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'I was given a choice - keep my legs or keep my life' - the sepsis patient who lived

BBC News

'I was given a choice - keep my legs or keep my life' - the sepsis patient who lived Farmer Marshall Wylie thought nothing of it when he cut his arm, sorting wood in August 2023. And he thought even less of it when he felt ill over the next 48 hours. But the following week, he said he clinically died due to sepsis, and eventually his legs had to be amputated. Farmers are at particular risk of developing sepsis due to incidents on the farm, but can also be reluctant to seek healthcare. Warning: This article contains some graphic images of hands and feet with sepsis.


All Your Hantavirus Questions, Answered by an Infectious Disease Expert

WIRED

Here's what you need to know, from why the cruise ship outbreak won't spark the next pandemic to how hantavirus spreads. Now that more than 100 passengers aboard a hantavirus -stricken luxury cruise ship have been evacuated, with 18 Americans in biocontainment units in Nebraska and Georgia, health officials around the world are working to monitor more than two dozen individuals who left the cruise and anyone with whom they might have come in close contact. So far, all of the 11 reported hantavirus cases are among passengers or crew on the ship, the World Health Organization's director-general Tedros Adhanom Ghebreyesus said at a press conference in Madrid on Tuesday. That includes three deaths resulting from the virus. Typically, hantaviruses are spread when contaminated rodent droppings and urine are stirred up in the air and breathed in.


Hantavirus Conspiracy Theories Are Already Spreading Online

WIRED

From claims of an Israeli false flag to efforts to sell ivermectin, influencers and grifters are using lessons learned from Covid-19 to push their baseless conspiracy theories. Conspiracy theorists, wellness influencers, and grifters have already started promoting wild claims about the hantavirus outbreak that began aboard the MV, a cruise ship on the Atlantic. Some conspiracy theorists compared the outbreak to the Covid-19 pandemic, claiming it was another effort to control the global population, while others pushed a false narrative that the Covid-19 vaccine caused hantavirus. Many others promoted ivermectin as a treatment, using the incident as a way to sell emergency medical kits featuring the antiparasitic drug typically used as a horse dewormer. In more recent days, many of these same people spreading conspiracy theories have promoted the baseless and antisemitic claims that the entire incident is a false flag orchestrated by Israel.


Some Women Are Obsessively Testing Their Vaginas to Optimize Them

WIRED

Biohacker Bryan Johnson recently bragged about his girlfriend's "top 1%" vagina as the at-home vaginal microbiome test industry is thriving. Farrah was fed up with her vagina . For the past two years, the 29-year-old dancer from Ohio had been dealing with severe pelvic pain and vaginal odor. "It was like 8/10, horrible core pain," she says. When she visited doctors, she told them what she thought the culprit was: an allergic reaction to soy oil in a vat of water she'd swam in during a pirate-themed dinner theater performance. But they didn't believe her.


A New Hantavirus Vaccine Is in the Works

WIRED

Since 2023, Moderna and Korea University have been developing a new mRNA vaccine for hantavirus. The work has been promising so far, but a finished product isn't likely coming any time soon. US-based pharmaceutical company Moderna confirmed that it has been working on the development of hantavirus vaccines in collaboration with the Vaccine Innovation Center of Korea University College of Medicine (VIC-K). This comes after an outbreak of hantavirus occurred on a Dutch cruise ship that sailed from Argentina and disembarked its passengers and crew in the Canary Islands on May 10. At least three people aboard the MV died, and several cases were reported as serious.


Could Contact-Tracing Apps Help With the Hantavirus? Not Really

WIRED

Could Contact-Tracing Apps Help With the Hantavirus? Contact-tracing apps were widely deployed during the Covid pandemic. After three people died on a cruise ship struck by a hantavirus, authorities are actively tracking down 29 people who had left the ship. They're trying to trace the spread of the virus. It's a long, arduous, global process to find and notify people who might be at risk of infection.


Venom and Hot Peppers Offer a Key to Killing Resistant Bacteria

WIRED

Researchers have developed three new antibiotics from scorpion venom and habanero peppers to combat tuberculosis and other drug-resistant pathogens. Researchers from the National Autonomous University of Mexico (UNAM) have identified new ways to combat tuberculosis and reduce bacterial resistance, developing three new antibiotics derived from scorpion venom and habanero peppers. A team led by Lourival Domingos Possani Postay, from the Institute of Biotechnology's Morelos campus, created two drugs that demonstrated efficacy against the bacterium, responsible for tuberculosis, as well as against, a microorganism that in hospital environments can cause various clinical complications, from skin infections to potentially fatal diseases such as pneumonia, meningitis, septicemia, and endocarditis. The antibiotics were derived from the venom of the scorpion, native to the state of Veracruz. The team was able to isolate two colorless molecules called benzoquinones--heterocyclic compounds that do not contain amino acids--from the arachnid's toxin.


Why the Hantavirus Cruise Ship Outbreak Isn't Likely to Become a Global Crisis

WIRED

Here's What You Need to Know About the Hantavirus While the outbreak aboard a cruise ship in the Atlantic is concerning, the virus isn't easily transmitted through casual contact. Cruises are so closely associated with illness that the highly contagious norovirus is commonly called the "cruise ship virus." But a ship headed for Spain's Canary Islands has attracted global attention due to a rare outbreak of hantavirus that's left three dead. While alarming, health officials and infectious disease experts say the risk to the general public right now is low because hantavirus is less contagious than other respiratory diseases like the coronavirus responsible for the Covid-19 pandemic . "This is not Covid, this is not influenza. It spreads very, very differently," Maria Van Kerkhove, director of epidemic and pandemic preparedness and prevention at the World Health Organization, said at a press conference on Thursday.


Computing and maximizing influence in linear threshold and triggering models

Neural Information Processing Systems

We establish upper and lower bounds for the influence of a set of nodes in certain types of contagion models. We derive two sets of bounds, the first designed for linear threshold models, and the second more broadly applicable to a general class of triggering models, which subsumes the popular independent cascade models, as well. We quantify the gap between our upper and lower bounds in the case of the linear threshold model and illustrate the gains of our upper bounds for independent cascade models in relation to existing results. Importantly, our lower bounds are monotonic and submodular, implying that a greedy algorithm for influence maximization is guaranteed to produce a maximizer within a 1 1e -factor of the truth. Although the problem of exact influence computation is NP-hard in general, our bounds may be evaluated efficiently. This leads to an attractive, highly scalable algorithm for influence maximization with rigorous theoretical guarantees.


What are the symptoms of meningitis and is there a vaccine?

BBC News

What are the symptoms of meningitis and is there a vaccine? Two people have died following an outbreak of meningitis in Kent. The death of a year 13 pupil at Queen Elizabeth's Grammar School in Faversham was confirmed by the local MP on Monday. The second person who died was a student at the University of Kent. The UK Health Security Agency (UKHSA) said it was notified of 13 cases with signs and symptoms of meningitis and septicaemia from Friday to Sunday in the Canterbury area.