Intraoperative pathology is pivotal to precision surgery, yet its clinical impact is constrained by diagnostic complexity and the limited availability of high-quality frozen-section data. While computational pathology has made significant strides, the lack of large-scale, prospective validation has impeded its routine adoption in surgical workflows. Here, we introduce CRISP, a clinical-grade foundation model developed on over 100,000 frozen sections from eight medical centers, specifically designed to provide Clinical-grade Robust Intraoperative Support for Pathology (CRISP). CRISP was comprehensively evaluated on more than 15,000 intraoperative slides across nearly 100 retrospective diagnostic tasks, including benign-malignant discrimination, key intraoperative decision-making, and pan-cancer detection, etc. The model demonstrated robust generalization across diverse institutions, tumor types, and anatomical sites-including previously unseen sites and rare cancers. In a prospective cohort of over 2,000 patients, CRISP sustained high diagnostic accuracy under real-world conditions, directly informing surgical decisions in 92.6% of cases. Human-AI collaboration further reduced diagnostic workload by 35%, avoided 105 ancillary tests and enhanced detection of micrometastases with 87.5% accuracy. Together, these findings position CRISP as a clinical-grade paradigm for AI-driven intraoperative pathology, bridging computational advances with surgical precision and accelerating the translation of artificial intelligence into routine clinical practice.

Unlike in language or vision, one of the fundamental challenges in robot learning is the lack of access to vast data resources. We can further break down the problem into (1) data sparsity from the angle of data representation and (2) data scarcity from the angle of data quantity. In this thesis, I will discuss selected works on two domains: (1) tactile sensing and (2) rehabilitation robots, which are exemplars of data sparsity and scarcity, respectively. Tactile sensing is an essential modality for robotics, but tactile data are often sparse, and for each interaction with the physical world, tactile sensors can only obtain information about the local area of contact. I will discuss my work on learning vision-free tactile-only exploration and manipulation policies through model-free reinforcement learning to make efficient use of sparse tactile information. On the other hand, rehabilitation robots are an example of data scarcity to the extreme due to the significant challenge of collecting biosignals from disabled-bodied subjects at scale for training. I will discuss my work in collaboration with the medical school and clinicians on intent inferral for stroke survivors, where a hand orthosis developed in our lab collects a set of biosignals from the patient and uses them to infer the activity that the patient intends to perform, so the orthosis can provide the right type of physical assistance at the right moment. My work develops machine learning algorithms that enable intent inferral with minimal data, including semi-supervised, meta-learning, and generative AI methods.

This paper offers a comprehensive analysis of collaborative bandit algorithms and provides a thorough comparison of their performance. Collaborative bandits aim to improve the performance of contextual bandits by introducing relationships between arms (or items), allowing effective propagation of information. Collaboration among arms allows the feedback obtained through a single user (item) to be shared across related users (items). Introducing collaboration also alleviates the cold user (item) problem, i.e., lack of historical information when a new user (item) arriving to the platform with no prior record of interactions. In the context of modeling the relationships between arms (items), there are two main approaches: Hard and soft clustering. We call approaches that model the relationship between arms in an \textit{absolute} manner as hard clustering, i.e., the relationship is binary. Soft clustering relaxes membership constraints, allowing \textit{fuzzy} assignment. Focusing on the latter, we provide extensive experiments on the state-of-the-art collaborative contextual bandit algorithms and investigate the effect of sparsity and how the exploration intensity acts as a correction mechanism. Our numerical experiments demonstrate that controlling for sparsity in collaboration improves data efficiency and performance as it better informs learning. Meanwhile, increasing the exploration intensity acts as a correction because it effectively reduces variance due to potentially misspecified relationships among users. We observe that this misspecification is further remedied by introducing latent factors, and thus, increasing the dimensionality of the bandit parameters.

The problem of color clustering is defined and shown to be a problem of assigning a large number (hundreds of thousands) of 3-vectors to a small number (256) of clusters. Finding those clusters in such a way that they best represent a full color image using only 256 distinct colors is a burdensome computational problem. In this paper, the problem is solved using "classical" techniques -- k-means clustering, vector quantization (which turns out to be the same thing in this application), competitive learning, and Kohonen self-organizing feature maps. Quality of the result is judged subjectively by how much the pseudo-color result resembles the true color image, by RMS quantization error, and by run time. The Kohonen map provides the best solution.

We introduce in this paper a learning paradigm in which the training data is transformed by a diffeomorphic transformation before prediction. The learning algorithm minimizes a cost function evaluating the prediction error on the training set penalized by the distance between the diffeomorphism and the identity. The approach borrows ideas from shape analysis, in the way diffeomorphisms are estimated for shape and image alignment, and brings them in a previously unexplored setting, estimating, in particular diffeomorphisms in much larger dimensions.

Results highlight performance of Theano's current full release which does not support CuDNN 6 while all other frameworks do. I don't see how using half baked beta versions for benchmarking is the right way of running the tests. All frameworks can claim that their next beta version has better performance but they also have unresolved issues. Also CuDNN 7 is already available and if tests are run using beta versions, eventually some will support 7 versus Theano's beta support for CuDNN 6 causing the same issue. I hope you see the point I am trying to make.

"vector quantization", and "unsupervised learning" are all words which descn'be the same process: assigning a few exemplars to represent a large set of samples. Perfonning that process is the subject of a substantial body of literature. In this paper, we are concerned with the comparison of various clustering techniques to a particular, practical application: color clustering. The color clustering problem is as follows: an image is recorded in full color -- that is, three components, RED, GREEN, and BLUE, each of which has been measured to 8 bits of precision. Thus, each pixel is a 24 bit quantity. We must find a representation in which 2563 possible colors are represented by only 8 bits per pixel. That is, for a problem with 256000 variables (512 x 512) variables, assign each variable to one of only 256 classes. The color clustering problem is currently of major economic interest since millions of display systems are sold each year which can only store 8 bits per pixel, but on which users would like to be able to display "true" color (or at least as near true color as possible). In this study, we have approached the problem using the standard techniques from the literature (including k-means -- ISODATA clustering[1,3,61, LBG[4]), competitive learning (referred to as CL herein) [2], and Kohonen feature maps [5,7,9].

"vector quantization", and "unsupervised learning" are all words which descn'be the same process: assigning a few exemplars to represent a large set of samples. Perfonning that process is the subject of a substantial body of literature. In this paper, we are concerned with the comparison of various clustering techniques to a particular, practical application: color clustering. The color clustering problem is as follows: an image is recorded in full color -- that is, three components, RED, GREEN, and BLUE, each of which has been measured to 8 bits of precision. Thus, each pixel is a 24 bit quantity. We must find a representation in which 2563 possible colors are represented by only 8 bits per pixel. That is, for a problem with 256000 variables (512 x 512) variables, assign each variable to one of only 256 classes. The color clustering problem is currently of major economic interest since millions of display systems are sold each year which can only store 8 bits per pixel, but on which users would like to be able to display "true" color (or at least as near true color as possible). In this study, we have approached the problem using the standard techniques from the literature (including k-means -- ISODATA clustering[1,3,61, LBG[4]), competitive learning (referred to as CL herein) [2], and Kohonen feature maps [5,7,9].

Quality of the is judged subjectivelyby how much the pseudo-colorresultresult resemblesthe true color image, by RMS quantizationerror, and by run time.