Current methods for searching brain MR images rely on text-based approaches, highlighting a significant need for content-based image retrieval (CBIR) systems. Directly applying 3D brain MR images to machine learning models offers the benefit of effectively learning the brain's structure; however, building the generalized model necessitates a large amount of training data. While models that consider depth direction and utilize continuous 2D slices have demonstrated success in segmentation and classification tasks involving 3D data, concerns remain. Specifically, using general 2D slices may lead to the oversight of pathological features and discontinuities in depth direction information. Furthermore, to the best of the authors' knowledge, there have been no attempts to develop a practical CBIR system that preserves the entire brain's structural information. In this study, we propose an interpretable CBIR method for brain MR images, named iCBIR-Sli (Interpretable CBIR with 2D Slice Embedding), which, for the first time globally, utilizes a series of 2D slices. iCBIR-Sli addresses the challenges associated with using 2D slices by effectively aggregating slice information, thereby achieving low-dimensional representations with high completeness, usability, robustness, and interoperability, which are qualities essential for effective CBIR. In retrieval evaluation experiments utilizing five publicly available brain MR datasets (ADNI2/3, OASIS3/4, AIBL) for Alzheimer's disease and cognitively normal, iCBIR-Sli demonstrated top-1 retrieval performance (macro F1 = 0.859), comparable to existing deep learning models explicitly designed for classification, without the need for an external classifier. Additionally, the method provided high interpretability by clearly identifying the brain regions indicative of the searched-for disease.

Content-based image retrieval (CBIR) systems are an emerging technology that supports reading and interpreting medical images. Since 3D brain MR images are high dimensional, dimensionality reduction is necessary for CBIR using machine learning techniques. In addition, for a reliable CBIR system, each dimension in the resulting low-dimensional representation must be associated with a neurologically interpretable region. We propose a localized variational autoencoder (Loc-VAE) that provides neuroanatomically interpretable low-dimensional representation from 3D brain MR images for clinical CBIR. Loc-VAE is based on $\beta$-VAE with the additional constraint that each dimension of the low-dimensional representation corresponds to a local region of the brain. The proposed Loc-VAE is capable of acquiring representation that preserves disease features and is highly localized, even under high-dimensional compression ratios (4096:1). The low-dimensional representation obtained by Loc-VAE improved the locality measure of each dimension by 4.61 points compared to naive $\beta$-VAE, while maintaining comparable brain reconstruction capability and information about the diagnosis of Alzheimer's disease.

Deep learning-based approaches for content-based image retrieval (CBIR) of CT liver images is an active field of research, but suffers from some critical limitations. First, they are heavily reliant on labeled data, which can be challenging and costly to acquire. Second, they lack transparency and explainability, which limits the trustworthiness of deep CBIR systems. We address these limitations by (1) proposing a self-supervised learning framework that incorporates domain-knowledge into the training procedure and (2) providing the first representation learning explainability analysis in the context of CBIR of CT liver images. Results demonstrate improved performance compared to the standard self-supervised approach across several metrics, as well as improved generalisation across datasets. Further, we conduct the first representation learning explainability analysis in the context of CBIR, which reveals new insights into the feature extraction process. Lastly, we perform a case study with cross-examination CBIR that demonstrates the usability of our proposed framework. We believe that our proposed framework could play a vital role in creating trustworthy deep CBIR systems that can successfully take advantage of unlabeled data.

A major challenge in Content-Based Image Retrieval (CBIR) is to bridge the semantic gap between low-level image contents and high-level semantic concepts. Although researchers have investigated a variety of retrieval techniques using different types of features and distance functions, no single best retrieval solution can fully tackle this challenge. In a real-world CBIR task, it is often highly desired to combine multiple types of different feature representations and diverse distance measures in order to close the semantic gap. In this paper, we investigate a new framework of learning to rank for CBIR, which aims to seek the optimal combination of different retrieval schemes by learning from large-scale training data in CBIR. We first formulate the problem formally as a learning to rank task, which can be solved in general by applying the existing batch learning to rank algorithms from text information retrieval (IR). To further address the scalability towards large-scale online CBIR applications, we present a family of online learning to rank algorithms, which are significantly more efficient and scalable than classical batch algorithms for large-scale online CBIR. Finally, we conduct an extensive set of experiments, in which encouraging results show that our technique is effective, scalable and promising for large-scale CBIR.

Relevance Feedback in Content-Based Image Retrieval is a method where the feedback of the performance is being used to improve itself. Prior works use feature re-weighting and classification techniques as the Relevance Feedback methods. This paper shows a novel addition to the prior methods to further improve the retrieval accuracy. In addition to all of these, the paper also shows a novel idea to even improve the 0-th iteration retrieval accuracy from the information of Relevance Feedback.

A major challenge in Content-Based Image Retrieval (CBIR) is to bridge the semantic gap between low-level image contents and high-level semantic concepts. Although researchers have investigated a variety of retrieval techniques using different types of features and distance functions, no single best retrieval solution can fully tackle this challenge. In a real-world CBIR task, it is often highly desired to combine multiple types of different feature representations and diverse distance measures in order to close the semantic gap. In this paper, we investigate a new framework of learning to rank for CBIR, which aims to seek the optimal combination of different retrieval schemes by learning from large-scale training data in CBIR. We first formulate the problem formally as a learning to rank task, which can be solved in general by applying the existing batch learning to rank algorithms from text information retrieval (IR). To further address the scalability towards large-scale online CBIR applications, we present a family of online learning to rank algorithms, which are significantly more efficient and scalable than classical batch algorithms for large-scale online CBIR. Finally, we conduct an extensive set of experiments, in which encouraging results show that our technique is effective, scalable and promising for large-scale CBIR.