Spatial transcriptomics (ST) is a groundbreaking genomic technology that enables spatial localization analysis of gene expression within tissue sections. However, it is significantly limited by high costs and sparse spatial resolution. An alternative, more cost-effective strategy is to use deep learning methods to predict high-density gene expression profiles from histological images. However, existing methods struggle to capture rich image features effectively or rely on low-dimensional positional coordinates, making it difficult to accurately predict high-resolution gene expression profiles. To address these limitations, we developed HisToSGE, a method that employs a Pathology Image Large Model (PILM) to extract rich image features from histological images and utilizes a feature learning module to robustly generate high-resolution gene expression profiles. We evaluated HisToSGE on four ST datasets, comparing its performance with five state-of-the-art baseline methods. The results demonstrate that HisToSGE excels in generating high-resolution gene expression profiles and performing downstream tasks such as spatial domain identification. All code and public datasets used in this paper are available at https://github.com/wenwenmin/HisToSGE and https://zenodo.org/records/12792163.

Demographic shifts have led to an increase in mild cognitive impairment (MCI), and this study investigates the effects of cognitive training (CT) and reminiscence therapy (RT) conducted by humans or socially assistive robots (SARs) on prefrontal cortex activation in elderly individuals with MCI, aiming to determine the most effective therapy-modality combination for promoting cognitive function. This pilot study employs a randomized control trial (RCT) design. Additionally, the study explores the efficacy of Reminiscence Therapy (RT) in comparison to Cognitive Training (CT). Eight MCI subjects, with a mean age of 70.125 years, were randomly assigned to ``human-led'' or ``SAR-led'' groups. Utilizing Functional Near-infrared Spectroscopy (fNIRS) to measure oxy-hemoglobin concentration changes in the dorsolateral prefrontal cortex (DLPFC), the study found no significant differences in the effects of human-led and SAR-led cognitive training on DLPFC activation. However, distinct patterns emerged in memory encoding and retrieval phases between RT and CT, shedding light on the impacts of these interventions on brain activation in the context of MCI.

Welcome to State of Mind, a section from Slate and Arizona State University dedicated to exploring mental health. I learned how to recognize strokes from TV. I must have seen the PSA urging me to "Act FAST" hundreds of times, slotted between episodes of Rugrats and Hey Arnold!, and I still recall the signs easily: facial droop, arm weakness, speech problems, timely response. Those PSAs have surely saved lives. According to the National Institutes of Health, 795,000 people have strokes each year in the U.S.; 137,000 of them die.

Welcome to State of Mind, a new section from Slate and Arizona State University dedicated to exploring mental health. When parents learn about Michael Milham's research, they often ask him, "Can you give my child a brain scan to figure out what's wrong with them?" Milham treats his young patients like any other child psychiatrist would: He observes and interviews them, assigns them diagnoses, and prescribes courses of treatment. But unlike many psychiatrists, Milham is also a scientist--he is vice president of research at the Child Mind Institute--and an expert on functional magnetic resonance imaging, or fMRI, a tool that allows researchers to measure levels of activity across the brain. He understands why parents want him to scan their children's brains. For families in search of an explanation for their child's distress, the inexactitude of psychiatry--its overlapping diagnoses, its uncertain prognoses--can be frustrating.

Here we build a hierarchical modular network called Language guided machine action (LGMA), whose modules process information stream mimicking human cortical network that allows to achieve multiple general tasks such as language guided action, intention decomposition and mental simulation before action execution etc. LGMA contains 3 main systems: (1) primary sensory system that multimodal sensory information of vision, language and sensorimotor. (2) association system involves and Broca modules to comprehend and synthesize language, BA14/40 module to translate between sensorimotor and language, midTemporal module to convert between language and vision, and superior parietal lobe to integrate attended visual object and arm state into cognitive map for future spatial actions. Pre-supplementary motor area (pre-SMA) can converts high level intention into sequential atomic actions, while SMA can integrate these atomic actions, current arm and attended object state into sensorimotor vector to apply corresponding torques on arm via pre-motor and primary motor of arm to achieve the intention. The high-level executive system contains PFC that does explicit inference and guide voluntary action based on language, while BG is the habitual action control center.

Using language makes human beings surpass animals in wisdom. To let machines understand, learn, and use language flexibly, we propose a human-like general language processing (HGLP) architecture, which contains sensorimotor, association, and cognitive systems. The HGLP network learns from easy to hard like a child, understands word meaning by coactivating multimodal neurons, comprehends and generates sentences by real-time constructing a virtual world model, and can express the whole thinking process verbally. HGLP rapidly learned 10+ different tasks including object recognition, sentence comprehension, imagination, attention control, query, inference, motion judgement, mixed arithmetic operation, digit tracing and writing, and human-like iterative thinking process guided by language. Language in the HGLP framework is not matching nor correlation statistics, but a script that can describe and control the imagination.