Generalized Zero-Shot Learning (GZSL) targets recognizing new categories by learning transferable image representations. Existing methods find that, by aligning image representations with corresponding semantic labels, the semantic-aligned representations can be transferred to unseen categories. However, supervised by only seen category labels, the learned semantic knowledge is highly task-specific, which makes image representations biased towards seen categories. In this paper, we propose a novel Dual-Contrastive Embedding Network (DCEN) that simultaneously learns task-specific and task-independent knowledge via semantic alignment and instance discrimination. First, DCEN leverages task labels to cluster representations of the same semantic category by cross-modal contrastive learning and exploring semantic-visual complementarity. Besides task-specific knowledge, DCEN then introduces task-independent knowledge by attracting representations of different views of the same image and repelling representations of different images. Compared to high-level seen category supervision, this instance discrimination supervision encourages DCEN to capture low-level visual knowledge, which is less biased toward seen categories and alleviates the representation bias. Consequently, the task-specific and task-independent knowledge jointly make for transferable representations of DCEN, which obtains averaged 4.1% improvement on four public benchmarks.

A single gene can encode for different protein versions through a process called alternative splicing. Since proteins play major roles in cellular functions, aberrant splicing profiles can result in a variety of diseases, including cancers. Alternative splicing is determined by the gene's primary sequence and other regulatory factors such as RNA-binding protein levels. With these as input, we formulate the prediction of RNA splicing as a regression task and build a new training dataset (CAPD) to benchmark learned models. We propose discrete compositional energy network (DCEN) which leverages the hierarchical relationships between splice sites, junctions and transcripts to approach this task. In the case of alternative splicing prediction, DCEN models mRNA transcript probabilities through its constituent splice junctions' energy values. These transcript probabilities are subsequently mapped to relative abundance values of key nucleotides and trained with ground-truth experimental measurements. Through our experiments on CAPD, we show that DCEN outperforms baselines and ablation variants.