Last Tuesday, shortly after the Centers for Disease Control and Prevention issued relaxed guidelines for wearing masks in public during the COVID-19 pandemic, President Joe Biden gave a speech on the North Lawn of the White House. The setting was so verdant--bright sunlight, tall trees framing a lectern, shrubbery in full bloom--that it might have been a virtual Zoom background. Biden wore a black mask to the lectern, then took it off to speak. "If you're in a crowd, like in a stadium or at a concert, you still need to wear a mask, even if you're outside," he said. "But, beginning today, gathering with a group of friends in the park, going for a picnic, as long as you are vaccinated and outdoors, you can do it without a mask."

Human genes are not continuous but rather consist of short coding regions (exons) interspersed with highly variable non-coding regions (introns). We apply HMMs to the problem of modeling exons, introns and detecting splice sites in the human genome. Our most interesting result so far is the detection of particular oscillatory patterns, with a minimal period ofroughly 10 nucleotides, that seem to be characteristic of exon regions and may have significant biological implications.

Human genes are not continuous but rather consist of short coding regions (exons) interspersed with highly variable non-coding regions (introns). We apply HMMs to the problem of modeling exons, introns and detecting splice sites in the human genome. Our most interesting result so far is the detection of particular oscillatory patterns, with a minimal period ofroughly 10 nucleotides, that seem to be characteristic of exon regions and may have significant biological implications.

We apply HMMs to the problem of modeling exons, intronsand detecting splice sites in the human genome. Our most interesting result so far is the detection of particular oscillatory patterns,with a minimal period ofroughly 10 nucleotides, that seem to be characteristic of exon regions and may have significant biological implications.

Hidden Markov Models (HMMs) can be applied to several important problems in molecular biology. We introduce a new convergent learning algorithm for HMMs that, unlike the classical Baum-Welch algorithm is smooth and can be applied online or in batch mode, with or without the usual Viterbi most likely path approximation. Left-right HMMs with insertion and deletion states are then trained to represent several protein families including immunoglobulins and kinases. In all cases, the models derived capture all the important statistical properties of the families and can be used efficiently in a number of important tasks such as multiple alignment, motif detection, and classification.

Hidden Markov Models (HMMs) can be applied to several important problems in molecular biology. We introduce a new convergent learning algorithm for HMMs that, unlike the classical Baum-Welch algorithm is smooth and can be applied online or in batch mode, with or without the usual Viterbi most likely path approximation. Left-right HMMs with insertion and deletion states are then trained to represent several protein families including immunoglobulins and kinases. In all cases, the models derived capture all the important statistical properties of the families and can be used efficiently in a number of important tasks such as multiple alignment, motif detection, and classification.

Hidden Markov Models (HMMs) can be applied to several important problemsin molecular biology. We introduce a new convergent learning algorithm for HMMs that, unlike the classical Baum-Welch algorithm is smooth and can be applied online or in batch mode, with or without the usual Viterbi most likely path approximation. Left-right HMMs with insertion and deletion states are then trained to represent several protein families including immunoglobulins and kinases. In all cases, the models derived capture all the important statistical properties of the families and can be used efficiently in a number of important tasks such as multiple alignment, motif detection, andclassification.

Recent progress in network design demonstrates that nonlinear feedforward neural networks can perform impressive pattern classification for a variety of real-world applications (e.g., Le Cun et al., 1990; Waibel et al., 1989). Various simulations and relationships between the neural network and machine learning theoretical literatures also suggest that too large a number of free parameters ("weight overfitting") could substantially reduce generalization performance.

Recent progress in network design demonstrates that nonlinear feedforward neural networks can perform impressive pattern classification for a variety of real-world applications (e.g., Le Cun et al., 1990; Waibel et al., 1989). Various simulations and relationships between the neural network and machine learning theoretical literatures also suggest that too large a number of free parameters ("weight overfitting") could substantially reduce generalization performance.

Recent progress in network design demonstrates that nonlinear feedforward neural networkscan perform impressive pattern classification for a variety of real-world applications (e.g., Le Cun et al., 1990; Waibel et al., 1989). Various simulations and relationships between the neural network and machine learning theoretical literatures alsosuggest that too large a number of free parameters ("weight overfitting") could substantially reduce generalization performance.