Many clinical risk scores are deployed as additive rules with nonnegative integer points assigned to relevant binary predictive features. These integer weights not only make the score easier to use in practice but also promote sparsity in the resulting prediction model. Such risk scores are often derived by first fitting a regression model and then rounding the estimated coefficients to the nearest integer after appropriate scaling. This approach is computationally fast but does not guarantee optimality of the resulting score. Alternatively, one may search over all possible integer weights to directly optimize a value function by posing the problem as an integer programming task. However, the associated computational burden can be substantial, especially when the value function is nonconcave or even discontinuous. In this paper, we develop new machine learning algorithms that employ a flexible greedy optimization strategy to learn such additive scoring directly under explicit and sensible optimality objectives. We apply the proposed method to a large electronic health record (EHR) cohort in Epic Cosmos to construct an integer-weighted comorbidity score for measuring the risk of post-discharge mortality. We also conduct a simulation study to examine the finite-sample operating characteristics.

Many machine learning systems make constrained decisions by optimizing factorized objectives, but the context-specific objective is often treated as fixed. We study contextual decision-weight learning: from logged decisions and proxy outputs, learn an optimizer-facing weight vector w(x) over interpretable decision factors z(x,d), rather than a direct policy or generic predictive score. We propose OTSS, an output-targeted soft-segmentation model that deploys the personalized decision-ready weight vector. At the function-class level, the theory highlights a hard-versus-soft distinction. Hard partitions incur an approximation-estimation tradeoff under overlap, while a realizable fixed-K soft class removes the hard-partition approximation floor and attains a parametric rate. We evaluate OTSS in controlled benchmarks with finite evaluation libraries, where the true weight vector and downstream regret can be computed exactly. In the representative overlap setting, OTSS attains the lowest mean regret among the comparators, including EM mixture regression, the strongest soft-mixture baseline in our comparison; it matches EM on coefficient recovery while running about two orders of magnitude faster. In a matched K=5 benchmark, OTSS remains competitive under hard-routed truth and improves as heterogeneity becomes softer and sample size grows. On a fixed Complete Journey retail anchor with real household covariates and action geometry, OTSS again achieves the lowest mean-regret point estimate.

The Rashomon set is the set of models that are approximately as good as the best model in the class. That is, it is the set of all good models.

We propose a federated learning framework for the calibration of parametric insurance indices under heterogeneous renewable energy production losses. Producers locally model their losses using Tweedie generalized linear models and private data, while a common index is learned through federated optimization without sharing raw observations. The approach accommodates heterogeneity in variance and link functions and directly minimizes a global deviance objective in a distributed setting. We implement and compare FedAvg, FedProx and FedOpt, and benchmark them against an existing approximation-based aggregation method. An empirical application to solar power production in Germany shows that federated learning recovers comparable index coefficients under moderate heterogeneity, while providing a more general and scalable framework.

Contextual linear optimization (CLO) uses predictive contextual features to reduce uncertainty in random cost coefficients and thereby improve average-cost performance. An example is the stochastic shortest path problem with random edge costs (e.g., traffic) and contextual features (e.g., lagged traffic, weather). Existing work on CLO assumes the data has fully observed cost coefficient vectors, but in many applications, we can only see the realized cost of a historical decision, that is, just one projection of the random cost coefficient vector, to which we refer as bandit feedback. We study a class of offline learning algorithms for CLO with bandit feedback, which we term induced empirical risk minimization (IERM), where we fit a predictive model to directly optimize the downstream performance of the policy it induces. We show a fast-rate regret bound for IERM that allows for misspecified model classes and flexible choices of the optimization estimate, and we develop computationally tractable surrogate losses. A byproduct of our theory of independent interest is fast-rate regret bound for IERM with full feedback and misspecified policy class. We compare the performance of different modeling choices numerically using a stochastic shortest path example and provide practical insights from the empirical results.

Time series autoregression (AR) is a classical tool for modeling auto-correlations and periodic structures in real-world systems. We revisit this model from an interpretable machine learning perspective by introducing sparse autoregression (SAR), where $\ell_0$-norm constraints are used to isolate dominant periodicities. We formulate exact mixed-integer optimization (MIO) approaches for both stationary and non-stationary settings and introduce two scalable extensions: a decision variable pruning (DVP) strategy for temporally-varying SAR (TV-SAR), and a two-stage optimization scheme for spatially- and temporally-varying SAR (STV-SAR). These models enable scalable inference on real-world spatiotemporal datasets. We validate our framework on large-scale mobility and climate time series. On NYC ridesharing data, TV-SAR reveals interpretable daily and weekly cycles as well as long-term shifts due to COVID-19. On climate datasets, STV-SAR uncovers the evolving spatial structure of temperature and precipitation seasonality across four decades in North America and detects global sea surface temperature dynamics, including El Niño. Together, our results demonstrate the interpretability, flexibility, and scalability of sparse autoregression for periodicity quantification in complex time series.

Contextual linear optimization (CLO) uses predictive contextual features to reduce uncertainty in random cost coefficients and thereby improve average-cost performance. An example is the stochastic shortest path problem with random edge costs (e.g., traffic) and contextual features (e.g., lagged traffic, weather). Existing work on CLO assumes the data has fully observed cost coefficient vectors, but in many applications, we can only see the realized cost of a historical decision, that is, just one projection of the random cost coefficient vector, to which we refer as bandit feedback. We study a class of offline learning algorithms for CLO with bandit feedback, which we term induced empirical risk minimization (IERM), where we fit a predictive model to directly optimize the downstream performance of the policy it induces. We show a fast-rate regret bound for IERM that allows for misspecified model classes and flexible choices of the optimization estimate, and we develop computationally tractable surrogate losses.