Some data from multiple sources can be modeled as multimodal time-series events which have different sampling frequencies, data compositions, temporal relations and characteristics. Different types of events have complex nonlinear relationships, and the time of each event is irregular. Neither the classical Recurrent Neural Network (RNN) model nor the current state-of-the-art Transformer model can deal with these features well. In this paper, a features fusion framework for multimodal irregular time-series events is proposed based on the Long Short-Term Memory networks (LSTM). Firstly, the complex features are extracted according to the irregular patterns of different events. Secondly, the nonlinear correlation and complex temporal dependencies relationship between complex features are captured and fused into a tensor. Finally, a feature gate are used to control the access frequency of different tensors. Extensive experiments on MIMIC-III dataset demonstrate that the proposed framework significantly outperforms to the existing methods in terms of AUC (the area under Receiver Operating Characteristic curve) and AP (Average Precision).

Time series data are prevalent in electronic health records, mostly in the form of physiological parameters such as vital signs and lab tests. The patterns of these values may be significant indicators of patients' clinical states and there might be patterns that are unknown to clinicians but are highly predictive of some outcomes. Many of these values are also missing which makes it difficult to apply existing methods like decision trees. We propose a recurrent neural network model that reduces overfitting to noisy observations by limiting interactions between features. We analyze its performance on mortality, ICD-9 and AKI prediction from observational values on the Medical Information Mart for Intensive Care III (MIMIC-III) dataset. Our models result in an improvement of 1.1% [p<0.01] in AU-ROC for mortality prediction under the MetaVision subset and 1.0% and 2.2% [p<0.01] respectively for mortality and AKI under the full MIMIC-III dataset compared to existing state-of-the-art interpolation, embedding and decay-based recurrent models.