Introduction: Deep learning (DL) models can help detect intracranial aneurysms on CTA, but high false positive (FP) rates remain a barrier to clinical translation, despite improvement in model architectures and strategies like detection threshold tuning. We employed an automated, anatomy-based, heuristic-learning hybrid artery-vein segmentation post-processing method to further reduce FPs. Methods: Two DL models, CPM-Net and a deformable 3D convolutional neural network-transformer hybrid (3D-CNN-TR), were trained with 1,186 open-source CTAs (1,373 annotated aneurysms), and evaluated with 143 held-out private CTAs (218 annotated aneurysms). Brain, artery, vein, and cavernous venous sinus (CVS) segmentation masks were applied to remove possible FPs in the DL outputs that overlapped with: (1) brain mask; (2) vein mask; (3) vein more than artery masks; (4) brain plus vein mask; (5) brain plus vein more than artery masks. Results: CPM-Net yielded 139 true-positives (TP); 79 false-negative (FN); 126 FP. 3D-CNN-TR yielded 179 TP; 39 FN; 182 FP. FPs were commonly extracranial (CPM-Net 27.3%; 3D-CNN-TR 42.3%), venous (CPM-Net 56.3%; 3D-CNN-TR 29.1%), arterial (CPM-Net 11.9%; 3D-CNN-TR 53.3%), and non-vascular (CPM-Net 25.4%; 3D-CNN-TR 9.3%) structures. Method 5 performed best, reducing CPM-Net FP by 70.6% (89/126) and 3D-CNN-TR FP by 51.6% (94/182), without reducing TP, lowering the FP/case rate from 0.88 to 0.26 for CPM-NET, and from 1.27 to 0.62 for the 3D-CNN-TR. Conclusion: Anatomy-based, interpretable post-processing can improve DL-based aneurysm detection model performance. More broadly, automated, domain-informed, hybrid heuristic-learning processing holds promise for improving the performance and clinical acceptance of aneurysm detection models.

We present the Convex Polytope Machine (CPM), a novel non-linear learning algorithm for large-scale binary classification tasks. The CPM finds a large margin convex polytope separator which encloses one class. We develop a stochastic gradient descent based algorithm that is amenable to massive datasets, and augment it with a heuristic procedure to avoid sub-optimal local minima. Our experimental evaluations of the CPM on large-scale datasets from distinct domains (MNIST handwritten digit recognition, text topic, and web security) demonstrate that the CPM trains models faster, sometimes several orders of magnitude, than state-ofthe-art similar approaches and kernel-SVM methods while achieving comparable or better classification performance. Our empirical results suggest that, unlike prior similar approaches, we do not need to control the number of sub-classifiers (sides of the polytope) to avoid overfitting.

Single point supervised oriented object detection has gained attention and made initial progress within the community. SAM), PointOBB has shown promise due to its prior-free feature. In this paper, we propose PointOBBv2, a simpler, faster, and stronger method to generate pseudo rotated boxes from points without relying on any other prior. Specifically, we first generate a Class Probability Map (CPM) by training the network with non-uniform positive and negative sampling. We show that the CPM is able to learn the approximate object regions and their contours. Then, Principal Component Analysis (PCA) is applied to accurately estimate the orientation and the boundary of objects. By further incorporating a separation mechanism, we resolve the confusion caused by the overlapping on the CPM, enabling its operation in high-density scenarios. Extensive comparisons demonstrate that our method achieves a training speed 15.58 faster and an accuracy improvement of 11.60%/25.15%/21.19% on the DOTAv1.0/v1.5/v2.0 This significantly advances the cutting edge of single point supervised oriented detection in the modular track. Oriented object detection is essential for accurately labeling small and densely packed objects, especially in scenarios like remote sensing imagery, retail analysis, and scene text detection, where Oriented Bounding Boxes (OBBs) provide precise annotations.

High-resolution climate simulations are very valuable for understanding climate change impacts and planning adaptation measures. This has motivated use of regional climate models at sufficiently fine resolution to capture important small-scale atmospheric processes, such as convective storms. However, these regional models have very high computational costs, limiting their applicability. We present CPMGEM, a novel application of a generative machine learning model, a diffusion model, to skilfully emulate precipitation simulations from such a high-resolution model over England and Wales at much lower cost. This emulator enables stochastic generation of high-resolution (8.8km), daily-mean precipitation samples conditioned on coarse-resolution (60km) weather states from a global climate model. The output is fine enough for use in applications such as flood inundation modelling. The emulator produces precipitation predictions with realistic intensities and spatial structures and captures most of the 21st century climate change signal. We show evidence that the emulator has skill for extreme events up to and including 1-in-100 year intensities. Potential applications include producing high-resolution precipitation predictions for large-ensemble climate simulations and downscaling different climate models and climate change scenarios to better sample uncertainty in climate changes at local-scale.

