Follow this author to personalize your feed and get instant alerts. Follow Go to your personalized feed WHY FOLLOW? Smart Alerts: Get notified about major news as it happens. It seems odd that your body's internal age may differ from your chronological one. But Tony Wyss-Coray, a Swiss professor of neurology and director of the Knight Initiative for Brain Resilience at Stanford University, has pioneered ways to measure a person's "biological age," which scientists say more accurately reflects how a body is aging than does chronological age.

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CAR-T cell therapy is already a potent treatment for certain cancers. Now, a small study is showing early promise for managing HIV. A Miracle cancer therapy that involves engineering a patient's own immune cells is being repurposed for HIV, and early results from two individuals hint at its promise for long-term control of the virus. As part of a clinical trial, scientists took people's own immune cells and reprogrammed them in a lab to recognize and attack HIV in the body. After a single infusion of the modified cells, two individuals with HIV now have undetectable levels of the virus--one for nearly two years and the other for almost a year.

At WIRED Health, immunologist Daniel Davis detailed the ways in which new technologies are enabling a better understanding of the human immune system. The immune system operates at a scale scientists are only just beginning to be able to see. That new view could change how diseases like cancer are tackled. Speaking at WIRED Health on April 16, Daniel Davis, an immunologist at Imperial College London, detailed how researchers are using advanced microscopes to uncover previously invisible dynamics in the human immune system, showing that there are multiple processes happening on a "nanoscale" that was previously out of reach. That new view is already reshaping how immunity is understood.

Scientists discover how a vitamin A byproduct may weaken immune responses against cancer, potentially explaining why some immunotherapies fail in patients.

A therapy that would once have been considered a feat of science fiction has reversed aggressive and incurable blood cancers in some patients, doctors report. The treatment involves precisely editing the DNA in white blood cells to transform them into a cancer-fighting living drug. The first girl to be treated, whose story we reported in 2022, is still free of the disease and now plans to become a cancer scientist. Now eight more children and two adults with T-cell acute lymphoblastic leukaemia have been treated, with almost two thirds (64%) of patients in remission. T-cells are supposed to be the body's guardians - seeking out and destroying threats - but in this form of leukaemia, they grow out of control.

Can AI Look at Your Retina and Diagnose Alzheimer's? The author of believes AI could bring big changes to the world of medicine. For decades now, it's been fairly well established that once you turn 40 you should start paying more attention to your body. That's when women are supposed to start getting mammograms and men are supposed to start paying a bit more attention to their prostates. Over the next decade, you'll start getting colonoscopies, and from then on out, it feels like a gradual march of doctor's appointments and tests until your body collapses sometime in your seventies or eighties.

As the promise of artificial intelligence (AI) captivates biomedicine, few people are riding the wave like Priscilla Chan--because few people have her resources. Trained as a pediatrician, Chan and her husband, Facebook creator Mark Zuckerberg, co-run a philanthropy that launched in 2015 with the wildly ambitious--some would say quixotic--goal of curing, preventing, or managing every disease by the end of the century. The couple pledged nearly their entire fortune-- 45 billion then and more than 200 billion today--to the Chan Zuckerberg Initiative (CZI), which would also support their education and progressive causes. Recently, however, the foundation has wound down support for almost everything but science. And this week, CZI announced it is increasing its research spending, doubling down on AI, and vowing to meet Chan and Zuckerberg's biomedical goal even earlier--although CZI won't set a specific target.

Experts reveal signs of immune aging, including frequent infections and slower wound healing, with lifestyle factors like diet and sleep playing crucial roles.

Health Diseases Donor organ's blood type altered for the first time Scientists removed the blood's antigens to make a kidney the universal type-O. Breakthroughs, discoveries, and DIY tips sent every weekday. In a world first, researchers at the University of British Columbia (UBC) in Canada successfully transplanted a human donor kidney that they artificially swapped from someone with type-A blood to the universal type-O. The breakthrough may pave the way for the creation of a universal donor blood supply, as well as the ability to pull off similar results with other vital organs. The riskiest and often most difficult part of an organ transplant procedure is the distinct possibility that a patients' body will reject the organ itself .