Time series classification (TSC) is crucial in numerous real-world applications, such as environmental monitoring, medical diagnosis, and posture recognition. TSC tasks require models to effectively capture discriminative information for accurate class identification. Although deep learning architectures excel at capturing temporal dependencies, they often suffer from high computational cost, sensitivity to noise perturbations, and susceptibility to overfitting on small-scale datasets. To address these challenges, we propose FAIM, a lightweight Frequency-Aware Interactive Mamba model. Specifically, we introduce an Adaptive Filtering Block (AFB) that leverages Fourier Transform to extract frequency-domain features from time series data. The AFB incorporates learnable adaptive thresholds to dynamically suppress noise and employs element-wise coupling of global and local semantic adaptive filtering, enabling in-depth modeling of the synergy among different frequency components. Furthermore, we design an Interactive Mamba Block (IMB) to facilitate efficient multi-granularity information interaction, balancing the extraction of fine-grained discriminative features and comprehensive global contextual information, thereby endowing FAIM with powerful and expressive representations for TSC tasks. Additionally, we incorporate a self-supervised pre-training mechanism to enhance FAIM's understanding of complex temporal patterns and improve its robustness across various domains and high-noise scenarios. Extensive experiments on multiple benchmarks demonstrate that FAIM consistently outperforms existing state-of-the-art (SOTA) methods, achieving a superior trade-off between accuracy and efficiency and exhibits outstanding performance.

The escalating integration of machine learning in high-stakes fields such as healthcare raises substantial concerns about model fairness. We propose an interpretable framework - Fairness-Aware Interpretable Modeling (FAIM), to improve model fairness without compromising performance, featuring an interactive interface to identify a "fairer" model from a set of high-performing models and promoting the integration of data-driven evidence and clinical expertise to enhance contextualized fairness. We demonstrated FAIM's value in reducing sex and race biases by predicting hospital admission with two real-world databases, MIMIC-IV-ED and SGH-ED. We show that for both datasets, FAIM models not only exhibited satisfactory discriminatory performance but also significantly mitigated biases as measured by well-established fairness metrics, outperforming commonly used bias-mitigation methods. Our approach demonstrates the feasibility of improving fairness without sacrificing performance and provides an a modeling mode that invites domain experts to engage, fostering a multidisciplinary effort toward tailored AI fairness.

Deformable image registration is fundamental for many medical image analyses. A key obstacle for accurate image registration is the variations in image appearance. Recently, deep learning-based registration methods (DLRs), using deep neural networks, have computational efficiency that is several orders of magnitude greater than traditional optimization-based registration methods (ORs). A major drawback, however, of DLRs is a disregard for the target-pair-specific optimization that is inherent in ORs and instead they rely on a globally optimized network that is trained with a set of training samples to achieve faster registration. Thus, DLRs inherently have degraded ability to adapt to appearance variations and perform poorly, compared to ORs, when image pairs (fixed/moving images) have large differences in appearance. Hence, we propose an Appearance Adjustment Network (AAN) where we leverage anatomy edges, through an anatomy-constrained loss function, to generate an anatomy-preserving appearance transformation. We designed the AAN so that it can be readily inserted into a wide range of DLRs, to reduce the appearance differences between the fixed and moving images. Our AAN and DLR's network can be trained cooperatively in an unsupervised and end-to-end manner. We evaluated our AAN with two widely used DLRs - Voxelmorph (VM) and FAst IMage registration (FAIM) - on three public 3D brain magnetic resonance (MR) image datasets - IBSR18, Mindboggle101, and LPBA40. The results show that DLRs, using the AAN, improved performance and achieved higher results than state-of-the-art ORs.