CAR-T cell therapy is already a potent treatment for certain cancers. Now, a small study is showing early promise for managing HIV. A Miracle cancer therapy that involves engineering a patient's own immune cells is being repurposed for HIV, and early results from two individuals hint at its promise for long-term control of the virus. As part of a clinical trial, scientists took people's own immune cells and reprogrammed them in a lab to recognize and attack HIV in the body. After a single infusion of the modified cells, two individuals with HIV now have undetectable levels of the virus--one for nearly two years and the other for almost a year.

Objective: To characterize stigma dimensions, social, and related behavioral circumstances in people living with HIV(PLWHs) seeking care, using NLP methods applied to a large collection of EHR clinical notes from a large integrated health system in the southeast United States. Methods: We identified a cohort of PLWHs from the UF Health IDR and performed topic modeling analysis using Latent Dirichlet Allocation to uncover stigma-related dimensions and related social and behavioral contexts. Domain experts created a seed list of HIV-related stigma keywords, then applied a snowball strategy to review notes for additional terms until saturation was reached iteratively. To identify more target topics, we tested three keyword-based filtering strategies. The detected topics were evaluated using three widely used metrics and manually reviewed by specialists. In addition, we conducted word frequency analysis and topic variation analysis among subgroups to examine differences across age and sex-specific demographics. Results: We identified 9140 PLWHs at UF Health and collected 2.9 million clinical notes. Through the iterative keyword approach, we generated a list of 91 keywords associated with HIV-related stigma. Topic modeling on sentences containing at least one keyword uncovered a wide range of topic themes, such as "Mental Health Concern, Stigma", "Treatment Refusal, Isolation", and "Substance Abuse". Topic variation analysis across age subgroups revealed substantial differences. Conclusion: Extracting and understanding the HIV-related stigma and associated social and behavioral circumstances from EHR clinical notes enables scalable, time-efficient assessment and overcoming the limitations of traditional questionnaires. Findings from this research provide actionable insights to inform patient care and interventions to improve HIV-care outcomes.

Autonomous agents play a crucial role in advancing Artificial General Intelligence, enabling problem decomposition and tool orchestration through Large Language Models (LLMs). However, existing paradigms face a critical trade-off. On one hand, reusable fixed workflows require manual reconfiguration upon environmental changes; on the other hand, flexible reactive loops fail to distill reasoning progress into transferable structures. We introduce Hierarchical V ariable Agent (HiV A), a novel framework modeling agentic workflows as self-organized graphs with the Semantic-Topological Evolution (STEV) algorithm, which optimizes hybrid semantic-topological spaces using textual gradients as discrete-domain surrogates for backpropagation. The iterative process comprises Multi-Armed Bandit-infused forward routing, diagnostic gradient generation from environmental feedback, and coordinated updates that co-evolve individual semantics and topology for collective optimization in unknown environments. Experiments on dialogue, coding, Long-context Q&A, mathematical, and agentic benchmarks demonstrate improvements of 5-10% in task accuracy and enhanced resource efficiency over existing baselines, establishing HiV A's effectiveness in autonomous task execution.

Human immunodeficiency virus (HIV) is a major public health concern in the United States, with about 1.2 million people living with HIV and 35,000 newly infected each year. There are considerable geographical disparities in HIV burden and care access across the U.S. The 2019 Ending the HIV Epidemic (EHE) initiative aims to reduce new infections by 90% by 2030, by improving coverage of diagnoses, treatment, and prevention interventions and prioritizing jurisdictions with high HIV prevalence. Identifying optimal scale-up of intervention combinations will help inform resource allocation. Existing HIV decision analytic models either evaluate specific cities or the overall national population, thus overlooking jurisdictional interactions or differences. In this paper, we propose a multi-agent reinforcement learning (MARL) model, that enables jurisdiction-specific decision analyses but in an environment with cross-jurisdictional epidemiological interactions. In experimental analyses, conducted on jurisdictions within California and Florida, optimal policies from MARL were significantly different than those generated from single-agent RL, highlighting the influence of jurisdictional variations and interactions. By using comprehensive modeling of HIV and formulations of state space, action space, and reward functions, this work helps demonstrate the strengths and applicability of MARL for informing public health policies, and provides a framework for expanding to the national-level to inform the EHE.

