Learning depends on changes in synaptic connections deep inside the brain. In multilayer networks, these changes are triggered by error signals fed back from the output, generally through a stepwise inversion of the feedforward processing steps. The gold standard for this process --- backpropagation --- works well in artificial neural networks, but is biologically implausible. Several recent proposals have emerged to address this problem, but many of these biologically-plausible schemes are based on learning an independent set of feedback connections. This complicates the assignment of errors to each synapse by making it dependent upon a second learning problem, and by fitting inversions rather than guaranteeing them.

How do brain circuits learn to generate behaviour? While significant strides have been made in understanding learning in artificial neural networks, applying this knowledge to biological networks remains challenging. For instance, while backpropagation is known to perform accurate credit assignment of error in artificial neural networks, how a similarly powerful process can be realized within the constraints of biological circuits remains largely unclear. One of the major challenges is that the brain's extensive recurrent connectivity requires the propagation of error through both space and time, a problem that is notoriously difficult to solve in vanilla recurrent neural networks. Moreover, the extensive feedback connections in the brain are known to influence forward network activity, but the interaction between feedback-driven activity changes and local, synaptic plasticity-based learning is not fully understood. Building on our previous work modelling motor learning, this work investigates the mechanistic properties of pre-trained networks with feedback control on a standard motor task. We show that feedback control of the ongoing recurrent network dynamics approximates the optimal first-order gradient with respect to the network activities, allowing for rapid, ongoing movement correction. Moreover, we show that trial-by-trial adaptation to a persistent perturbation using a local, biologically plausible learning rule that integrates recent activity and error feedback is both more accurate and more efficient with feedback control during learning, due to the decoupling of the recurrent network dynamics and the injection of an adaptive, second-order gradient into the network dynamics. Thus, our results suggest that feedback control may guide credit assignment in biological recurrent neural networks, enabling both rapid and efficient learning in the brain.

A major problem in motor control is understanding how the brain plans and executes proper movements in the face of delayed and noisy stimuli.

How do brain circuits learn to generate behaviour?

How do brain circuits learn to generate behaviour?

Budget pacing is critical in online advertising to align spend with campaign goals under dynamic auctions. Existing pacing methods often rely on ad-hoc parameter tuning, which can be unstable and inefficient. We propose a principled controller that combines bucketized hysteresis with proportional feedback to provide stable and adaptive spend control. Our method provides a framework and analysis for parameter selection that enables accurate tracking of desired spend rates across campaigns. Experiments in real-world auctions demonstrate significant improvements in pacing accuracy and delivery consistency, reducing pacing error by 13% and $λ$-volatility by 54% compared to baseline method. By bridging control theory with advertising systems, our approach offers a scalable and reliable solution for budget pacing, with particular benefits for small-budget campaigns.

Biomolecular Neural Networks (BNNs), artificial neural networks with biologically synthesizable architectures, achieve universal function approximation capabilities beyond simple biological circuits. However, training BNNs remains challenging due to the lack of target data. To address this, we propose leveraging Signal Temporal Logic (STL) specifications to define training objectives for BNNs. We build on the quantitative semantics of STL, enabling gradient-based optimization of the BNN weights, and introduce a learning algorithm that enables BNNs to perform regression and control tasks in biological systems. Specifically, we investigate two regression problems in which we train BNNs to act as reporters of dysregulated states, and a feedback control problem in which we train the BNN in closed-loop with a chronic disease model, learning to reduce inflammation while avoiding adverse responses to external infections. Our numerical experiments demonstrate that STL-based learning can solve the investigated regression and control tasks efficiently.

The experiments to produce the figures of the paper were performed on a Linux-based (CentOS) desktop with Intel Xeon CPU E5-2643 v4 @ 3.40GHz (6 cores) and 128 GB of RAM. To produce Figs. 4 and 5 (also supporting Figs. Requirements: python, matplotlib, numpy, scipy The hyperparameters obtained with optuna [2] are provided in the subdirectory results. To recreate a figure run the corresponding script. Bio-OFC is an instance of such a controller.