The central objective of empirical asset pricing is to identify firm-level signals that explain the cross-section of expected stock returns--whether through exposure to risk factors or persistent mispricing. The dominant paradigm, grounded in the assumption of self-predictability, asserts that a firm's own characteristics forecast its own returns (see, e.g., Cochrane (2011); Harvey et al. (2016)). Complementing this view is a growing literature on cross-predictability--the idea that the characteristics or returns of one asset can help forecast the returns of others (see, e.g., Lo and MacKinlay (1990); Hou (2007); Cohen and Frazzini (2008); Cohen and Lou (2012); Huang et al. (2021, 2022)). A key mechanism underpinning this phenomenon is the presence of lead-lag effects, whereby price movements or information from one firm precede and predict those of related firms. Such effects can stem from staggered information diffusion, peer influence within industries, supply chain linkages, or correlated trading by institutional investors that induces price pressure across related assets. Despite recent methodological advances in modeling cross-stock predictability, several foundational questions remain unresolved. Chief among them is how a mean-variance investor can analytically integrate multiple predictive signals when returns are interconnected across assets. Equally crucial is developing a framework that jointly captures both the relevance of individual signals and the structure of return spillovers--enhancing portfolio performance while preserving interpretability .

We study the optimization of functions with $n>2$ arguments that have a representation as a sum of several functions that have only $2$ of the $n$ arguments each, termed sums of bivariates, on finite domains. The complexity of optimizing sums of bivariates is shown to be NP-equivalent and it is shown that there exists free lunch in the optimization of sums of bivariates. Based on measure-valued extensions of the objective function, so-called relaxations, $\ell^2$-approximation, and entropy-regularization, we derive several tractable problem formulations solvable with linear programming, coordinate ascent as well as with closed-form solutions. The limits of applying tractable versions of such relaxations to sums of bivariates are investigated using general results for reconstructing measures from their bivariate marginals. Experiments in which the derived algorithms are applied to random functions, vertex coloring, and signal reconstruction problems provide insights into qualitatively different function classes that can be modeled as sums of bivariates.

Scientists have developed hundreds of techniques to measure the interactions between pairs of processes in complex systems. But these computational methods, from correlation coefficients to causal inference, rely on distinct quantitative theories that remain largely disconnected. Here we introduce a library of 237 statistics of pairwise interactions and assess their behavior on 1053 multivariate time series from a wide range of real-world and model-generated systems. Our analysis highlights new commonalities between different mathematical formulations, providing a unified picture of a rich interdisciplinary literature. Using three real-world case studies, we then show that simultaneously leveraging diverse methods from across science can uncover those most suitable for addressing a given problem, yielding interpretable understanding of the conceptual formulations of pairwise dependence that drive successful performance. Our framework is provided in extendable open software, enabling comprehensive data-driven analysis by integrating decades of methodological advances.

Estimation of individual treatment effect in observational data is complicated due to the challenges of confounding and selection bias. A useful inferential framework to address this is the counterfactual (potential outcomes) model which takes the hypothetical stance of asking what if an individual had received both treatments. Making use of random forests (RF) within the counterfactual framework we estimate individual treatment effects by directly modeling the response. We find accurate estimation of individual treatment effects is possible even in complex heterogeneous settings but that the type of RF approach plays an important role in accuracy. Methods designed to be adaptive to confounding, when used in parallel with out-of-sample estimation, do best. One method found to be especially promising is counterfactual synthetic forests. We illustrate this new methodology by applying it to a large comparative effectiveness trial, Project Aware, in order to explore the role drug use plays in sexual risk. The analysis reveals important connections between risky behavior, drug usage, and sexual risk.