Introduction: The value of integrating federal HIV services data with HIV surveillance is currently unknown. Upstream and complete case capture is essential in preventing future HIV transmission. Methods: This study integrated Ryan White, Social Security Disability Insurance, Medicare, Children Health Insurance Programs and Medicaid demographic aggregates from 2005 to 2018 for people living with HIV and compared them with Centers for Disease Control and Prevention HIV surveillance by demographic aggregate. Surveillance Unknown, Service Known (SUSK) candidate aggregates were identified from aggregates where services aggregate volumes exceeded surveillance aggregate volumes. A distribution approach and a deep learning model series were used to identify SUSK candidate aggregates where surveillance cases exceeded services cases in aggregate. Results: Medicare had the most candidate SUSK aggregates. Medicaid may have candidate SUSK aggregates where cases approach parity with surveillance. Deep learning was able to detect candidate SUSK aggregates even where surveillance cases exceed service cases. Conclusions: Integration of CMS case level records with HIV surveillance records can increase case discovery and life course model quality; especially for cases who die after seeking HIV services but before they become surveillance cases. The ethical implications for both the availability and reuse of clinical HIV Data without the knowledge and consent of the persons described remains an opportunity for the development of big data ethics in public health research. Future work should develop big data ethics to support researchers and assure their subjects that information which describes them is not misused.

After 38 years as the head of the National Institute of Allergy and Infectious Diseases, Dr. Anthony Fauci announced on Monday that he will be stepping down from his role in December. Appointed to the position in 1984 by then-president Ronald Reagan, Fauci has personally overseen the federal government's response to some of the 20th century's deadliest infectious diseases -- from tuberculosis and COVID to SARS and MERS. But, as he told The Guardian in 2020, "my career and my identity has really been defined by HIV." The prevention and treatment of HIV has been a prioritized area of research for the NIAID since 1986, and one that Dr. Fauci has devoted much of his public service to. The current state of AIDS research and response in America is thanks in no small part to his continued efforts in the field.

With new coronavirus variants cropping up seemingly by the day, it's urgent that vaccines and public health efforts be able to stay ahead of the pandemic. Unfortunately, mutations are random, and it's usually impossible to predict what their impact will be when they do occur. The trouble, basically, is that we don't speak virus. "When you say a sentence, it's not just a random jumble of words," says Brian Hie, a doctoral student at MIT. There is structure that corresponds to grammar and other rules, he says.

Probability is the cornerstone of Artificial Intelligence. The management of uncertainty is key to many applications of AI, such as machine learning, filtering, robotics, computer vision, NLP, search and so on. And no other sector is the management of uncertainty as crucial as it is in the health sector. At first glance, the false-negative seems more devastating. Of course, a false allergy test-result has the likely outcome of a GP administering a drug to you that could cause life-threatening issues.

Unnecessary restrictions on blood donors should be removed to maximize the blood and plasma available for use. With a vaccine for coronavirus disease 2019 (COVID-19) likely more than a year away, we must identify effective therapies for patients now. One promising approach is the use of plasma from patients who have recovered from COVID-19 (1, 2). To facilitate this strategy, the U.S. Food and Drug Administration (FDA) recently revised some of the restrictions on blood donation, including a decrease in deferral time for men who have sex with men (MSM) to 3 months (3). This is a positive change to an outdated guideline, but it does not go far enough.

BEIJING - Chinese gay dating app Blued is halting new user registration for a week, it said Sunday, following media reports that underage users caught HIV after going on dates set up via the world's largest networking app for the LGBT community. China has a vibrant lesbian, gay, bisexual and transgender scene, though activists say conservative attitudes among some groups in society have prompted occasional government clampdowns. On Saturday, citing academic research, financial magazine Caixin said juveniles were heavily involved in the gay dating app, where some teenagers had even hosted live-streaming. It added that many gay teenagers had unprotected sex through the app and contracted HIV, the virus that causes AIDS. In response, Blued vowed to launch a "comprehensive content audit and regulation," and crack down on juvenile users posing as adults and on texts, pictures and groups that involve minors.