Given the large scale of public functional Magnetic Resonance Imaging (fMRI), e.g., UKBiobank (UKB) and Human Connectome Projects (HCP), brain foundation models are emerging. Although the amount of samples under rich environmental variables is unprecedented, existing brain foundation models learn from fMRI derived from a narrow range of cognitive states stimulated by similar environments, causing the limited robustness demonstrated in various applications and datasets acquired with different pipelines and limited sample size. By capitalizing on the variety of cognitive status as subjects performing explicit tasks, we present the mixture of brain experts, namely BrainMoE, pre-training on tasking fMRI with rich behavioral tasks in addition to resting fMRI for a robust brain foundation model. Brain experts are designed to produce embeddings for different behavioral tasks related to cognition. Afterward, these cognition embeddings are mixed by a cognition adapter via cross-attention so that BrainMoE can handle orthogonal embeddings and be robust on those boutique downstream datasets. We have pre-trained two existing self-regressive architectures and one new supervised architecture as brain experts on 68,251 fMRI scans among UKB and HCP, containing 12 different cognitive states. Then, BrainMoE is evaluated on a variety of applications, including sex, age prediction, human behavior recognition, disease early diagnosis of Autism, Parkinson's disease, Alzheimer's disease, and Schizophrenia, and fMRI-EEG multimodal applications, where promising results in eight datasets from three different pipelines indicate great potential to facilitate current neuroimaging applications in clinical routines.

A fundamental challenge in cognitive neuroscience is understanding how cognition emerges from the interplay between structural connectivity (SC) and dynamic functional connectivity (FC) in the brain. Network neuroscience has emerged as a powerful framework to understand brain function through a holistic perspective on structure-function relationships. In this context, current machine learning approaches typically seek to establish direct mappings between structural connectivity (SC) and functional connectivity (FC) associated with specific cognitive states. However, these state-independent methods often yield inconsistent results due to overlapping brain networks across cognitive states. To address this limitation, we conceptualize to uncover the dendritic coupling mechanism between one static SC and multiple FCs by solving a flow problem that bridges the distribution of SC to a mixed distribution of FCs, conditioned on various cognitive states, along a Riemannian manifold of symmetric positive-definite (SPD) manifold. We further prove the equivalence between flow matching on the SPD manifold and on the computationally efficient Cholesky manifold. Since a spare of functional connections is shared across cognitive states, we introduce the notion of consensus control to promote the shared kinetic structures between multiple FC-to-SC pathways via synchronized coordination, yielding a biologically meaningful underpinning on SC-FC coupling mechanism. Together, we present BrainFlow, a reversible generative model that achieves state-of-the-art performance on not only synthetic data but also large-scale neuroimaging datasets from UK Biobank and Human Connectome Project.

Given the large scale of public functional Magnetic Resonance Imaging (fMRI), e.g., UK Biobank (UKB) and Human Connectome Projects (HCP), brain foundation models are emerging. Although the amount of samples under rich environmental variables is unprecedented, existing brain foundation models learn from fMRI derived from a narrow range of cognitive states stimulated by similar environments, causing the limited robustness demonstrated in various applications and datasets acquired with different pipelines and limited sample size. By capitalizing on the variety of cognitive status as subjects performing explicit tasks, we present the mixture of brain experts, namely BrainMoE, pre-training on tasking fMRI with rich behavioral tasks in addition to resting fMRI for a robust brain foundation model. Brain experts are designed to produce embeddings for different behavioral tasks related to cognition. Afterward, these cognition embeddings are mixed by a cognition adapter via cross-attention so that BrainMoE can handle orthogonal embeddings and be robust on those boutique downstream datasets. We have pre-trained two existing self-regressive architectures and one new supervised architecture as brain experts on 68,251 fMRI scans among UKB and HCP, containing 12 different cognitive states. Then, BrainMoE is evaluated on a variety of applications, including sex, age prediction, human behavior recognition, disease early diagnosis of Autism, Parkinson's disease, Alzheimer's disease, and Schizophrenia, and fMRI-EEG multimodal applications, where promising results in eight datasets from three different pipelines indicate great potential to facilitate current neuroimaging applications in clinical routines.

