The Greenland Ice Sheet (GrIS) has emerged as a significant contributor to global sea level rise, primarily due to increased meltwater runoff. Supraglacial lakes, which form on the ice sheet surface during the summer months, can impact ice sheet dynamics and mass loss; thus, better understanding these lakes' seasonal evolution and dynamics is an important task. This study presents a computationally efficient time series classification approach that uses Gaussian Mixture Models (GMMs) of the Reconstructed Phase Spaces (RPSs) to identify supraglacial lakes based on their seasonal evolution: 1) those that refreeze at the end of the melt season, 2) those that drain during the melt season, and 3) those that become buried, remaining liquid insulated a few meters beneath the surface. Our approach uses time series data from the Sentinel-1 and Sentinel-2 satellites, which utilize microwave and visible radiation, respectively. Evaluated on a GrIS-wide dataset, the RPS-GMM model, trained on a single representative sample per class, achieves 85.46% accuracy with Sentinel-1 data alone and 89.70% with combined Sentinel-1 and Sentinel-2 data. This performance significantly surpasses existing machine learning and deep learning models which require a large training data. The results demonstrate the robustness of the RPS-GMM model in capturing the complex temporal dynamics of supraglacial lakes with minimal training data.

The three-dimensional structure of a protein plays a key role in determining its function. Methods like AlphaFold have revolutionized protein structure prediction based only on the amino-acid sequence. However, proteins often appear in multiple different conformations, and it is highly relevant to resolve the full conformational distribution. Single-particle cryo-electron microscopy (cryo EM) is a powerful tool for capturing a large number of images of a given protein, frequently in different conformations (referred to as particles). The images are, however, very noisy projections of the protein, and traditional methods for cryo EM reconstruction are limited to recovering a single, or a few, conformations. In this paper, we introduce cryoSPHERE, a deep learning method that takes as input a nominal protein structure, e.g. from AlphaFold, learns how to divide it into segments, and how to move these as approximately rigid bodies to fit the different conformations present in the cryo EM dataset. This formulation is shown to provide enough constraints to recover meaningful reconstructions of single protein structures. This is illustrated in three examples where we show consistent improvements over the current state-of-the-art for heterogeneous reconstruction.

Definition: The terms "robotics in snow and ice" refers to robotic systems being studied, developed, and used in areas where water can be found in its solid state. This specialized branch of field robotics investigates the impact of extreme conditions related to cold environments on autonomous vehicles.

In this post, we summarise the first two invited talks from the International Conference on Machine Learning (ICML). These presentations covered the fascinating topics of drug discovery, and the cryosphere. In Daphne's talk, she outlined some of the work she has been doing on transforming drug discovery using digital biology. To introduce the topic, Daphne described drug discovery as an interesting space that one can view as glass half-full or glass half-empty. The half-full version is demonstrated by the amazing advances in new medicines, such as vaccines, cell therapies, genetically targeted therapies, and cancer immunotherapies.