This paper proposes an eXplainable Artificial Intelligence (XAI)-driven methodology to enhance the understanding of cough sound analysis for respiratory disease management. We employ occlusion maps to highlight relevant spectral regions in cough spectrograms processed by a Convolutional Neural Network (CNN). Subsequently, spectral analysis of spectrograms weighted by these occlusion maps reveals significant differences between disease groups, particularly in patients with COPD, where cough patterns appear more variable in the identified spectral regions of interest. This contrasts with the lack of significant differences observed when analyzing raw spectrograms. The proposed approach extracts and analyzes several spectral features, demonstrating the potential of XAI techniques to uncover disease-specific acoustic signatures and improve the diagnostic capabilities of cough sound analysis by providing more interpretable results.

Indoor air quality plays an essential role in the safety and well-being of occupants, especially in the context of airborne diseases. This paper introduces AeroSafe, a novel approach aimed at enhancing the efficacy of indoor air purification systems through a robotic cough emulator testbed and a digital-twins-based aerosol residence time analysis. Current portable air filters often overlook the concentrations of respiratory aerosols generated by coughs, posing a risk, particularly in high-exposure environments like healthcare facilities and public spaces. To address this gap, we present a robotic dual-agent physical emulator comprising a maneuverable mannequin simulating cough events and a portable air purifier autonomously responding to aerosols. The generated data from this emulator trains a digital twins model, combining a physics-based compartment model with a machine learning approach, using Long Short-Term Memory (LSTM) networks and graph convolution layers. Experimental results demonstrate the model's ability to predict aerosol concentration dynamics with a mean residence time prediction error within 35 seconds. The proposed system's real-time intervention strategies outperform static air filter placement, showcasing its potential in mitigating airborne pathogen risks.

Chronic cough disorders are widespread and challenging to assess because they rely on subjective patient questionnaires about cough frequency. Wearable devices running Machine Learning (ML) algorithms are promising for quantifying daily coughs, providing clinicians with objective metrics to track symptoms and evaluate treatments. However, there is a mismatch between state-of-the-art metrics for cough counting algorithms and the information relevant to clinicians. Most works focus on distinguishing cough from non-cough samples, which does not directly provide clinically relevant outcomes such as the number of cough events or their temporal patterns. In addition, typical metrics such as specificity and accuracy can be biased by class imbalance. We propose using event-based evaluation metrics aligned with clinical guidelines on significant cough counting endpoints. We use an ML classifier to illustrate the shortcomings of traditional sample-based accuracy measurements, highlighting their variance due to dataset class imbalance and sample window length. We also present an open-source event-based evaluation framework to test algorithm performance in identifying cough events and rejecting false positives. We provide examples and best practice guidelines in event-based cough counting as a necessary first step to assess algorithm performance with clinical relevance.

Cough is a common symptom of respiratory and lung diseases. Cough detection is important to prevent, assess and control epidemic, such as COVID-19. This paper proposes a model to detect cough events from cough audio signals. The models are trained by the dataset combined ESC-50 dataset with self-recorded cough recordings. The test dataset contains inpatient cough recordings collected from inpatients of the respiratory disease department in Ruijin Hospital. We totally build 15 cough detection models based on different feature numbers selected by Random Frog, Uninformative Variable Elimination (UVE), and Variable influence on projection (VIP) algorithms respectively. The optimal model is based on 20 features selected from Mel Frequency Cepstral Coefficients (MFCC) features by UVE algorithm and classified with Support Vector Machine (SVM) linear two-class classifier. The best cough detection model realizes the accuracy, recall, precision and F1-score with 94.9%, 97.1%, 93.1% and 0.95 respectively. Its excellent performance with fewer dimensionality of the feature vector shows the potential of being applied to mobile devices, such as smartphones, thus making cough detection remote and non-contact.

5G is bringing new use cases to the forefront, one of the most prominent being machine learning empowered health care. Since respiratory infections are one of the notable modern medical concerns and coughs being a common symptom of this, a system for recognizing and diagnosing infections based on raw cough data would have a multitude of beneficial research and medical applications. In the literature, machine learning has been successfully used to detect cough events in controlled environments. In this work, we present a novel system that utilizes Convolutional Neural Networks (CNNs) to detect cough within environment audio and diagnose three potential illnesses (i.e., Bronchitis, Bronchiolitis, and Pertussis) based on their unique cough audio features. Our detection model achieves an accuracy of 90.17% and a specificity of 89.73%, whereas the diagnosis model achieves an accuracy of about 94.74% and an F1 score of 93.73%. These results clearly show that our system is successfully able to detect and separate cough events from background noise. Moreover, our single diagnosis model is capable of distinguishing between different illnesses without the need of separate models.