Learners sharing similar implicit cognitive states often display comparable observable problem-solving performances. Leveraging collaborative connections among such similar learners proves valuable in comprehending human learning. Motivated by the success of collaborative modeling in various domains, such as recommender systems, we aim to investigate how collaborative signals among learners contribute to the diagnosis of human cognitive states (i.e., knowledge proficiency) in the context of intelligent education.The primary challenges lie in identifying implicit collaborative connections and disentangling the entangled cognitive factors of learners for improved explainability and controllability in learner Cognitive Diagnosis (CD). However, there has been no work on CD capable of simultaneously modeling collaborative and disentangled cognitive states. To address this gap, we present Coral, a $\underline{Co}$llabo$\underline{ra}$tive cognitive diagnosis model with disentang$\underline{l}$ed representation learning. Specifically, Coral first introduces a disentangled state encoder to achieve the initial disentanglement of learners' states.Subsequently, a meticulously designed collaborative representation learning procedure captures collaborative signals.

The growth of Massive Open Online Courses (MOOCs) presents significant challenges for personalized learning, where concept recommendation is crucial. Existing approaches typically rely on heterogeneous information networks or knowledge graphs to capture conceptual relationships, combined with knowledge tracing models to assess learners' cognitive states. However, these methods face significant limitations due to their dependence on high-quality structured knowledge graphs, which are often scarce in real-world educational scenarios. To address this fundamental challenge, this paper proposes CLLMRec, a novel framework that leverages Large Language Models through two synergistic technical pillars: Semantic Alignment and Prerequisite Knowledge Distillation. The Semantic Alignment component constructs a unified representation space by encoding unstructured textual descriptions of learners and concepts. The Prerequisite Knowledge Distillation paradigm employs a teacher-student architecture, where a large teacher LLM (implemented as the Prior Knowledge Aware Component) extracts conceptual prerequisite relationships from its internalized world knowledge and distills them into soft labels to train an efficient student ranker. Building upon these foundations, our framework incorporates a fine-ranking mechanism that explicitly models learners' real-time cognitive states through deep knowledge tracing, ensuring recommendations are both structurally sound and cognitively appropriate. Extensive experiments on two real-world MOOC datasets demonstrate that CLLMRec significantly outperforms existing baseline methods across multiple evaluation metrics, validating its effectiveness in generating truly cognitive-aware and personalized concept recommendations without relying on explicit structural priors.

Decoded Neurofeedback (DecNef) is a flourishing non-invasive approach to brain modulation with wide-ranging applications in neuromedicine and cognitive neuroscience. However, progress in DecNef research remains constrained by subject-dependent learning variability, reliance on indirect measures to quantify progress, and the high cost and time demands of experimentation. We present DecNefLab, a modular and interpretable simulation framework that formalizes DecNef as a machine learning problem. Beyond providing a virtual laboratory, DecNefLab enables researchers to model, analyze and understand neurofeedback dynamics. Using latent variable generative models as simulated participants, DecNefLab allows direct observation of internal cognitive states and systematic evaluation of how different protocol designs and subject characteristics influence learning. We demonstrate how this approach can (i) reproduce empirical phenomena of DecNef learning, (ii) identify conditions under which DecNef feedback fails to induce learning, and (iii) guide the design of more robust and reliable DecNef protocols in silico before human implementation. In summary, DecNefLab bridges computational modeling and cognitive neuroscience, offering a principled foundation for methodological innovation, robust protocol design, and ultimately, a deeper understanding of DecNef-based brain modulation.

