate--stopping it in its tracks. As he addressed an audience of virologists from China, Australia, and Singapore at October's Pandemic Research Alliance Symposium, Wei Zhao introduced an eye-catching idea. The gene-editing technology Crispr is best known for delivering groundbreaking new therapies for rare diseases, tweaking or knocking out rogue genes in conditions ranging from sickle cell disease to hemophilia . But Zhao and his colleagues at Melbourne's Peter Doherty Institute for Infection and Immunity have envisioned a new application. They believe Crispr could be tailored to create a next-generation treatment for influenza, whether that's the seasonal strains which plague both the northern and southern hemispheres on an annual basis, or the worrisome new variants in birds and other wildlife that might trigger the next pandemic.

A new strain of mpox, previously called monkeypox, has been detected in a person in England, say UK health officials. The virus is a mix of two major types of the mpox virus, and was found in someone who recently returned from travelling in Asia. Officials say they are still assessing the significance of the new strain. The UK Health Security Agency (UKHSA) says it is normal for viruses to evolve. Getting vaccinated remains the best way to protect against severe disease - although an mpox infection is mild for many.

Why our bodies shake when it's cold. Involuntary muscle contractions keep us warm and even fight infections. "Shivering is a way for our bodies to generate heat when we are cold," says Dr. Natasha Bhuyan, a family physician based in Phoenix, Arizona. Breakthroughs, discoveries, and DIY tips sent every weekday. You're walking down a Chicago street on a blustery winter day, when a particularly strong wind almost whips you off of your feet.

Machine learning for early prediction in medicine has recently shown breakthrough performance, however, the focus on improving prediction accuracy has led to a neglect of faithful explanations that are required to gain the trust of medical practitioners. The goal of this paper is to teach LLMs to follow medical consensus guidelines step-by-step in their reasoning and prediction process. Since consensus guidelines are ubiquitous in medicine, instantiations of verbalized medical inference rules to electronic health records provide data for fine-tuning LLMs to learn consensus rules and possible exceptions thereof for many medical areas. Consensus rules also enable an automatic evaluation of the model's inference process regarding its derivation correctness (evaluating correct and faithful deduction of a conclusion from given premises) and value correctness (comparing predicted values against real-world measurements). We exemplify our work using the complex Sepsis-3 consensus definition. Our experiments show that small fine-tuned models outperform one-shot learning of considerably larger LLMs that are prompted with the explicit definition and models that are trained on medical texts including consensus definitions. Since fine-tuning on verbalized rule instantiations of a specific medical area yields nearly perfect derivation correctness for rules (and exceptions) on unseen patient data in that area, the bottleneck for early prediction is not out-of-distribution generalization, but the orthogonal problem of generalization into the future by forecasting sparsely and irregularly sampled clinical variables. We show that the latter results can be improved by integrating the output representations of a time series forecasting model with the LLM in a multimodal setup.

Loss of lung function in cystic fibrosis (CF) occurs progressively, punctuated by acute pulmonary exacerbations (PEx) in which abrupt declines in lung function are not fully recovered. A key component of CF management over the past half century has been the treatment of PEx to slow lung function decline. This has been credited with improvements in survival for people with CF (PwCF), but there is no consensus on the optimal approach to PEx management. BEAT-CF (Bayesian evidence-adaptive treatment of CF) was established to build an evidence-informed knowledge base for CF management. The BEAT-CF causal model is a directed acyclic graph (DAG) and Bayesian network (BN) for PEx that aims to inform the design and analysis of clinical trials comparing the effectiveness of alternative approaches to PEx management. The causal model describes relationships between background risk factors, treatments, and pathogen colonisation of the airways that affect the outcome of an individual PEx episode. The key factors, outcomes, and causal relationships were elicited from CF clinical experts and together represent current expert understanding of the pathophysiology of a PEx episode, guiding the design of data collection and studies and enabling causal inference. Here, we present the DAG that documents this understanding, along with the processes used in its development, providing transparency around our trial design and study processes, as well as a reusable framework for others.

As COVID-19 transitions into an endemic disease that remains constantly present in the population at a stable level, monitoring its prevalence without invasive measures becomes increasingly important. In this paper, we present a deep neural network estimator for the COVID-19 daily case count based on wastewater surveillance data and other confounding factors. This work builds upon the study by Jiang, Kolozsvary, and Li (2024), which connects the COVID-19 case counts with testing data collected early in the pandemic. Using the COVID-19 testing data and the wastewater surveillance data during the period when both data were highly reliable, one can train an artificial neural network that learns the nonlinear relation between the COVID-19 daily case count and the wastewater viral RNA concentration. From a machine learning perspective, the main challenge lies in addressing temporal feature reliability, as the training data has different reliability over different time periods.