The study aims to investigate the similarities and differences in the brain damage caused by Hypoxia-Ischemia (HI), Hypoglycemia, and Epilepsy. Hypoglycemia poses a significant challenge in improving glycemic regulation for insulin-treated patients, while HI brain disease in neonates is associated with low oxygen levels. The study examines the possibility of using a combination of medical data and Electroencephalography (EEG) measurements to predict outcomes over a two-year period. The study employs a multilevel fusion of data features to enhance the accuracy of the predictions. Therefore this paper suggests a hybridized classification model for Hypoxia-Ischemia and Hypoglycemia, Epilepsy brain injury (HCM-BI). A Support Vector Machine is applied with clinical details to define the Hypoxia-Ischemia outcomes of each infant. The newborn babies are assessed every two years again to know the neural development results. A selection of four attributes is derived from the Electroencephalography records, and SVM does not get conclusions regarding the classification of diseases. The final feature extraction of the EEG signal is optimized by the Bayesian Neural Network (BNN) to get the clear health condition of Hypoglycemia and Epilepsy patients. Through monitoring and assessing physical effects resulting from Electroencephalography, The Bayesian Neural Network (BNN) is used to extract the test samples with the most log data and to report hypoglycemia and epilepsy Keywords- Hypoxia-Ischemia , Hypoglycemia , Epilepsy , Multilevel Fusion of Data Features , Bayesian Neural Network (BNN) , Support Vector Machine (SVM)

This research paper presents a novel approach to the prediction of hypoxia in brain tumors, using multi-parametric Magnetic Resonance Imaging (MRI). Hypoxia, a condition characterized by low oxygen levels, is a common feature of malignant brain tumors associated with poor prognosis. Fluoromisonidazole Positron Emission Tomography (FMISO PET) is a well-established method for detecting hypoxia in vivo, but it is expensive and not widely available. Our study proposes the use of MRI, a more accessible and cost-effective imaging modality, to predict FMISO PET signals. We investigate deep learning models (DL) trained on the ACRIN 6684 dataset, a resource that contains paired MRI and FMISO PET images from patients with brain tumors. Our trained models effectively learn the complex relationships between the MRI features and the corresponding FMISO PET signals, thereby enabling the prediction of hypoxia from MRI scans alone. The results show a strong correlation between the predicted and actual FMISO PET signals, with an overall PSNR score above 29.6 and a SSIM score greater than 0.94, confirming MRI as a promising option for hypoxia prediction in brain tumors. This approach could significantly improve the accessibility of hypoxia detection in clinical settings, with the potential for more timely and targeted treatments.

Hypoxia occurs when tumour cells outgrow their blood supply, leading to regions of low oxygen levels within the tumour. Calculating hypoxia levels can be an important step in understanding the biology of tumours, their clinical progression and response to treatment. This study demonstrates a novel application of deep learning to evaluate hypoxia in the context of breast cancer histomorphology. More precisely, we show that Weakly Supervised Deep Learning (WSDL) models can accurately detect hypoxia associated features in routine Hematoxylin and Eosin (H&E) whole slide images (WSI). We trained and evaluated a deep Multiple Instance Learning model on tiles from WSI H&E tissue from breast cancer primary sites (n=240) obtaining on average an AUC of 0.87 on a left-out test set. We also showed significant differences between features of hypoxic and normoxic tissue regions as distinguished by the WSDL models. Such DL hypoxia H&E WSI detection models could potentially be extended to other tumour types and easily integrated into the pathology workflow without requiring additional costly assays.

A new artificial intelligence system developed by researchers at the University of Washington uses patient data to predict whether patients are at risk of abnormally low blood oxygen (hypoxia) during surgery. University of Washington (UW) researchers have developed an artificial intelligence (AI) system that uses patient data to predict whether patients are at risk of abnormally low blood oxygen (hypoxia) during surgery. The Prescience system also provides users with real-world explanations to support and explain its predictions. In collaboration with physicians, UW's Su-In Lee and colleagues trained Prescience on about 50,000 patient files, so the program could analyze data such as patient age and weight to calculate the likelihood of hypoxemia prior to surgery. The system also uses real-time data during surgery to predict when patients are in danger of hypoxemia, and a new AI model helps Prescience provide doctors a concise description of the prediction's underlying factors.