Abstract--Large Language Models (LLMs) have transformed code auto-completion by generating context-aware suggestions. Y et, deciding when to present these suggestions remains under-explored, often leading to interruptions or wasted inference calls. We propose an adaptive timing mechanism that dynamically adjusts the delay before offering a suggestion based on real-time developer feedback. Our suggested method combines a logistic transform of recent acceptance rates with a bounded delay range, anchored by a high-level binary prediction of the developer's cognitive state. In a two-month deployment with professional developers, our system improved suggestion acceptance from 4.9% with no delay to 15.4% with static delays, and to 18.6% with adaptive timing--while reducing blind rejections (rejections without being read) from 8.3% to 0.36%. T ogether, these improvements increase acceptance and substantially reduce wasted inference calls by 75%, making LLM-based code assistants more efficient and cost-effective in practice. Modern software development increasingly relies on AIpowered code assistants--most prominently LLM-based tools such as GitHub Copilot--which leverage massive pre-trained models to suggest context-aware completions and entire code snippets [1], [2]. These systems aim to boost productivity by reducing boilerplate and aiding API recall. Subsequent work on specialized code models (e.g., CodeBERT and CodeT5) has further improved completion accuracy and relevance [3]-[5]. Despite advances in what content to generate, the timing of suggestion delivery remains an underexplored yet critical factor.

Brain-computer interfaces (BCIs) often suffer from limited robustness and poor long-term adaptability. Model performance rapidly degrades when user attention fluctuates, brain states shift over time, or irregular artifacts appear during interaction. To mitigate these issues, we introduce a user state-aware electroencephalogram (EEG) filtering framework that refines neural representations before decoding user intentions. The proposed method continuously estimates the user's cognitive state (e.g., focus or distraction) from EEG features and filters unreliable segments by applying adaptive weighting based on the estimated attention level. This filtering stage suppresses noisy or out-of-focus epochs, thereby reducing distributional drift and improving the consistency of subsequent decoding. Experiments on multiple EEG datasets that emulate real BCI scenarios demonstrate that the proposed state-aware filtering enhances classification accuracy and stability across different user states and sessions compared with conventional preprocessing pipelines. These findings highlight that leveraging brain-derived state information--even without additional user labels--can substantially improve the reliability of practical EEG-based BCIs.

Large language models (LLMs) face persistent challenges when handling long-context tasks, most notably the lost in the middle issue, where information located in the middle of a long input tends to be underutilized. Some existing methods that reduce input have the risk of discarding key information, while others that extend context windows often lead to attention dispersion. To address these limitations, we propose Tree of Agents (TOA), a multi-agent reasoning framework that segments the input into chunks processed by independent agents. Each agent generates its local cognition, then agents dynamically exchange information for collaborative reasoning along tree-structured paths. TOA enables agents to probe different reasoning orders for multi-perspective understanding, effectively mitigating position bias and reducing hallucinations. To improve processing efficiency, we incorporate prefix-hash caching and adaptive pruning strategies, achieving significant performance improvements with comparable API overhead. Experiments show that TOA, powered by compact LLaMA3.1-8B, significantly outperforms multiple baselines and demonstrates comparable performance to the latest and much larger commercial models, such as Gemini1.5-pro, on various long-context tasks. Code is available at https://github.com/Aireduce952/Tree-of-Agents.

While cognitive diagnosis (CD) effectively assesses students' knowledge mastery from structured test data, applying it to real-world teacher-student dialogues presents two fundamental challenges. Traditional CD models lack a suitable framework for handling dynamic, unstructured dialogues, and it's difficult to accurately extract diagnostic semantics from lengthy dialogues. To overcome these hurdles, we propose DiaCDM, an innovative model. We've adapted the initiation-response-evaluation (IRE) framework from educational theory to design a diagnostic framework tailored for dialogue. We also developed a unique graph-based encoding method that integrates teacher questions with relevant knowledge components to capture key information more precisely. To our knowledge, this is the first exploration of cognitive diagnosis in a dialogue setting. Experiments on three real-world dialogue datasets confirm that DiaCDM not only significantly improves diagnostic accuracy but also enhances the results' interpretability, providing teachers with a powerful tool for assessing students' cognitive states. The code is available at https://github.com/Mind-Lab-ECNU/DiaCDM/tree/main.