The COVID-19 infodemic calls for scalable fact-checking solutions that handle long-form misinformation with accuracy and reliability. This study presents SAFE (system for accurate fact extraction and evaluation), an agent system that combines large language models with retrieval-augmented generation (RAG) to improve automated fact-checking of long-form COVID-19 misinformation. SAFE includes two agents - one for claim extraction and another for claim verification using LOTR-RAG, which leverages a 130,000-document COVID-19 research corpus. An enhanced variant, SAFE (LOTR-RAG + SRAG), incorporates Self-RAG to refine retrieval via query rewriting. We evaluated both systems on 50 fake news articles (2-17 pages) containing 246 annotated claims (M = 4.922, SD = 3.186), labeled as true (14.1%), partly true (14.4%), false (27.0%), partly false (2.2%), and misleading (21.0%) by public health professionals. SAFE systems significantly outperformed baseline LLMs in all metrics (p < 0.001). For consistency (0-1 scale), SAFE (LOTR-RAG) scored 0.629, exceeding both SAFE (+SRAG) (0.577) and the baseline (0.279). In subjective evaluations (0-4 Likert scale), SAFE (LOTR-RAG) also achieved the highest average ratings in usefulness (3.640), clearness (3.800), and authenticity (3.526). Adding SRAG slightly reduced overall performance, except for a minor gain in clearness. SAFE demonstrates robust improvements in long-form COVID-19 fact-checking by addressing LLM limitations in consistency and explainability. The core LOTR-RAG design proved more effective than its SRAG-augmented variant, offering a strong foundation for scalable misinformation mitigation.

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A Proposed Federal THC Ban Would'Wipe Out' Hemp Products That Get People High The provision, tucked into the spending bill that could end the US government shutdown, would ban intoxicating hemp-derived THC products, including gummies and drinks. A provision in the federal spending bill that could end the US government shutdown would effectively destroy the hemp extracts industry by banning intoxicating hemp-based THC products, including gummies and drinks. The provision, part of the funding bill passed by the US Senate Monday night, would ban the "unregulated sale of intoxicating hemp-based or hemp-derived products, including delta-8, from being sold online, in gas stations, and corner stores," according to a Senate Appropriations Committee summary of the legislation. The bill, accounting for $26.65 billion in funds, is being voted on in the House of Representatives Wednesday. If passed, President Donald Trump is expected to sign it into law.

Entitled son, 21, of top lawyer mows down police with his Mercedes G-Wagen...as he smiles in his mugshot Trump'humiliates' speaker Mike Johnson in private conversation as government shutdown rumbles on Tupac's humiliating intimate disfigurement revealed... and how his lies to cover it up led to his murder'I'm Madeline - and this is what I have to say to Lily Allen': Read world exclusive reveal of mother who had affair with star's husband David Harbour, how it started and how she feels about THOSE texts being exposed Loved up Katy Perry holds hands with Justin Trudeau as they officially confirm romance while celebrating the singer's birthday in Paris Furrow-browed boyfriend'strangled girlfriend and set her house on fire while newborn baby was inside' I've uncovered my husband's filthy Viagra habit: But, warns DEAR JANE, one thing YOU are doing is making it so much worse I've started having heart palpitations. Jackie Kennedy's revenge romance with American political icon: Revealed for first time in titillating love letters, the man who helped her cope with JFK's cheating The night that haunted a Wisconsin town forever... and the little girl whose trick-or-treat next door ended in horror Why going gray may save you from CANCER... as scientists make bombshell breakthrough Brazen demands for flying private REVEALED by the woman paid to fulfill them: 'Answer is always yes' They sneered at Trump's'eagle graveyards' - but now Biden's hated windmills crippling an American legend are haunting the US military Kim Kardashian's just been caught in a despicable lie. She can cry all she wants... there's no hiding the truth now: CAROLINE BULLOCK Tua Tagovailoa's swollen eye sparks concern after Dolphins QB woke up with mystery illness on day of Falcons game JD Vance's wife is given secret role in Trump's deal-making inner circle: 'I'll have Usha look at it' The Biden blunder that allowed an alleged October 7 'monster' to become a restaurant worker in Louisiana How I reversed my hair loss and lost 8 stone aged 45 - without weight-loss jabs. Urgent warning over cannabis as UK's top psychiatrist warns it isn't safe for young brains still developing It may seem like a relatively harmless right of passage. But cannabis isn't safe for young brains still developing, the UK's top psychiatrist has warned.

Introduction: Substance use disorders (SUDs) have emerged as a pressing public health crisis in the United States, with adolescent substance use often leading to SUDs in adulthood. Effective strategies are needed to prevent this progression. To help in filling this need, we develop a novel and the first-ever absolute risk prediction model for cannabis use disorder (CUD) for adolescent or young adult cannabis users. Methods: We train a Bayesian machine learning model that provides a personalized CUD absolute risk for adolescent or young adult cannabis users using data from the National Longitudinal Study of Adolescent to Adult Health. Model performance is assessed using 5-fold cross-validation (CV) with area under the curve (AUC) and ratio of the expected to observed number of cases (E/O). External validation of the final model is conducted using two independent datasets. Results: The proposed model has five risk factors: biological sex, delinquency, and scores on personality traits of conscientiousness, neuroticism, and openness. For predicting CUD risk within five years of first cannabis use, AUC and E/O, computed via 5-fold CV, were 0.68 and 0.95, respectively. For the same type of prediction in external validation, AUC values were 0.64 and 0.75, with E/O values of 0.98 and 1, indicating good discrimination and calibration performances of the model. Discussion and Conclusion: The proposed model is the first absolute risk prediction model for an SUD. It can aid clinicians in identifying adolescent/youth substance users at a high risk of developing CUD in future for clinically appropriate interventions.

