In MRI, deep neural networks have been proposed to reconstruct diffusion model parameters. However, the inputs of the networks were designed for a specific diffusion gradient scheme (i.e., diffusion gradient directions and numbers) and a specific b-value that are the same as the training data. In this study, a new deep neural network, referred to as DIFFnet, is developed to function as a generalized reconstruction tool of the diffusion-weighted signals for various gradient schemes and b-values. For generalization, diffusion signals are normalized in a q-space and then projected and quantized, producing a matrix (Qmatrix) as an input for the network. To demonstrate the validity of this approach, DIFFnet is evaluated for diffusion tensor imaging (DIFFnetDTI) and for neurite orientation dispersion and density imaging (DIFFnetNODDI). In each model, two datasets with different gradient schemes and b-values are tested. The results demonstrate accurate reconstruction of the diffusion parameters at substantially reduced processing time (approximately 8.7 times and 2240 times faster processing time than conventional methods in DTI and NODDI, respectively; less than 4% mean normalized root-mean-square errors (NRMSE) in DTI and less than 8% in NODDI). The generalization capability of the networks was further validated using reduced numbers of diffusion signals from the datasets. Different from previously proposed deep neural networks, DIFFnet does not require any specific gradient scheme and b-value for its input. As a result, it can be adopted as an online reconstruction tool for various complex diffusion imaging.

Recent progress in scientific machine learning (SciML) has opened up the possibility of training novel neural network architectures that solve complex partial differential equations (PDEs). Several (nearly data free) approaches have been recently reported that successfully solve PDEs, with examples including deep feed forward networks, generative networks, and deep encoder-decoder networks. However, practical adoption of these approaches is limited by the difficulty in training these models, especially to make predictions at large output resolutions ($\geq 1024 \times 1024$). Here we report on a software framework for data parallel distributed deep learning that resolves the twin challenges of training these large SciML models - training in reasonable time as well as distributing the storage requirements. Our framework provides several out of the box functionality including (a) loss integrity independent of number of processes, (b) synchronized batch normalization, and (c) distributed higher-order optimization methods. We show excellent scalability of this framework on both cloud as well as HPC clusters, and report on the interplay between bandwidth, network topology and bare metal vs cloud. We deploy this approach to train generative models of sizes hitherto not possible, showing that neural PDE solvers can be viably trained for practical applications. We also demonstrate that distributed higher-order optimization methods are $2-3\times$ faster than stochastic gradient-based methods and provide minimal convergence drift with higher batch-size.

Social recommendation has emerged to leverage social connections among users for predicting users' unknown preferences, which could alleviate the data sparsity issue in collaborative filtering based recommendation. Early approaches relied on utilizing each user's first-order social neighbors' interests for better user modeling, and failed to model the social influence diffusion process from the global social network structure. Recently, we propose a preliminary work of a neural influence diffusion network~(i.e., DiffNet) for social recommendation~(Diffnet), which models the recursive social diffusion process to capture the higher-order relationships for each user. However, we argue that, as users play a central role in both user-user social network and user-item interest network, only modeling the influence diffusion process in the social network would neglect the users' latent collaborative interests in the user-item interest network. In this paper, we propose DiffNet++, an improved algorithm of DiffNet that models the neural influence diffusion and interest diffusion in a unified framework. By reformulating the social recommendation as a heterogeneous graph with social network and interest network as input, DiffNet++ advances DiffNet by injecting these two network information for user embedding learning at the same time. This is achieved by iteratively aggregating each user's embedding from three aspects: the user's previous embedding, the influence aggregation of social neighbors from the social network, and the interest aggregation of item neighbors from the user-item interest network. Furthermore, we design a multi-level attention network that learns how to attentively aggregate user embeddings from these three aspects. Finally, extensive experimental results on two real-world datasets clearly show the effectiveness of our proposed model.