Clinical prediction models are statistical or machine learning models used to quantify the risk of a certain health outcome using patient data. These can then inform potential interventions on patients, causing an effect called performative prediction: predictions inform interventions which influence the outcome they were trying to predict, leading to a potential underestimation of risk in some patients if a model is updated on this data. One suggested resolution to this is the use of hold-out sets, in which a set of patients do not receive model derived risk scores, such that a model can be safely retrained. We present an overview of clinical and research ethics regarding potential implementation of hold-out sets for clinical prediction models in health settings. We focus on the ethical principles of beneficence, non-maleficence, autonomy and justice. We also discuss informed consent, clinical equipoise, and truth-telling. We present illustrative cases of potential hold-out set implementations and discuss statistical issues arising from different hold-out set sampling methods. We also discuss differences between hold-out sets and randomised control trials, in terms of ethics and statistical issues. Finally, we give practical recommendations for researchers interested in the use hold-out sets for clinical prediction models.

Membership Inference Attacks have emerged as a dominant method for empirically measuring privacy leakage from machine learning models. Here, privacy is measured by the {\em{advantage}} or gap between a score or a function computed on the training and the test data. A major barrier to the practical deployment of these attacks is that they do not scale to large well-generalized models -- either the advantage is relatively low, or the attack involves training multiple models which is highly compute-intensive. In this work, inspired by discrepancy theory, we propose a new empirical privacy metric that is an upper bound on the advantage of a family of membership inference attacks. We show that this metric does not involve training multiple models, can be applied to large Imagenet classification models in-the-wild, and has higher advantage than existing metrics on models trained with more recent and sophisticated training recipes. Motivated by our empirical results, we also propose new membership inference attacks tailored to these training losses.

Compositionality provides appealing benefits in robotic manipulation, as it enables efficient learning, reasoning, and planning. Prior works have extensively studied the decomposition of scenes into objects and their relationships [1, 2, 3], as well as the division of long-horizon plans into primitive skills [3, 4], in order to navigate complex environments and devise long-horizon plans. In this paper, we present a different view of compositionality by considering object-part decomposition based on functionality (e.g., rim, handle, body), and leverage such decomposition to improve the learning of geometric and physical relationships for robot manipulation. In the context of language descriptions of objects, part names not only describe the geometric shapes of the parts but also capture their functional affordances. For instance, as depicted in Figure 1, for the action of "pouring", the rims define the boundary for alignment between the objects, the body of the pouring vessel should be tilted for the action, and its handle provides a constraint on the direction the object should face when pouring. Leveraging this knowledge of part affordances, we posit that a family of functional actions, such as pouring and constrained placing, can be conceptualized as a combination of functional correspondences between object parts.

Emotion understanding is a complex process that involves multiple components. The ability to recognise emotions not only leads to new context awareness methods but also enhances system interaction's effectiveness by perceiving and expressing emotions. Despite the attention to discrete and dimensional models, neuroscientific evidence supports those emotions as being complex and multi-faceted. One framework that resonated well with such findings is the Component Process Model (CPM), a theory that considers the complexity of emotions with five interconnected components: appraisal, expression, motivation, physiology and feeling. However, the relationship between CPM and discrete emotions has not yet been fully explored. Therefore, to better understand emotions underlying processes, we operationalised a data-driven approach using interactive Virtual Reality (VR) games and collected multimodal measures (self-reports, physiological and facial signals) from 39 participants. We used Machine Learning (ML) methods to identify the unique contributions of each component to emotion differentiation. Our results showed the role of different components in emotion differentiation, with the model including all components demonstrating the most significant contribution. Moreover, we found that at least five dimensions are needed to represent the variation of emotions in our dataset. These findings also have implications for using VR environments in emotion research and highlight the role of physiological signals in emotion recognition within such environments.

We present the Convex Polytope Machine (CPM), a novel non-linear learning algorithm for large-scale binary classification tasks. The CPM finds a large margin convex polytope separator which encloses one class. We develop a stochastic gradient descent based algorithm that is amenable to massive datasets, and augment it with a heuristic procedure to avoid sub-optimal local minima. Our experimental evaluations of the CPM on large-scale datasets from distinct domains (MNIST handwritten digit recognition, text topic, and web security) demonstrate that the CPM trains models faster, sometimes several orders of magnitude, than state-ofthe-art similar approaches and kernel-SVM methods while achieving comparable or better classification performance. Our empirical results suggest that, unlike prior similar approaches, we do not need to control the number of sub-classifiers (sides of the polytope) to avoid overfitting.