In recent years, there has been growing interest in developing robots and autonomous systems that can interact with human in a more natural and intuitive way. One of the key challenges in achieving this goal is to enable these systems to manipulate objects and tools in a manner that is similar to that of humans. In this paper, we propose a novel approach for learning human-style manipulation skills by using adversarial motion priors, which we name HMAMP. The approach leverages adversarial networks to model the complex dynamics of tool and object manipulation, as well as the aim of the manipulation task. The discriminator is trained using a combination of real-world data and simulation data executed by the agent, which is designed to train a policy that generates realistic motion trajectories that match the statistical properties of human motion. We evaluated HMAMP on one challenging manipulation task: hammering, and the results indicate that HMAMP is capable of learning human-style manipulation skills that outperform current baseline methods. Additionally, we demonstrate that HMAMP has potential for real-world applications by performing real robot arm hammering tasks. In general, HMAMP represents a significant step towards developing robots and autonomous systems that can interact with humans in a more natural and intuitive way, by learning to manipulate tools and objects in a manner similar to how humans do.

Antimicrobial peptides (AMPs) have exhibited unprecedented potential as biomaterials in combating multidrug-resistant bacteria. Despite the increasing adoption of artificial intelligence for novel AMP design, challenges pertaining to conflicting attributes such as activity, hemolysis, and toxicity have significantly impeded the progress of researchers. This paper introduces a paradigm shift by considering multiple attributes in AMP design. Presented herein is a novel approach termed Hypervolume-driven Multi-objective Antimicrobial Peptide Design (HMAMP), which prioritizes the simultaneous optimization of multiple attributes of AMPs. By synergizing reinforcement learning and a gradient descent algorithm rooted in the hypervolume maximization concept, HMAMP effectively expands exploration space and mitigates the issue of pattern collapse. This method generates a wide array of prospective AMP candidates that strike a balance among diverse attributes. Furthermore, we pinpoint knee points along the Pareto front of these candidate AMPs. Empirical results across five benchmark models substantiate that HMAMP-designed AMPs exhibit competitive performance and heightened diversity. A detailed analysis of the helical structures and molecular dynamics simulations for ten potential candidate AMPs validates the superiority of HMAMP in the realm of multi-objective AMP design. The ability of HMAMP to systematically craft AMPs considering multiple attributes marks a pioneering milestone, establishing a universal computational framework for the multi-objective design of AMPs.