Abstract--Knee Osteoarthritis (KOA) is a musculoskeletal condition that can cause significant limitations and impairments in daily activities, especially among older individuals. T o evaluate the severity of KOA, typically, X-ray images of the affected knee are analyzed, and a grade is assigned based on the Kellgren-Lawrence (KL) grading system, which classifies KOA severity into five levels, ranging from 0 to 4. This approach requires a high level of expertise and time and is susceptible to subjective interpretation, thereby introducing potential diagnostic inaccuracies. T o address this problem a stacked ensemble model of fine-tuned Convolutional Neural Networks (CNNs) was developed for two classification tasks: a binary classifier for detecting the presence of KOA, and a multiclass classifier for precise grading across the KL spectrum. The proposed stacked ensemble model consists of a diverse set of pre-trained architectures, including MobileNetV2, Y ou Only Look Once (YOLOv8), and DenseNet201 as base learners and Categorical Boosting (CatBoost) as the meta-learner . This proposed model had a balanced test accuracy of 73% in multiclass classification and 87.5% in binary classification, which is higher than previous works in extant literature. Knee Osteoarthritis (KOA) [1] is a degenerative musculoskeletal joint disease in which the knee cartilage breaks down over time.

Early and accurate detection through Pap smear analysis is critical to improving patient outcomes and reducing mortality of Cervical cancer. State-of-the-art (SOTA) Convolutional Neural Networks (CNNs) require substantial computational resources, extended training time, and large datasets. In this study, a lightweight CNN model, S-Net (Simple Net), is developed specifically for cervical cancer detection and classification using Pap smear images to address these limitations. Alongside S-Net, six SOTA CNNs were evaluated using transfer learning, including multi-path (DenseNet201, ResNet152), depth-based (Serasnet152), width-based multi-connection (Xception), depth-wise separable convolutions (MobileNetV2), and spatial exploitation-based (VGG19). All models, including S-Net, achieved comparable accuracy, with S-Net reaching 99.99%. However, S-Net significantly outperforms the SOTA CNNs in terms of computational efficiency and inference time, making it a more practical choice for real-time and resource-constrained applications. A major limitation in CNN-based medical diagnosis remains the lack of transparency in the decision-making process. To address this, Explainable AI (XAI) techniques, such as SHAP, LIME, and Grad-CAM, were employed to visualize and interpret the key image regions influencing model predictions. The novelty of this study lies in the development of a highly accurate yet computationally lightweight model (S-Net) caPable of rapid inference while maintaining interpretability through XAI integration. Furthermore, this work analyzes the behavior of SOTA CNNs, investigates the effects of negative transfer learning on Pap smear images, and examines pixel intensity patterns in correctly and incorrectly classified samples.

The detection of brain tumor in MRI is an important aspect of ensuring timely diagnostics and treatment; however, manual analysis is commonly long and error-prone. Current approaches are not universal because they have limited generalization to heterogeneous tumors, are computationally inefficient, are not interpretable, and lack transparency, thus limiting trustworthiness. To overcome these issues, we introduce MobileDenseAttn, a fusion model of dual streams of MobileNetV2 and DenseNet201 that can help gradually improve the feature representation scale, computing efficiency, and visual explanations via GradCAM. Our model uses feature level fusion and is trained on an augmented dataset of 6,020 MRI scans representing glioma, meningioma, pituitary tumors, and normal samples. Measured under strict 5-fold cross-validation protocols, MobileDenseAttn provides a training accuracy of 99.75%, a testing accuracy of 98.35%, and a stable F1 score of 0.9835 (95% CI: 0.9743 to 0.9920). The extensive validation shows the stability of the model, and the comparative analysis proves that it is a great advancement over the baseline models (VGG19, DenseNet201, MobileNetV2) with a +3.67% accuracy increase and a 39.3% decrease in training time compared to VGG19. The GradCAM heatmaps clearly show tumor-affected areas, offering clinically significant localization and improving interpretability. These findings position MobileDenseAttn as an efficient, high performance, interpretable model with a high probability of becoming a clinically practical tool in identifying brain tumors in the real world.

