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Cognitive bias in LLM reasoning compromises interpretation of clinical oncology notes

Kenaston, Matthew W., Ayub, Umair, Parmar, Mihir, Anjum, Muhammad Umair, Naqvi, Syed Arsalan Ahmed, Kumar, Priya, Rawal, Samarth, Chaudhuri, Aadel A., Zakharia, Yousef, Heath, Elizabeth I., Bekaii-Saab, Tanios S., Tao, Cui, Van Allen, Eliezer M., Zhou, Ben, Choi, YooJung, Baral, Chitta, Riaz, Irbaz Bin

arXiv.org Artificial Intelligence

Despite high performance on clinical benchmarks, large language models may reach correct conclusions through faulty reasoning, a failure mode with safety implications for oncology decision support that is not captured by accuracy-based evaluation. In this two-cohort retrospective study, we developed a hierarchical taxonomy of reasoning errors from GPT-4 chain-of-thought responses to real oncology notes and tested its clinical relevance. Using breast and pancreatic cancer notes from the CORAL dataset, we annotated 600 reasoning traces to define a three-tier taxonomy mapping computational failures to cognitive bias frameworks. We validated the taxonomy on 822 responses from prostate cancer consult notes spanning localized through metastatic disease, simulating extraction, analysis, and clinical recommendation tasks. Reasoning errors occurred in 23 percent of interpretations and dominated overall errors, with confirmation bias and anchoring bias most common. Reasoning failures were associated with guideline-discordant and potentially harmful recommendations, particularly in advanced disease management. Automated evaluators using state-of-the-art language models detected error presence but could not reliably classify subtypes. These findings show that large language models may provide fluent but clinically unsafe recommendations when reasoning is flawed. The taxonomy provides a generalizable framework for evaluating and improving reasoning fidelity before clinical deployment.



Fairness-Enhancing Ensemble Classification in Water Distribution Networks

Strotherm, Janine, Hammer, Barbara

arXiv.org Artificial Intelligence

As relevant examples such as the future criminal detection software [1] show, fairness of AI-based and social domain affecting decision support tools constitutes an important area of research. In this contribution, we investigate the applications of AI to socioeconomically relevant infrastructures such as those of water distribution networks (WDNs), where fairness issues have yet to gain a foothold. To establish the notion of fairness in this domain, we propose an appropriate definition of protected groups and group fairness in WDNs as an extension of existing definitions. We demonstrate that typical methods for the detection of leakages in WDNs are unfair in this sense. Further, we thus propose a remedy to increase the fairness which can be applied even to non-differentiable ensemble classification methods as used in this context.


Optical Flow Matters: an Empirical Comparative Study on Fusing Monocular Extracted Modalities for Better Steering

Makiyeh, Fouad, Bastourous, Mark, Bairouk, Anass, Xiao, Wei, Maras, Mirjana, Wangb, Tsun-Hsuan, Blanchon, Marc, Hasani, Ramin, Chareyre, Patrick, Rus, Daniela

arXiv.org Artificial Intelligence

Autonomous vehicle navigation is a key challenge in artificial intelligence, requiring robust and accurate decision-making processes. This research introduces a new end-to-end method that exploits multimodal information from a single monocular camera to improve the steering predictions for self-driving cars. Unlike conventional models that require several sensors which can be costly and complex or rely exclusively on RGB images that may not be robust enough under different conditions, our model significantly improves vehicle steering prediction performance from a single visual sensor. By focusing on the fusion of RGB imagery with depth completion information or optical flow data, we propose a comprehensive framework that integrates these modalities through both early and hybrid fusion techniques. We use three distinct neural network models to implement our approach: Convolution Neural Network - Neutral Circuit Policy (CNN-NCP) , Variational Auto Encoder - Long Short-Term Memory (VAE-LSTM) , and Neural Circuit Policy architecture VAE-NCP. By incorporating optical flow into the decision-making process, our method significantly advances autonomous navigation. Empirical results from our comparative study using Boston driving data show that our model, which integrates image and motion information, is robust and reliable. It outperforms state-of-the-art approaches that do not use optical flow, reducing the steering estimation error by 31%. This demonstrates the potential of optical flow data, combined with advanced neural network architectures (a CNN-based structure for fusing data and a Recurrence-based network for inferring a command from latent space), to enhance the performance of autonomous vehicles steering estimation.


Graph-based Unsupervised Disentangled Representation Learning via Multimodal Large Language Models

Xie, Baao, Chen, Qiuyu, Wang, Yunnan, Zhang, Zequn, Jin, Xin, Zeng, Wenjun

arXiv.org Artificial Intelligence

Disentangled representation learning (DRL) aims to identify and decompose underlying factors behind observations, thus facilitating data perception and generation. However, current DRL approaches often rely on the unrealistic assumption that semantic factors are statistically independent. In reality, these factors may exhibit correlations, which off-the-shelf solutions have yet to properly address. To tackle this challenge, we introduce a bidirectional weighted graph-based framework, to learn factorized attributes and their interrelations within complex data. Specifically, we propose a $\beta$-VAE based module to extract factors as the initial nodes of the graph, and leverage the multimodal large language model (MLLM) to discover and rank latent correlations, thereby updating the weighted edges. By integrating these complementary modules, our model successfully achieves fine-grained, practical and unsupervised disentanglement. Experiments demonstrate our method's superior performance in disentanglement and reconstruction. Furthermore, the model inherits enhanced interpretability and generalizability from MLLMs.


