Surgical decision-making is complex and requires understanding causal relationships between patient characteristics, interventions, and outcomes. In high-stakes settings like spinal fusion or scoliosis correction, accurate estimation of individualized treatment effects (ITEs) remains limited due to the reliance on traditional statistical methods that struggle with complex, heterogeneous data. In this study, we develop a multi-task meta-learning framework, X-MultiTask, for ITE estimation that models each surgical decision (e.g., anterior vs. posterior approach, surgery vs. no surgery) as a distinct task while learning shared representations across tasks. To strengthen causal validity, we incorporate the inverse probability weighting (IPW) into the training objective. We evaluate our approach on two datasets: (1) a public spinal fusion dataset (1,017 patients) to assess the effect of anterior vs. posterior approaches on complication severity; and (2) a private AIS dataset (368 patients) to analyze the impact of posterior spinal fusion (PSF) vs. non-surgical management on patient-reported outcomes (PROs). Our model achieves the highest average AUC (0.84) in the anterior group and maintains competitive performance in the posterior group (0.77). It outperforms baselines in treatment effect estimation with the lowest overall $ε_{\text{NN-PEHE}}$ (0.2778) and $ε_{\text{ATE}}$ (0.0763). Similarly, when predicting PROs in AIS, X-MultiTask consistently shows superior performance across all domains, with $ε_{\text{NN-PEHE}}$ = 0.2551 and $ε_{\text{ATE}}$ = 0.0902. By providing robust, patient-specific causal estimates, X-MultiTask offers a powerful tool to advance personalized surgical care and improve patient outcomes. The code is available at https://github.com/Wizaaard/X-MultiTask.

This paper introduces the OPIAID algorithm, a novel approach for predicting and recommending personalized opioid dosages for individual patients. The algorithm optimizes pain management while minimizing opioid related adverse events (ORADE) by employing machine learning models trained on observational electronic health records (EHR) data. It leverages a causal machine learning approach to understand the relationship between opioid dose, case specific patient and intraoperative characteristics, and pain versus ORADE outcomes. The OPIAID algorithm considers patient-specific characteristics and the influence of different opiates, enabling personalized dose recommendations. This paper outlines the algorithm's methodology and architecture, and discusses key assumptions, and approaches to evaluating its performance.

The penultimate goal for developing machine learning models in supply chain management is to make optimal interventions. However, most machine learning models identify correlations in data rather than inferring causation, making it difficult to systematically plan for better outcomes. In this article, we propose and evaluate the use of causal machine learning for developing supply chain risk intervention models, and demonstrate its use with a case study in supply chain risk management in the maritime engineering sector. Our findings highlight that causal machine learning enhances decision-making processes by identifying changes that can be achieved under different supply chain interventions, allowing "what-if" scenario planning. We therefore propose different machine learning developmental pathways for for predicting risk, and planning for interventions to minimise risk and outline key steps for supply chain researchers to explore causal machine learning.

Automated decision-making (ADM) systems are being deployed across a diverse range of critical problem areas such as social welfare and healthcare. Recent work highlights the importance of causal ML models in ADM systems, but implementing them in complex social environments poses significant challenges. Research on how these challenges impact the performance in specific downstream decision-making tasks is limited. Addressing this gap, we make use of a comprehensive real-world dataset of jobseekers to illustrate how the performance of a single CATE model can vary significantly across different decision-making scenarios and highlight the differential influence of challenges such as distribution shifts on predictions and allocations.

In this paper, we present a data-driven model for estimating optimal rework policies in manufacturing systems. We consider a single production stage within a multistage, lot-based system that allows for optional rework steps. While the rework decision depends on an intermediate state of the lot and system, the final product inspection, and thus the assessment of the actual yield, is delayed until production is complete. Repair steps are applied uniformly to the lot, potentially improving some of the individual items while degrading others. The challenge is thus to balance potential yield improvement with the rework costs incurred. Given the inherently causal nature of this decision problem, we propose a causal model to estimate yield improvement. We apply methods from causal machine learning, in particular double/debiased machine learning (DML) techniques, to estimate conditional treatment effects from data and derive policies for rework decisions. We validate our decision model using real-world data from opto-electronic semiconductor manufacturing, achieving a yield improvement of 2 - 3% during the color-conversion process of white light-emitting diodes (LEDs).

To fight climate change and accommodate the increasing population, global crop production has to be strengthened. To achieve the "sustainable intensification" of agriculture, transforming it from carbon emitter to carbon sink is a priority, and understanding the environmental impact of agricultural management practices is a fundamental prerequisite to that. At the same time, the global agricultural landscape is deeply heterogeneous, with differences in climate, soil, and land use inducing variations in how agricultural systems respond to farmer actions. The "personalization" of sustainable agriculture with the provision of locally adapted management advice is thus a necessary condition for the efficient uplift of green metrics, and an integral development in imminent policies. Here, we formulate personalized sustainable agriculture as a Conditional Average Treatment Effect estimation task and use Causal Machine Learning for tackling it. Leveraging climate data, land use information and employing Double Machine Learning, we estimate the heterogeneous effect of sustainable practices on the field-level Soil Organic Carbon content in Lithuania. We thus provide a data-driven perspective for targeting sustainable practices and effectively expanding the global carbon sink.

"If we really want to build a machine on the verge of human-level intelligence, we need to ditch current statistical and data-driven learning paradigm in favour of a causal-based approach." In the 1970s and early 1980s, computer scientists believed that the manipulation of symbols provided a priori by humans was sufficient for computer systems to exhibit intelligence and solve seemingly hard problems. This hypothesis came to be known as the symbol-rule hypothesis. However, despite some initial encouraging progress, such as computer chess and theorem proving, it soon became apparent that rule-based systems could not solve problems that appear seemingly simple to humans. "It is comparatively easy to make computers exhibit adult level performance […] and difficult or impossible to give them the skills of a one-year-old".

Editor's note: Robert Ness is a speaker for ODSC East 2021. Check out his talk, "Causal Machine Learning Blitz," there! Causal modeling and inference are perhaps at the core of the most interesting questions in data science. A common task for a data scientist at a FAANG is to query users who had exposure to a feature and calculate the correlation between usage of that feature and engagement on the platform. However, the data scientist does not care about that correlation; they care about whether that correlation indicates that the feature drives engagement.

AI should be built on rigorous knowledge... Note: This is a follow-up to an earlier article on causal machine learning, "AI Needs More Why". There's much to be excited about with artificial intelligence (AI) in healthcare: Google AI is improving the workflow of clinicians with predictive models for diabetic retinopathy [2], many new approaches are achieving expert-level performance in tasks such as classification of skin cancer [3], and others surpassing the capabilities of doctors -- notably the recent report of DeepMind's AI for predicting acute kidney disease, capable of detecting potentially fatal kidney injuries 48 hours before symptoms are recognized by doctors [4]. Yet medical practitioners and researchers at the intersection of machine learning (ML) and medicine are quick to point out these successes are not representative of the more nuanced, non-trivial challenges presented by medical research and clinical applications. These ML success stories (notably all deep learning) are disease prediction problems, learning patterns that map well-defined inputs to well-labeled outputs [5]. Domains where instinctive pattern recognition works powerfully are what psychologist Robin Hogarth termed "kind learning environments" [6].

CausalML is a Python implementation of algorithms related to causal inference and machine learning. Algorithms combining causal inference and machine learning have been a trending topic in recent years. This package tries to bridge the gap between theoretical work on methodology and practical applications by making a collection of methods in this field available in Python. This paper introduces the key concepts, scope, and use cases of this package.