Large language models (LLMs) deployed in user-facing applications require long-horizon consistency: the ability to remember prior interactions, respect user preferences, and ground reasoning in past events. However, contemporary memory systems often adopt complex architectures such as knowledge graphs, multi-stage retrieval pipelines, and OS-style schedulers, which introduce engineering complexity and reproducibility challenges. We present ENGRAM, a lightweight memory system that organizes conversation into three canonical memory types (episodic, semantic, and procedural) through a single router and retriever. Each user turn is converted into typed memory records with normalized schemas and embeddings and stored in a database. At query time, the system retrieves top-k dense neighbors for each type, merges results with simple set operations, and provides the most relevant evidence as context to the model. ENGRAM attains state-of-the-art results on LoCoMo, a multi-session conversational QA benchmark for long-horizon memory, and exceeds the full-context baseline by 15 points on LongMemEval while using only about 1% of the tokens. These results show that careful memory typing and straightforward dense retrieval can enable effective long-term memory management in language models without requiring complex architectures.

Despite substantial research into the biological basis of memory, the precise mechanisms by which experiences are encoded, stored, and retrieved in the brain remain incompletely understood. A growing body of evidence supports the engram theory, which posits that sparse populations of neurons undergo lasting physical and biochemical changes to support long-term memory. Yet, a comprehensive computational framework that integrates biological findings with mechanistic models remains elusive. This work synthesizes insights from cellular neuroscience and computational modeling to address key challenges in engram research: how engram neurons are identified and manipulated; how synaptic plasticity mechanisms contribute to stable memory traces; and how sparsity promotes efficient, interference-resistant representations. Relevant computational approaches -- such as sparse regularization, engram gating, and biologically inspired architectures like Sparse Distributed Memory and spiking neural networks -- are also examined. Together, these findings suggest that memory efficiency, capacity, and stability emerge from the interaction of plasticity and sparsity constraints. By integrating neurobiological and computational perspectives, this paper provides a comprehensive theoretical foundation for engram research and proposes a roadmap for future inquiry into the mechanisms underlying memory, with implications for the diagnosis and treatment of memory-related disorders.

Cognitive neuroscience research indicates that humans leverage cues to activate entity-centered memory traces (engrams) for complex, multi-hop recollection. Inspired by this mechanism, we introduce EcphoryRAG, an entity-centric knowledge graph RAG framework. During indexing, EcphoryRAG extracts and stores only core entities with corresponding metadata, a lightweight approach that reduces token consumption by up to 94\% compared to other structured RAG systems. For retrieval, the system first extracts cue entities from queries, then performs a scalable multi-hop associative search across the knowledge graph. Crucially, EcphoryRAG dynamically infers implicit relations between entities to populate context, enabling deep reasoning without exhaustive pre-enumeration of relationships. Extensive evaluations on the 2WikiMultiHop, HotpotQA, and MuSiQue benchmarks demonstrate that EcphoryRAG sets a new state-of-the-art, improving the average Exact Match (EM) score from 0.392 to 0.474 over strong KG-RAG methods like HippoRAG. These results validate the efficacy of the entity-cue-multi-hop retrieval paradigm for complex question answering.

In the age of generative AI and ubiquitous digital tools, human cognition faces a structural paradox: as external aids become more capable, internal memory systems risk atrophy. Drawing on neuroscience and cognitive psychology, this paper examines how heavy reliance on AI systems and discovery-based pedagogies may impair the consolidation of declarative and procedural memory -- systems essential for expertise, critical thinking, and long-term retention. We review how tools like ChatGPT and calculators can short-circuit the retrieval, error correction, and schema-building processes necessary for robust neural encoding. Notably, we highlight striking parallels between deep learning phenomena such as "grokking" and the neuroscience of overlearning and intuition. Empirical studies are discussed showing how premature reliance on AI during learning inhibits proceduralization and intuitive mastery. We argue that effective human-AI interaction depends on strong internal models -- biological "schemata" and neural manifolds -- that enable users to evaluate, refine, and guide AI output. The paper concludes with policy implications for education and workforce training in the age of large language models.

