Vertical-domain large language models (LLMs) play a crucial role in specialized scenarios such as finance, healthcare, and law; however, their training often relies on large-scale annotated data and substantial computational resources, impeding rapid development and continuous iteration. To address these challenges, we introduce the Collaborative Editable Model (CoEM), which constructs a candidate knowledge pool from user-contributed domain snippets, leverages interactive user-model dialogues combined with user ratings and attribution analysis to pinpoint high-value knowledge fragments, and injects these fragments via in-context prompts for lightweight domain adaptation. With high-value knowledge, the LLM can generate more accurate and domain-specific content. In a financial information scenario, we collect 15k feedback from about 120 users and validate CoEM with user ratings to assess the quality of generated insights, demonstrating significant improvements in domain-specific generation while avoiding the time and compute overhead of traditional fine-tuning workflows.

Metacells are disjoint and homogeneous groups of single-cell profiles, representing discrete and highly granular cell states. Existing metacell algorithms tend to use only one modality to infer metacells, even though single-cell multi-omics datasets profile multiple molecular modalities within the same cell. Here, we present \textbf{C}ross-M\textbf{O}dal \textbf{E}mbedding for \textbf{M}etaCell Identification (COEM), which utilizes an embedded space leveraging the information of both scATAC-seq and scRNA-seq to perform aggregation, balancing the trade-off between fine resolution and sufficient sequencing coverage. COEM outperforms the state-of-the-art method SEACells by efficiently identifying accurate and well-separated metacells across datasets with continuous and discrete cell types. Furthermore, COEM significantly improves peak-to-gene association analyses, and facilitates complex gene regulatory inference tasks.