Federated Learning (FL) offers a promising approach for training clinical AI models without centralizing sensitive patient data. However, its real-world adoption is hindered by challenges related to privacy, resource constraints, and compliance. Existing Differential Privacy (DP) approaches often apply uniform noise, which disproportionately degrades model performance, even among well-compliant institutions. In this work, we propose a novel compliance-aware FL framework that enhances DP by adaptively adjusting noise based on quantifiable client compliance scores. Additionally, we introduce a compliance scoring tool based on key healthcare and security standards to promote secure, inclusive, and equitable participation across diverse clinical settings. Extensive experiments on public datasets demonstrate that integrating under-resourced, less compliant clinics with highly regulated institutions yields accuracy improvements of up to 15% over traditional FL. This work advances FL by balancing privacy, compliance, and performance, making it a viable solution for real-world clinical workflows in global healthcare.

Ensuring content compliance with community guidelines is crucial for maintaining healthy online social environments. However, traditional human-based compliance checking struggles with scaling due to the increasing volume of user-generated content and a limited number of moderators. Recent advancements in Natural Language Understanding demonstrated by Large Language Models unlock new opportunities for automated content compliance verification. This work evaluates six AI-agents built on Open-LLMs for automated rule compliance checking in Decentralized Social Networks, a challenging environment due to heterogeneous community scopes and rules. Analyzing over 50,000 posts from hundreds of Mastodon servers, we find that AI-agents effectively detect non-compliant content, grasp linguistic subtleties, and adapt to diverse community contexts. Most agents also show high inter-rater reliability and consistency in score justification and suggestions for compliance. Human-based evaluation with domain experts confirmed the agents' reliability and usefulness, rendering them promising tools for semi-automated or human-in-the-loop content moderation systems.

We introduce a framework for the use of large language models (LLMs) in Building Understandable Messaging for Policy and Evidence Review (BUMPER). LLMs are proving capable of providing interfaces for understanding and synthesizing large databases of diverse media. This presents an exciting opportunity to supercharge the translation of scientific evidence into policy and action, thereby improving livelihoods around the world. However, these models also pose challenges related to access, trust-worthiness, and accountability. The BUMPER framework is built atop a scientific knowledge base (e.g., documentation, code, survey data) by the same scientists (e.g., individual contributor, lab, consortium). We focus on a solution that builds trustworthiness through transparency, scope-limiting, explicit-checks, and uncertainty measures. LLMs are rapidly being adopted and consequences are poorly understood. The framework addresses open questions regarding the reliability of LLMs and their use in high-stakes applications. We provide a worked example in health policy for a model designed to inform measles control programs. We argue that this framework can facilitate accessibility of and confidence in scientific evidence for policymakers, drive a focus on policy-relevance and translatability for researchers, and ultimately increase and accelerate the impact of scientific knowledge used for policy decisions.

The EU AI Act is the proposed EU legislation concerning AI systems. This paper identifies several categories of the AI Act. Based on this categorization, a questionnaire is developed that serves as a tool to offer insights by creating quantitative data. Analysis of the data shows various challenges for organizations in different compliance categories. The influence of organization characteristics, such as size and sector, is examined to determine the impact on compliance. The paper will also share qualitative data on which questions were prevalent among respondents, both on the content of the AI Act as the application. The paper concludes by stating that there is still room for improvement in terms of compliance with the AIA and refers to a related project that examines a solution to help these organizations.

Objective: Errors of omission are a common cause of systems failures. Physicians often fail to order tests or treatments needed to monitor/ameliorate the effects of other tests or treatments. The authors hypothesized that automated, guideline-based reminders to physicians, provided as they wrote orders, could reduce these omissions. Design: The study was performed on the inpatient general medicine ward of a public teaching hospital. Faculty and housestaff from the Indiana University School of Medicine, who used computer workstations to write orders, were randomized to intervention and control groups. As intervention physicians wrote orders for 1 of 87 selected tests or treatments, the computer suggested corollary orders needed to detect or ameliorate adverse reactions to the trigger orders. The physicians could accept or reject these suggestions. Results: During the 6-month trial, reminders about corollary orders were presented to 48 intervention physicians and withheld from 41 control physicians. Intervention physicians ordered the suggested corollary orders in 46.3% of instances when they received a reminder, compared with 21.9% compliance by control physicians (p 0.0001). Physicians discriminated in their acceptance of suggested orders, readily accepting some while rejecting others. There were one third fewer interventions initiated by pharmacists with physicians in the intervention than control groups. Conclusion: This study demonstrates that physician workstations, linked to a comprehensive electronic medical record, can be an efficient means for decreasing errors of omissions and improving adherence to practice guidelines.