Intracellular recordings in spinal cord motoneurons and cerebral cortex neurons have provided new evidence on the correlational strength of monosynaptic connections, and the relation between the shapes of postsynaptic potentials and the associated increased firing probability. In these cells, excitatory postsynaptic potentials (EPSPs) produce cross(cid:173) correlogram peaks which resemble in large part the derivative of the EPSP. Additional synaptic noise broadens the peak, but the peak area -- i.e., the number of above-chance firings triggered per EPSP -- remains proportional to the EPSP amplitude. A typical EPSP of 100 v triggers about .01 The consequences of these data for information processing by polysynaptic connections is discussed.

We derive an optimal learning rule in the sense of mutual information maximization for a spiking neuron model. Under the assumption of small fluctuations of the input, we find a spike-timing dependent plas- ticity (STDP) function which depends on the time course of excitatory postsynaptic potentials (EPSPs) and the autocorrelation function of the postsynaptic neuron. We show that the STDP function has both positive and negative phases. The positive phase is related to the shape of the EPSP while the negative phase is controlled by neuronal refractoriness.

It has remained unknown whether one can in principle carry out reliable digital computations with networks of biologically realistic models for neurons. This article presents rigorous constructions for simulating in real-time arbitrary given boolean circuits and finite automata with arbitrarily high reliability by networks of noisy spiking neurons. In addition we show that with the help of "shunting inhibition" even networks of very unreliable spiking neurons can simulate in real-time any McCulloch-Pitts neuron (or "threshold gate"), and therefore any multilayer perceptron (or "threshold circuit") in a reliable manner. These constructions provide a possible explanation for the fact that biological neural systems can carry out quite complex computations within 100 msec. It turns out that the assumption that these constructions require about the shape of the EPSP's and the behaviour of the noise are surprisingly weak. 1 Introduction

It has remained unknown whether one can in principle carry out reliable digital computations with networks of biologically realistic models for neurons. This article presents rigorous constructions for simulating in real-time arbitrary given boolean circuits and finite automatawith arbitrarily high reliability by networks of noisy spiking neurons. In addition we show that with the help of "shunting inhibition" even networks of very unreliable spiking neurons can simulate in real-time any McCulloch-Pitts neuron (or "threshold gate"), and therefore any multilayer perceptron (or "threshold circuit") in a reliable manner. These constructions provide a possible explanation forthe fact that biological neural systems can carry out quite complex computations within 100 msec. It turns out that the assumption that these constructions require about the shape of the EPSP's and the behaviour of the noise are surprisingly weak. 1 Introduction

Spiking neurons which integrate to threshold and fire were used to study the transmission of frequency modulated (FM) signals through layered networks. Firing correlations between cells in the input layer were found to modulate the transmission of FM signals undercertain dynamical conditions. A tonic level of activity was maintained by providing each cell with a source of Poissondistributed synapticinput. When the average membrane depolarization produced by the synaptic input was sufficiently below threshold, the firing correlations between cells in the input layer could greatly amplify the signal present in subsequent layers. When the depolarization was sufficiently close to threshold, however, the firing synchrony between cells in the initial layers could no longer effect the propagation of FM signals. In this latter case, integrateand-fire neuronscould be effectively modeled by simpler analog elements governed by a linear input-output relation.

Spiking neurons which integrate to threshold and fire were used to study the transmission of frequency modulated (FM) signals through layered networks. Firing correlations between cells in the input layer were found to modulate the transmission of FM signals under certain dynamical conditions. A tonic level of activity was maintained by providing each cell with a source of Poissondistributed synaptic input. When the average membrane depolarization produced by the synaptic input was sufficiently below threshold, the firing correlations between cells in the input layer could greatly amplify the signal present in subsequent layers. When the depolarization was sufficiently close to threshold, however, the firing synchrony between cells in the initial layers could no longer effect the propagation of FM signals. In this latter case, integrateand-fire neurons could be effectively modeled by simpler analog elements governed by a linear input-output relation.

Spiking neurons which integrate to threshold and fire were used to study the transmission of frequency modulated (FM) signals through layered networks. Firing correlations between cells in the input layer were found to modulate the transmission of FM signals under certain dynamical conditions. A tonic level of activity was maintained by providing each cell with a source of Poissondistributed synaptic input. When the average membrane depolarization produced by the synaptic input was sufficiently below threshold, the firing correlations between cells in the input layer could greatly amplify the signal present in subsequent layers. When the depolarization was sufficiently close to threshold, however, the firing synchrony between cells in the initial layers could no longer effect the propagation of FM signals. In this latter case, integrateand-fire neurons could be effectively modeled by simpler analog elements governed by a linear input-output relation.

ABSTRACT Intracellular recordings in spinal cord motoneurons and cerebral cortex neurons have provided new evidence on the correlational strength of monosynaptic connections, and the relation between the shapes of postsynaptic potentials and the associated increased firing probability. In these cells, excitatory postsynaptic potentials (EPSPs) produce crosscorrelogram peaks which resemble in large part the derivative of the EPSP. Additional synaptic noise broadens the peak, but the peak area -- i.e., the number of above-chance firings triggered per EPSP -- remains proportional to the EPSP amplitude. The consequences of these data for information processing by polysynaptic connections is discussed. The effects of sequential polysynaptic links can be calculated by convolving the effects of the underlying monosynaptic connections.

ABSTRACT Intracellular recordings in spinal cord motoneurons and cerebral cortex neurons have provided new evidence on the correlational strength of monosynaptic connections, and the relation between the shapes of postsynaptic potentials and the associated increased firing probability. In these cells, excitatory postsynaptic potentials (EPSPs) produce crosscorrelogram peaks which resemble in large part the derivative of the EPSP. Additional synaptic noise broadens the peak, but the peak area -- i.e., the number of above-chance firings triggered per EPSP -- remains proportional to the EPSP amplitude. The consequences of these data for information processing by polysynaptic connections is discussed. The effects of sequential polysynaptic links can be calculated by convolving the effects of the underlying monosynaptic connections.

Correlational Strength and Computational Algebra of Synaptic Connections Between Neurons Eberhard E. Fetz Department of Physiology & Biophysics, University of Washington, Seattle, WA 98195 ABSTRACT Intracellular recordings in spinal cord motoneurons and cerebral cortex neurons have provided new evidence on the correlational strength of monosynaptic connections, and the relation between the shapes of postsynaptic potentials and the associated increased firing probability. In these cells, excitatory postsynaptic potentials (EPSPs) produce crosscorrelogram peakswhich resemble in large part the derivative of the EPSP. Additional synaptic noise broadens the peak, but the peak area -- i.e., the number of above-chance firings triggered per EPSP -- remains proportional to the EPSP amplitude. The consequences of these data for information processing by polysynaptic connections is discussed. The effects of sequential polysynaptic links can be calculated by convolving the effects of the underlying monosynaptic connections.