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The Truth About 'Addictive Personalities'

TIME - Tech

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Tiny 'chaos potatoes' show off parkour moves

Popular Science

The rabbit-looking rock hyrax is actually related to elephants. More information Adding us as a Preferred Source in Google by using this link indicates that you would like to see more of our content in Google News results. Rock hyraxes reach about 8 pounds. England's Chester Zoo has recently welcomed into the world three rock hyrax () pups. The adorable mammals are tiny, round, adorable--and related to elephants, if you can believe it.


ChatGPT's 'Adult Mode' Could Spark a New Era of Intimate Surveillance

WIRED

The app reads your email inbox and your meeting calendar, then gives you a short audio summary. It can help you spend less time scrolling, but of course, there are privacy drawbacks to consider.


ChatGPT's Horny Era Could Be Its Stickiest Yet

WIRED

ChatGPT's Horny Era Could Be Its Stickiest Yet OpenAI will soon let adults create erotic content in ChatGPT. Experts say that could lead to "emotional commodification," or horniness as a revenue stream. In May of 2024, while I was combing through OpenAI's "Model Spec" laying out how ChatGPT should act, one comment buried in the document struck me as peculiar. It said OpenAI was "exploring" how to let adult ChatGPT users generate content with mature themes such as "erotica, extreme gore, slurs, and unsolicited profanity." Seems like the exploration phase is over.


CellPainTR: Generalizable Representation Learning for Cross-Dataset Cell Painting Analysis

arXiv.org Artificial Intelligence

Large-scale biological discovery requires integrating massive, heterogeneous datasets like those from the JUMP Cell Painting consortium, but technical batch effects and a lack of generalizable models remain critical roadblocks. To address this, we introduce CellPainTR, a Transformer-based architecture designed to learn foundational representations of cellular morphology that are robust to batch effects. Unlike traditional methods that require retraining on new data, CellPainTR's design, featuring source-specific context tokens, allows for effective out-of-distribution (OOD) generalization to entirely unseen datasets without fine-tuning. We validate CellPainTR on the large-scale JUMP dataset, where it outperforms established methods like ComBat and Harmony in both batch integration and biological signal preservation. Critically, we demonstrate its robustness through a challenging OOD task on the unseen Bray et al. dataset, where it maintains high performance despite significant domain and feature shifts. Our work represents a significant step towards creating truly foundational models for image-based profiling, enabling more reliable and scalable cross-study biological analysis.


Machine Learning-driven Multiscale MD Workflows: The Mini-MuMMI Experience

arXiv.org Artificial Intelligence

Computational models have become one of the prevalent methods to model complex phenomena. To accurately model complex interactions, such as detailed biomolecular interactions, scientists often rely on multiscale models comprised of several internal models operating at difference scales, ranging from microscopic to macroscopic length and time scales. Bridging the gap between different time and length scales has historically been challenging but the advent of newer machine learning (ML) approaches has shown promise for tackling that task. Multiscale models require massive amounts of computational power and a powerful workflow management system. Orchestrating ML-driven multiscale studies on parallel systems with thousands of nodes is challenging, the workflow must schedule, allocate and control thousands of simulations operating at different scales. Here, we discuss the massively parallel Multiscale Machine-Learned Modeling Infrastructure (MuMMI), a multiscale workflow management infrastructure, that can orchestrate thousands of molecular dynamics (MD) simulations operating at different timescales, spanning from millisecond to nanosecond. More specifically, we introduce a novel version of MuMMI called "mini-MuMMI". Mini-MuMMI is a curated version of MuMMI designed to run on modest HPC systems or even laptops whereas MuMMI requires larger HPC systems. We demonstrate mini-MuMMI utility by exploring RAS-RAF membrane interactions and discuss the different challenges behind the generalization of multiscale workflows and how mini-MuMMI can be leveraged to target a broader range of applications outside of MD and RAS-RAF interactions.


RxRx3-core: Benchmarking drug-target interactions in High-Content Microscopy

arXiv.org Artificial Intelligence

High Content Screening (HCS) microscopy datasets have transformed the ability to profile cellular responses to genetic and chemical perturbations, enabling cell-based inference of drug-target interactions (DTI). However, the adoption of representation learning methods for HCS data has been hindered by the lack of accessible datasets and robust benchmarks. To address this gap, we present RxRx3-core, a curated and compressed subset of the RxRx3 dataset, and an associated DTI benchmarking task. At just 18GB, RxRx3-core significantly reduces the size barrier associated with large-scale HCS datasets while preserving critical data necessary for benchmarking representation learning models against a zero-shot DTI prediction task. RxRx3-core includes 222,601 microscopy images spanning 736 CRISPR knockouts and 1,674 compounds at 8 concentrations. RxRx3-core is available on HuggingFace and Polaris, along with pre-trained embeddings and benchmarking code, ensuring accessibility for the research community. By providing a compact dataset and robust benchmarks, we aim to accelerate innovation in representation learning methods for HCS data and support the discovery of novel biological insights.


The Morning After: A 6 million fine for robocalls from fake Biden

Engadget

The Federal Communications Commission (FCC) has officially issued its full recommended fine against political consultant Steve Kramer. This is after he initiated a series of robocalls to New Hampshire residents with pre-recorded audio of President Biden's voice, using deepfake AI technology. The fake Biden told voters not to vote in the upcoming primary, saying "Your vote makes a difference in November, not this Tuesday." Kramer must pay 6 million in fines in the next 30 days or the Department of Justice will handle collection, according to a FCC statement. Kramer doesn't just face a fine; he also has criminal charges against him.


FCC fines political consultant 6 million for deepfake robocalls

Engadget

The Federal Communications Commission (FCC) has officially issued its full recommended fine against political consultant Steve Kramer for a series of illegal robocalls using deepfake AI technology and caller ID spoofing during the New Hampshire primaries. Kramer must pay 6 million in fines in the next 30 days or the Department of Justice will handle collection, according to a FCC statement. Kramer violated the Truth in Caller ID Act passed in 2009 that prohibits anyone from "knowingly transmit misleading or inaccurate caller identification information with the intent to defraud, cause harm or wrongfully obtain anything of value," according to legislative records. The law preceded the widespread usage of AI, but the FCC voted unanimously to have it apply to such deepfakes this past February. The phony robocalls delivered pre-recorded audio of President Biden's voice using deepfake AI technology to New Hampshire residents leading up to the 2024 presidential primary election.


The power of Prompts: Evaluating and Mitigating Gender Bias in MT with LLMs

arXiv.org Artificial Intelligence

This paper studies gender bias in machine translation through the lens of Large Language Models (LLMs). Four widely-used test sets are employed to benchmark various base LLMs, comparing their translation quality and gender bias against state-of-the-art Neural Machine Translation (NMT) models for English to Catalan (En $\rightarrow$ Ca) and English to Spanish (En $\rightarrow$ Es) translation directions. Our findings reveal pervasive gender bias across all models, with base LLMs exhibiting a higher degree of bias compared to NMT models. To combat this bias, we explore prompting engineering techniques applied to an instruction-tuned LLM. We identify a prompt structure that significantly reduces gender bias by up to 12% on the WinoMT evaluation dataset compared to more straightforward prompts. These results significantly reduce the gender bias accuracy gap between LLMs and traditional NMT systems.