Wearable sensor systems have demonstrated a great potential for real-time, objective monitoring of physiological health to support behavioral interventions. However, obtaining accurate labels in free-living environments remains difficult due to limited human supervision and the reliance on self-labeling by patients, making data collection and supervised learning particularly challenging. To address this issue, we introduce CUDLE (Cannabis Use Detection with Label Efficiency), a novel framework that leverages self-supervised learning with real-world wearable sensor data to tackle a pressing healthcare challenge: the automatic detection of cannabis consumption in free-living environments. CUDLE identifies cannabis consumption moments using sensor-derived data through a contrastive learning framework. It first learns robust representations via a self-supervised pretext task with data augmentation. These representations are then fine-tuned in a downstream task with a shallow classifier, enabling CUDLE to outperform traditional supervised methods, especially with limited labeled data. To evaluate our approach, we conducted a clinical study with 20 cannabis users, collecting over 500 hours of wearable sensor data alongside user-reported cannabis use moments through EMA (Ecological Momentary Assessment) methods. Our extensive analysis using the collected data shows that CUDLE achieves a higher accuracy of 73.4%, compared to 71.1% for the supervised approach, with the performance gap widening as the number of labels decreases. Notably, CUDLE not only surpasses the supervised model while using 75% less labels, but also reaches peak performance with far fewer subjects.

The escalating prevalence of cannabis use poses a significant public health challenge globally. In the U.S., cannabis use is more prevalent among emerging adults (EAs) (ages 18-25) than any other age group, with legalization in the multiple states contributing to a public perception that cannabis is less risky than in prior decades. To address this growing concern, we developed MiWaves, a reinforcement learning (RL) algorithm designed to optimize the delivery of personalized intervention prompts to reduce cannabis use among EAs. MiWaves leverages domain expertise and prior data to tailor the likelihood of delivery of intervention messages. This paper presents a comprehensive overview of the algorithm's design, including key decisions and experimental outcomes. The finalized MiWaves RL algorithm was deployed in a clinical trial from March to May 2024.

Researchers in the political and social sciences often rely on classification models to analyze trends in information consumption by examining browsing histories of millions of webpages. Automated scalable methods are necessary due to the impracticality of manual labeling. In this paper, we model the detection of topic-related content as a binary classification task and compare the accuracy of fine-tuned pre-trained encoder models against in-context learning strategies. Using only a few hundred annotated data points per topic, we detect content related to three German policies in a database of scraped webpages. We compare multilingual and monolingual models, as well as zero and few-shot approaches, and investigate the impact of negative sampling strategies and the combination of URL & content-based features. Our results show that a small sample of annotated data is sufficient to train an effective classifier. Fine-tuning encoder-based models yields better results than in-context learning. Classifiers using both URL & content-based features perform best, while using URLs alone provides adequate results when content is unavailable.

The escalating prevalence of cannabis use, and associated cannabis-use disorder (CUD), poses a significant public health challenge globally. With a notably wide treatment gap, especially among emerging adults (EAs; ages 18-25), addressing cannabis use and CUD remains a pivotal objective within the 2030 United Nations Agenda for Sustainable Development Goals (SDG). In this work, we develop an online reinforcement learning (RL) algorithm called reBandit which will be utilized in a mobile health study to deliver personalized mobile health interventions aimed at reducing cannabis use among EAs. reBandit utilizes random effects and informative Bayesian priors to learn quickly and efficiently in noisy mobile health environments. Moreover, reBandit employs Empirical Bayes and optimization techniques to autonomously update its hyper-parameters online. To evaluate the performance of our algorithm, we construct a simulation testbed using data from a prior study, and compare against commonly used algorithms in mobile health studies. We show that reBandit performs equally well or better than all the baseline algorithms, and the performance gap widens as population heterogeneity increases in the simulation environment, proving its adeptness to adapt to diverse population of study participants.

The excessive consumption of marijuana can induce substantial psychological and social consequences. In this investigation, we propose an elucidative framework termed high-order graph attention neural networks (HOGANN) for the classification of Marijuana addiction, coupled with an analysis of localized brain network communities exhibiting abnormal activities among chronic marijuana users. HOGANN integrates dynamic intrinsic functional brain networks, estimated from resting-state functional magnetic resonance imaging (rs-fMRI), using long short-term memory (LSTM) to capture temporal network dynamics. We employ a high-order attention module for information fusion and message passing among neighboring nodes, enhancing the network community analysis. Our model is validated across two distinct data cohorts, yielding substantially higher classification accuracy than benchmark algorithms. Furthermore, we discern the most pertinent subnetworks and cognitive regions affected by persistent marijuana consumption, indicating adverse effects on functional brain networks, particularly within the dorsal attention and frontoparietal networks. Intriguingly, our model demonstrates superior performance in cohorts exhibiting prolonged dependence, implying that prolonged marijuana usage induces more pronounced alterations in brain networks. The model proficiently identifies craving brain maps, thereby delineating critical brain regions for analysis.