The rapid expansion of medical literature presents growing challenges for structuring and integrating domain knowledge at scale. Knowledge Graphs (KGs) offer a promising solution by enabling efficient retrieval, automated reasoning, and knowledge discovery. However, current KG construction methods often rely on supervised pipelines with limited generalizability or naively aggregate outputs from Large Language Models (LLMs), treating biomedical corpora as static and ignoring the temporal dynamics and contextual uncertainty of evolving knowledge. To address these limitations, we introduce MedKGent, a LLM agent framework for constructing temporally evolving medical KGs. Leveraging over 10 million PubMed abstracts published between 1975 and 2023, we simulate the emergence of biomedical knowledge via a fine-grained daily time series. MedKGent incrementally builds the KG in a day-by-day manner using two specialized agents powered by the Qwen2.5-32B-Instruct model. The Extractor Agent identifies knowledge triples and assigns confidence scores via sampling-based estimation, which are used to filter low-confidence extractions and inform downstream processing. The Constructor Agent incrementally integrates the retained triples into a temporally evolving graph, guided by confidence scores and timestamps to reinforce recurring knowledge and resolve conflicts. The resulting KG contains 156,275 entities and 2,971,384 relational triples. Quality assessments by two SOTA LLMs and three domain experts demonstrate an accuracy approaching 90%, with strong inter-rater agreement. To evaluate downstream utility, we conduct RAG across seven medical question answering benchmarks using five leading LLMs, consistently observing significant improvements over non-augmented baselines. Case studies further demonstrate the KG's value in literature-based drug repurposing via confidence-aware causal inference.

Given a set of objects in the visual field, how does the the visual system learn to attend to a particular object of interest while ignoring the rest? How are occlusions and background clutter so effortlessly discounted for when rec(cid:173) ognizing a familiar object? In this paper, we attempt to answer these ques(cid:173) tions in the context of a Kalman filter-based model of visual recognition that has previously proved useful in explaining certain neurophysiological phe(cid:173) nomena such as endstopping and related extra-classical receptive field ef(cid:173) fects in the visual cortex. By using results from the field of robust statistics, we describe an extension of the Kalman filter model that can handle multiple objects in the visual field. The resulting robust Kalman filter model demon(cid:173) strates how certain forms of attention can be viewed as an emergent prop(cid:173) erty of the interaction between top-down expectations and bottom-up sig(cid:173) nals.

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Given a set of objects in the visual field, how does the the visual system learn to attend to a particular object of interest while ignoring the rest? How are occlusions and background clutter so effortlessly discounted for when recognizing a familiar object? In this paper, we attempt to answer these questions in the context of a Kalman filter-based model of visual recognition that has previously proved useful in explaining certain neurophysiological phenomena such as endstopping and related extra-classical receptive field effects in the visual cortex. By using results from the field of robust statistics, we describe an extension of the Kalman filter model that can handle multiple objects in the visual field. The resulting robust Kalman filter model demonstrates how certain forms of attention can be viewed as an emergent property of the interaction between top-down expectations and bottom-up signals.

Given a set of objects in the visual field, how does the the visual system learn to attend to a particular object of interest while ignoring the rest? How are occlusions and background clutter so effortlessly discounted for when recognizing a familiar object? In this paper, we attempt to answer these questions in the context of a Kalman filter-based model of visual recognition that has previously proved useful in explaining certain neurophysiological phenomena such as endstopping and related extra-classical receptive field effects in the visual cortex. By using results from the field of robust statistics, we describe an extension of the Kalman filter model that can handle multiple objects in the visual field. The resulting robust Kalman filter model demonstrates how certain forms of attention can be viewed as an emergent property of the interaction between top-down expectations and bottom-up signals.