Lung cancer (LC) ranks among the most frequently diagnosed cancers and is one of the most common causes of death for men and women worldwide. Computed Tomography (CT) images are the most preferred diagnosis method because of their low cost and their faster processing times. Many researchers have proposed various ways of identifying lung cancer using CT images. However, such techniques suffer from significant false positives, leading to low accuracy. The fundamental reason results from employing a small and imbalanced dataset. This paper introduces an innovative approach for LC detection and classification from CT images based on the DenseNet201 model. Our approach comprises several advanced methods such as Focal Loss, data augmentation, and regularization to overcome the imbalanced data issue and overfitting challenge. The findings show the appropriateness of the proposal, attaining a promising performance of 98.95% accuracy.

Hepatocellular carcinoma (HCC) ranks as the third leading cause of cancer-related mortality worldwide, with early detection being crucial for improving patient survival rates. However, early screening for HCC using ultrasound suffers from insufficient sensitivity and is highly dependent on the expertise of radiologists for interpretation. Leveraging the latest advancements in artificial intelligence (AI) in medical imaging, this study proposes an innovative Hierarchical Sparse Query Transformer (HSQformer) model that combines the strengths of Convolutional Neural Networks (CNNs) and Vision Transformers (ViTs) to enhance the accuracy of HCC diagnosis in ultrasound screening. The HSQformer leverages sparse latent space representations to capture hierarchical details at various granularities without the need for complex adjustments, and adopts a modular, plug-and-play design philosophy, ensuring the model's versatility and ease of use. The HSQformer's performance was rigorously tested across three distinct clinical scenarios: single-center, multi-center, and high-risk patient testing. In each of these settings, it consistently outperformed existing state-of-the-art models, such as ConvNext and SwinTransformer. Notably, the HSQformer even matched the diagnostic capabilities of senior radiologists and comprehensively surpassed those of junior radiologists. The experimental results from this study strongly demonstrate the effectiveness and clinical potential of AI-assisted tools in HCC screening. The full code is available at https://github.com/Asunatan/HSQformer.

The learner's ability to generate a hypothesis that closely approximates the target function is crucial in machine learning. Achieving this requires sufficient data; however, unauthorized access by an eavesdropping learner can lead to security risks. Thus, it is important to ensure the performance of the "authorized" learner by limiting the quality of the training data accessible to eavesdroppers. Unlike previous studies focusing on encryption or access controls, we provide a theorem to ensure superior learning outcomes exclusively for the authorized learner with quantum label encoding. In this context, we use the probably-approximately-correct (PAC) learning framework and introduce the concept of learning probability to quantitatively assess learner performance. Our theorem allows the condition that, given a training dataset, an authorized learner is guaranteed to achieve a certain quality of learning outcome, while eavesdroppers are not. Notably, this condition can be constructed based only on the authorized-learning-only measurable quantities of the training data, i.e., its size and noise degree. We validate our theoretical proofs and predictions through convolutional neural networks (CNNs) image classification learning.

Lymphoma diagnosis, particularly distinguishing between subtypes, is critical for effective treatment but remains challenging due to the subtle morphological differences in histopathological images. This study presents a novel hybrid deep learning framework that combines DenseNet201 for feature extraction with a Dense Neural Network (DNN) for classification, optimized using the Harris Hawks Optimization (HHO) algorithm. The model was trained on a dataset of 15,000 biopsy images, spanning three lymphoma subtypes: Chronic Lymphocytic Leukemia (CLL), Follicular Lymphoma (FL), and Mantle Cell Lymphoma (MCL). Our approach achieved a testing accuracy of 99.33\%, demonstrating significant improvements in both accuracy and model interpretability. Comprehensive evaluation using precision, recall, F1-score, and ROC-AUC underscores the model's robustness and potential for clinical adoption. This framework offers a scalable solution for improving diagnostic accuracy and efficiency in oncology.

