We describe how we used a data set of chorale harmonisations composed by Johann Sebastian Bach to train Hidden Markov Models. Using a prob- abilistic framework allows us to create a harmonisation system which learns from examples, and which can compose new harmonisations. We make a quantitative comparison of our system's harmonisation perfor- mance against simpler models, and provide example harmonisations.

Removing the bias and variance of multicentre data has always been a challenge in large scale digital healthcare studies, which requires the ability to integrate clinical features extracted from data acquired by different scanners and protocols to improve stability and robustness. Previous studies have described various computational approaches to fuse single modality multicentre datasets. However, these surveys rarely focused on evaluation metrics and lacked a checklist for computational data harmonisation studies. In this systematic review, we summarise the computational data harmonisation approaches for multi-modality data in the digital healthcare field, including harmonisation strategies and evaluation metrics based on different theories. In addition, a comprehensive checklist that summarises common practices for data harmonisation studies is proposed to guide researchers to report their research findings more effectively. Last but not least, flowcharts presenting possible ways for methodology and metric selection are proposed and the limitations of different methods have been surveyed for future research.

When he died in 1827 aged 56, Ludwig van Beethoven left his 10th symphony unfinished. Only a few handwritten notes briefly detailing his plans for the piece have survived, with most just being incomplete ideas or fragments of themes or melodies. Now, a multidisciplinary team of computer scientists at Rutgers University-based start-up Playform AI have trained an artificial intelligence to mimic the great composer's style and used it to write a complete symphony based on these initial sketches. We spoke to the lead researcher on the project, Professor Ahmed Elgammal, to find out more. Beethoven left sketches in different forms, mainly musical sketches, but also some written notes with some ideas in as well.

We describe how we used a data set of chorale harmonisations composed by Johann Sebastian Bach to train Hidden Markov Models. Using a probabilistic framework allows us to create a harmonisation system which learns from examples, and which can compose new harmonisations. We make a quantitative comparison of our system's harmonisation performance against simpler models, and provide example harmonisations.

Section 2 below gives an overview of the musical background to chorale harmonisation. Section 3 explains how we can create a harmonisation system using Hidden Markov Models. Section 4 examines the system's performance quantitatively and provides example

We describe how we used a data set of chorale harmonisations composed by Johann Sebastian Bach to train Hidden Markov Models. Using a probabilistic framework allows us to create a harmonisation system which learns from examples, and which can compose new harmonisations. We make a quantitative comparison of our system's harmonisation performance against simpler models, and provide example harmonisations.