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The scientist using AI to hunt for antibiotics just about everywhere
César de la Fuente is on a mission to combat antimicrobial resistance by looking at nature's own solutions. César de la Fuente is an associate professor at the University of Pennsylvania, where he leads the Machine Biology Group. When he was just a teenager trying to decide what to do with his life, César de la Fuente compiled a list of the world's biggest problems. He ranked them inversely by how much money governments were spending to solve them. Antimicrobial resistance topped the list. Twenty years on, the problem has not gone away.
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Is "Six Seven" Really Brain Rot?
Is "Six Seven" Really Brain Rot? The viral phrase is easy to dismiss, but its ubiquity suggests something crucial about human nature. Recently, my wife was texting with a friend who lives in Singapore. The news from the other side of the world turned out to be that kids there had discovered "six seven." On Halloween, our friend reported, a boy with a handmade "six seven" jersey had earned applause as he made his way through her neighborhood--a place that's a long way from Sixty-seventh Street in Philadelphia, which the rapper Skrilla may have been referencing in his song "Doot Doot (6 7)," which came out last December.
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The Onion Made an Absolutely Unhinged Jeffrey Epstein Mockumentary
In the current media landscape, it's a wonder it even got made. In a world where hallowed news organizations transform into conservative mouthpieces and milquetoast late-night jokes are grounds for suspension, satirical headlines from the Onion can feel closer to real life than parody. Now the site is taking on one of the most taboo subjects of all--disgraced sex offender and financier Jeffrey Epstein--in mockumentary form. It launches in theaters in New York City, Minneapolis, Los Angeles, and San Francisco for one day only on October 2; after that it will be available online. You can watch the trailer right here.
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Using generative AI, researchers design compounds that can kill drug-resistant bacteria
With help from artificial intelligence, MIT researchers have designed novel antibiotics that can combat two hard-to-treat infections: drug-resistant Neisseria gonorrhoeae and multi-drug-resistant Staphylococcus aureus (MRSA). Using generative AI algorithms, the research team designed more than 36 million possible compounds and computationally screened them for antimicrobial properties. The top candidates they discovered are structurally distinct from any existing antibiotics, and they appear to work by novel mechanisms that disrupt bacterial cell membranes. This approach allowed the researchers to generate and evaluate theoretical compounds that have never been seen before -- a strategy that they now hope to apply to identify and design compounds with activity against other species of bacteria. "We're excited about the new possibilities that this project opens up for antibiotics development. Our work shows the power of AI from a drug design standpoint, and enables us to exploit much larger chemical spaces that were previously inaccessible," says James Collins, the Termeer Professor of Medical Engineering and Science in MIT's Institute for Medical Engineering and Science (IMES) and Department of Biological Engineering, and a member of the Broad Institute.
Inside the Multimillion-Dollar Gray Market for Video Game Cheats
Software that can see opponents through walls. Aimbots that can lock onto other players automatically. Tools that can boost characters' stats to the max. The world of online game cheats is expansive--with some cheat websites advertising hacks for dozens of PC games--and it's being driven by an underground economy that's allegedly raking in millions every year. Over the last two years, a group of computer scientists has been analyzing and mapping the online cheat marketplace, observing what behaviors get people banned from games, and probing the effectiveness of anti-cheat systems created by games developers.
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Fears AI factcheckers on X could increase promotion of conspiracy theories
A decision by Elon Musk's X social media platform to enlist artificial intelligence chatbots to draft factchecks risks increasing the promotion of "lies and conspiracy theories", a former UK technology minister has warned. Damian Collins accused Musk's firm of "leaving it to bots to edit the news" after X announced on Tuesday that it would allow large language models to write community notes to clarify or correct contentious posts, before users approve them for publication. The notes have previously been written by humans. X said using AI to write factchecking notes – which sit beneath some X posts – "advances the state of the art in improving information quality on the internet". Keith Coleman, the vice-president of product at X, said humans would review AI-generated notes and the note would appear only if people with a variety of viewpoints found it useful.
4 Senate amendments to Trump megabill that failed -- and 1 that passed
Fox News' Chad Pergram reports the latest on the Senate's vote-a-rama from Capitol Hill. Many senators failed to get their amendments across the finish line during the chamber's vote-a-rama on Monday, leaving the future of President Donald Trump's "big, beautiful bill" uncertain. Two key failures came from Sen. Susan Collins, R-Maine, and Sen. John Cornyn, R-Texas, with the former proposing a plan that would have boosted funding for rural hospitals and the latter calling for further cuts to Medicaid. Collins and Cornyn were far from the only lawmakers who had amendments fail, however. Here are some details on some of the unsuccessful efforts, plus one that succeeded with nearly unanimous support.
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American tennis star Danielle Collins defends outburst toward cameraman during tournament
PongBot is an artificial intelligence-powered tennis robot. American tennis star Danielle Collins on Tuesday defended her outburst toward a cameraman during a tournament last week. Collins' incident occurred at the Internationaux de Strasbourg against Emma Raducanu. During a changeover, she told the cameraman to keep their distance as she refilled her water bottle. She said the cameraman was acting "wildly inappropriate."
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American tennis star Danielle Collins accuses cameraman of 'wildly inappropriate' behavior
PongBot is an artificial intelligence-powered tennis robot. American tennis player Danielle Collins had some choice words for the cameraman during her Internationaux de Strasbourg match against Emma Raducanu on Wednesday afternoon. Collins was in the middle of a changeover when she felt the cameraman's hovering was a bit too close for comfort in the middle of the third and defining set. She got off the bench and made the point clear. Danielle Collins celebrates during her match against Madison Keys in the third round of the women's singles at the 2025 Australian Open at Melbourne Park in Melbourne, Australia, on Jan. 18, 2025.