Explainability of machine learning approaches in forensic linguistics: a case study in geolinguistic authorship profiling

Roemling, Dana, Scherrer, Yves, Miletic, Aleksandra

arXiv.org Artificial Intelligence

Forensic authorship profiling uses linguistic markers to infer characteristics about an author of a text. This task is paralleled in dialect classification, where a prediction is made about the linguistic variety of a text based on the text itself. While there have been significant advances in recent years in variety classification, forensic linguistics rarely relies on these approaches due to their lack of transparency, among other reasons. In this paper we therefore explore the explainability of machine learning approaches considering the forensic context. We focus on variety classification as a means of geolinguistic profiling of unknown texts based on social media data from the German-speaking area. For this, we identify the lexical items that are the most impactful for the variety classification. We find that the extracted lexical features are indeed representative of their respective varieties and note that the trained models also rely on place names for classifications.


Supervisory Prompt Training

Billa, Jean Ghislain, Oh, Min, Du, Liang

arXiv.org Artificial Intelligence

The performance of Large Language Models (LLMs) relies heavily on the quality of prompts, which are often manually engineered and task-specific, making them costly and non-scalable. We propose a novel approach, Supervisory Prompt Training (SPT). SPT automates the generation of highly effective prompts using a dual LLM system. In this system, one LLM, the generator, performs a task while the other, the corrector, provides feedback and generates improved prompts. In contrast to earlier techniques, both the generator and corrector collaboratively and continuously improve their prompts over time. We also introduce the concept of \textit{impact scores} to measure the sentence-level effectiveness of the prompts. Our method was tested on four benchmarks, testing the level of hallucinations in LLMs. Notably, we were able to increase the accuracy of GPT-4 on GSM8K from 65.8\% to 94.1\% (28.3\% increase). SPT advances LLMs by refining prompts to enhance performance and reduce hallucinations, offering an efficient and scalable alternative to traditional model fine-tuning.


ViT-CX: Causal Explanation of Vision Transformers

Xie, Weiyan, Li, Xiao-Hui, Cao, Caleb Chen, Zhang, Nevin L.

arXiv.org Artificial Intelligence

Despite the popularity of Vision Transformers (ViTs) and eXplainable AI (XAI), only a few explanation methods have been designed specially for ViTs thus far. They mostly use attention weights of the [CLS] token on patch embeddings and often produce unsatisfactory saliency maps. This paper proposes a novel method for explaining ViTs called ViT-CX. It is based on patch embeddings, rather than attentions paid to them, and their causal impacts on the model output. Other characteristics of ViTs such as causal overdetermination are also considered in the design of ViT-CX. The empirical results show that ViT-CX produces more meaningful saliency maps and does a better job revealing all important evidence for the predictions than previous methods. The explanation generated by ViT-CX also shows significantly better faithfulness to the model. The codes and appendix are available at https://github.com/vaynexie/CausalX-ViT.


Quantifying the Benefit of Artificial Intelligence for Scientific Research

Gao, Jian, Wang, Dashun

arXiv.org Artificial Intelligence

The ongoing artificial intelligence (AI) revolution has the potential to change almost every line of work. As AI capabilities continue to improve in accuracy, robustness, and reach, AI may outperform and even replace human experts across many valuable tasks. Despite enormous efforts devoted to understanding AI's impact on labor and the economy and its recent success in accelerating scientific discovery and progress, we lack a systematic understanding of how advances in AI may benefit scientific research across disciplines and fields. Here we develop a measurement framework to estimate both the direct use of AI and the potential benefit of AI in scientific research by applying natural language processing techniques to 87.6 million publications and 7.1 million patents. We find that the use of AI in research appears widespread throughout the sciences, growing especially rapidly since 2015, and papers that use AI exhibit an impact premium, more likely to be highly cited both within and outside their disciplines. While almost every discipline contains some subfields that benefit substantially from AI, analyzing 4.6 million course syllabi across various educational disciplines, we find a systematic misalignment between the education of AI and its impact on research, suggesting the supply of AI talents in scientific disciplines is not commensurate with AI research demands. Lastly, examining who benefits from AI within the scientific workforce, we find that disciplines with a higher proportion of women or black scientists tend to be associated with less benefit, suggesting that AI's growing impact on research may further exacerbate existing inequalities in science. As the connection between AI and scientific research deepens, our findings may have an increasing value, with important implications for the equity and sustainability of the research enterprise.