Imaging techniques such as Chest X-rays, whole slide images, and optical coherence tomography serve as the initial screening and detection for a wide variety of medical pulmonary and ophthalmic conditions respectively. This paper investigates the intricacies of using pretrained deep convolutional neural networks with transfer learning across diverse medical imaging datasets with varying modalities for binary and multiclass classification. We conducted a comprehensive performance analysis with ten network architectures and model families each with pretraining and random initialization. Our finding showed that the use of pretrained models as fixed feature extractors yields poor performance irrespective of the datasets. Contrary, histopathology microscopy whole slide images have better performance. It is also found that deeper and more complex architectures did not necessarily result in the best performance. This observation implies that the improvements in ImageNet are not parallel to the medical imaging tasks. Within a medical domain, the performance of the network architectures varies within model families with shifts in datasets. This indicates that the performance of models within a specific modality may not be conclusive for another modality within the same domain. This study provides a deeper understanding of the applications of deep learning techniques in medical imaging and highlights the impact of pretrained networks across different medical imaging datasets under five different experimental settings.

Sugarcane, a key crop for the world's sugar industry, is prone to several diseases that have a substantial negative influence on both its yield and quality. To effectively manage and implement preventative initiatives, diseases must be detected promptly and accurately. In this study, we present a unique model called sugarcaneNet2024 that outperforms previous methods for automatically and quickly detecting sugarcane disease through leaf image processing. Our proposed model consolidates an optimized weighted average ensemble of seven customized and LASSO-regularized pre-trained models, particularly InceptionV3, InceptionResNetV2, DenseNet201, DenseNet169, Xception, and ResNet152V2. Initially, we added three more dense layers with 0.0001 LASSO regularization, three 30% dropout layers, and three batch normalizations with renorm enabled at the bottom of these pre-trained models to improve the performance. The accuracy of sugarcane leaf disease classification was greatly increased by this addition. Following this, several comparative studies between the average ensemble and individual models were carried out, indicating that the ensemble technique performed better. The average ensemble of all modified pre-trained models produced outstanding outcomes: 100%, 99%, 99%, and 99.45% for f1 score, precision, recall, and accuracy, respectively. Performance was further enhanced by the implementation of an optimized weighted average ensemble technique incorporated with grid search. This optimized sugarcaneNet2024 model performed the best for detecting sugarcane diseases, having achieved accuracy, precision, recall, and F1 score of 99.67%, 100%, 100%, and 100% , respectively.

One of the most serious corneal disorders, keratoconus is difficult to diagnose in its early stages and can result in blindness. This illness, which often appears in the second decade of life, affects people of all sexes and races. Convolutional neural networks (CNNs), one of the deep learning approaches, have recently come to light as particularly promising tools for the accurate and timely diagnosis of keratoconus. The purpose of this study was to evaluate how well different D-CNN models identified keratoconus-related diseases. To be more precise, we compared five different CNN-based deep learning architectures (DenseNet201, InceptionV3, MobileNetV2, VGG19, Xception). In our comprehensive experimental analysis, the DenseNet201-based model performed very well in keratoconus disease identification in our extensive experimental research. This model outperformed its D-CNN equivalents, with an astounding accuracy rate of 89.14% in three crucial classes: Keratoconus, Normal, and Suspect. The results demonstrate not only the stability and robustness of the model but also its practical usefulness in real-world applications for accurate and dependable keratoconus identification. In addition, D-CNN DenseNet201 performs extraordinarily well in terms of precision, recall rates, and F1 scores in addition to accuracy. These measures validate the model's usefulness as an effective diagnostic tool by highlighting its capacity to reliably detect instances of keratoconus and to reduce false positives and negatives.