The ability to learn continuously in artificial neural networks (ANNs) is often limited by catastrophic forgetting, a phenomenon in which new knowledge becomes dominant. By taking mechanisms of memory encoding in neuroscience (aka. engrams) as inspiration, we propose a novel approach that integrates stochastically-activated engrams as a gating mechanism for metaplastic binarized neural networks (mBNNs). This method leverages the computational efficiency of mBNNs combined with the robustness of probabilistic memory traces to mitigate forgetting and maintain the model's reliability. Previously validated metaplastic optimization techniques have been incorporated to enhance synaptic stability further. Compared to baseline binarized models and benchmark fully connected continual learning approaches, our method is the only strategy capable of reaching average accuracies over 20% in class-incremental scenarios and achieving comparable domain-incremental results to full precision state-of-the-art methods. Furthermore, we achieve a significant reduction in peak GPU and RAM usage, under 5% and 20%, respectively. Our findings demonstrate (A) an improved stability vs. plasticity trade-off, (B) a reduced memory intensiveness, and (C) an enhanced performance in binarized architectures. By uniting principles of neuroscience and efficient computing, we offer new insights into the design of scalable and robust deep learning systems.

In our previous work, we proposed that engrams in the brain could be biologically implemented as autoencoders over recurrent neural networks. These autoencoders would comprise basic excitatory/inhibitory motifs, with credit assignment deriving from a simple homeostatic criterion. This brief note examines the relevance of the latent space in these autoencoders. We consider the relationship between the dimensionality of these autoencoders and the complexity of the information being encoded. We discuss how observed differences between species in their connectome could be linked to their cognitive capacities. Finally, we link this analysis with a basic but often overlooked fact: human cognition is likely limited by our own brain structure. However, this limitation does not apply to machine learning systems, and we should be aware of the need to learn how to exploit this augmented vision of the nature.

Transformer-based models still face the structural limitation of fixed context length in processing long sequence input despite their effectiveness in various fields. While various external memory techniques were introduced, most previous techniques fail to avoid fateful forgetting, where even the most important memories are inevitably forgotten after a sufficient number of time steps. We designed Memoria, a memory system for artificial neural networks, drawing inspiration from humans and applying various neuroscientific and psychological theories related to memory. Experimentally, we demonstrated the effectiveness of Memoria in tasks such as sorting and language modeling, surpassing conventional techniques.

Despite evidence for the existence of engrams as memory support structures in our brains, there is no consensus framework in neuroscience as to what their physical implementation might be. Here we propose how we might design a computer system to implement engrams using neural networks, with the main aim of exploring new ideas using machine learning techniques, guided by challenges in neuroscience. Building on autoencoders, we propose latent neural spaces as indexes for storing and retrieving information in a compressed format. We consider this technique as a first step towards predictive learning: autoencoders are designed to compare reconstructed information with the original information received, providing a kind of predictive ability, which is an attractive evolutionary argument. We then consider how different states in latent neural spaces corresponding to different types of sensory input could be linked by synchronous activation, providing the basis for a sparse implementation of memory using concept neurons. Finally, we list some of the challenges and questions that link neuroscience and data science and that could have implications for both fields, and conclude that a more interdisciplinary approach is needed, as many scientists have already suggested.

Hebbian theory is a neuroscientific theory claiming that an increase in synaptic efficacy arises from a presynaptic cell's repeated and persistent stimulation of a postsynaptic cell. It is an attempt to explain synaptic plasticity, the adaptation of brain neurons during the learning process. It was introduced by Donald Hebb in his 1949 book The Organization of Behavior.[1] The theory is also called Hebb's rule, Hebb's postulate, and cell assembly theory. Let us assume that the persistence or repetition of a reverberatory activity (or "trace") tends to induce lasting cellular changes that add to its stability.

European Law now requires AI to be explainable in the context of adverse decisions affecting European Union (EU) citizens. At the same time, it is expected that there will be increasing instances of AI failure as it operates on imperfect data. This paper puts forward a neurally-inspired framework called decision stacks that can provide for a way forward in research aimed at developing explainable AI. Leveraging findings from memory systems in biological brains, the decision stack framework operationalizes the definition of explainability and then proposes a test that can potentially reveal how a given AI decision came to its conclusion.