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Average Controlled and Average Natural Micro Direct Effects in Summary Causal Graphs
Ferreira, Simon, Assaad, Charles K.
In this paper, we investigate the identifiability of average controlled direct effects and average natural direct effects in causal systems represented by summary causal graphs, which are abstractions of full causal graphs, often used in dynamic systems where cycles and omitted temporal information complicate causal inference. Unlike in the traditional linear setting, where direct effects are typically easier to identify and estimate, non-parametric direct effects, which are crucial for handling real-world complexities, particularly in epidemiological contexts where relationships between variables (e.g, genetic, environmental, and behavioral factors) are often non-linear, are much harder to define and identify. In particular, we give sufficient conditions for identifying average controlled micro direct effect and average natural micro direct effect from summary causal graphs in the presence of hidden confounding. Furthermore, we show that the conditions given for the average controlled micro direct effect become also necessary in the setting where there is no hidden confounding and where we are only interested in identifiability by adjustment.
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- Health & Medicine > Therapeutic Area (0.68)
- Health & Medicine > Epidemiology (0.46)
Identifying macro conditional independencies and macro total effects in summary causal graphs with latent confounding
Ferreira, Simon, Assaad, Charles K.
Understanding causal relationships in dynamic systems is essential for numerous scientific fields, including epidemiology, economics, and biology. While causal inference methods have been extensively studied, they often rely on fully specified causal graphs, which may not always be available or practical in complex dynamic systems. Partially specified causal graphs, such as summary causal graphs (SCGs), provide a simplified representation of causal relationships, omitting temporal information and focusing on high-level causal structures. This simplification introduces new challenges concerning the types of queries of interest: macro queries, which involve relationships between clusters represented as vertices in the graph, and micro queries, which pertain to relationships between variables that are not directly visible through the vertices of the graph. In this paper, we first clearly distinguish between macro conditional independencies and micro conditional independencies and between macro total effects and micro total effects. Then, we demonstrate the soundness and completeness of the d-separation to identify macro conditional independencies in SCGs. Furthermore, we establish that the do-calculus is sound and complete for identifying macro total effects in SCGs. Conversely, we also show through various examples that these results do not hold when considering micro conditional independencies and micro total effects.
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- Health & Medicine > Therapeutic Area > Infections and Infectious Diseases (1.00)
- Health & Medicine > Therapeutic Area > Immunology (1.00)
- Health & Medicine > Epidemiology (1.00)
Toward identifiability of total effects in summary causal graphs with latent confounders: an extension of the front-door criterion
Conducting experiments to estimate total effects can be challenging due to cost, ethical concerns, or practical limitations. As an alternative, researchers often rely on causal graphs to determine if it is possible to identify these effects from observational data. Identifying total effects in fully specified non-temporal causal graphs has garnered considerable attention, with Pearl's front-door criterion enabling the identification of total effects in the presence of latent confounding even when no variable set is sufficient for adjustment. However, specifying a complete causal graph is challenging in many domains. Extending these identifiability results to partially specified graphs is crucial, particularly in dynamic systems where causal relationships evolve over time. This paper addresses the challenge of identifying total effects using a specific and well-known partially specified graph in dynamic systems called a summary causal graph, which does not specify the temporal lag between causal relations and can contain cycles. In particular, this paper presents sufficient graphical conditions for identifying total effects from observational data, even in the presence of hidden confounding and when no variable set is sufficient for adjustment, contributing to the ongoing effort to understand and estimate causal effects from observational data using summary causal graphs.
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