Accurate and reliable Magnetic Resonance Imaging (MRI) analysis is particularly important for adaptive radiotherapy, a recent medical advance capable of improving cancer diagnosis and treatment. Recent studies have shown that IVIM-NET, a deep neural network (DNN), can achieve high accuracy in MRI analysis, indicating the potential of deep learning to enhance diagnostic capabilities in healthcare. However, IVIM-NET does not provide calibrated uncertainty information needed for reliable and trustworthy predictions in healthcare. Moreover, the expensive computation and memory demands of IVIM-NET reduce hardware performance, hindering widespread adoption in realistic scenarios. To address these challenges, this paper proposes an algorithm-hardware co-optimization flow for high-performance and reliable MRI analysis. At the algorithm level, a transformation design flow is introduced to convert IVIM-NET to a mask-based Bayesian Neural Network (BayesNN), facilitating reliable and efficient uncertainty estimation. At the hardware level, we propose an FPGA-based accelerator with several hardware optimizations, such as mask-zero skipping and operation reordering. Experimental results demonstrate that our co-design approach can satisfy the uncertainty requirements of MRI analysis, while achieving 7.5 times and 32.5 times speedup on an Xilinx VU13P FPGA compared to GPU and CPU implementations with reduced power consumption.

Reliable uncertainty estimation plays a crucial role in various safety-critical applications such as medical diagnosis and autonomous driving. In recent years, Bayesian neural networks (BayesNNs) have gained substantial research and industrial interests due to their capability to make accurate predictions with reliable uncertainty estimation. However, the algorithmic complexity and the resulting hardware performance of BayesNNs hinder their adoption in real-life applications. To bridge this gap, this paper proposes an algorithm and hardware co-design framework that can generate field-programmable gate array (FPGA)-based accelerators for efficient BayesNNs. At the algorithm level, we propose novel multi-exit dropout-based BayesNNs with reduced computational and memory overheads while achieving high accuracy and quality of uncertainty estimation. At the hardware level, this paper introduces a transformation framework that can generate FPGA-based accelerators for the proposed efficient multi-exit BayesNNs. Several optimization techniques such as the mix of spatial and temporal mappings are introduced to reduce resource consumption and improve the overall hardware performance. Comprehensive experiments demonstrate that our approach can achieve higher energy efficiency compared to CPU, GPU, and other state-of-the-art hardware implementations. To support the future development of this research, we have open-sourced our code at: https://github.com/os-hxfan/MCME_FPGA_Acc.git

The increasing deployment of artificial intelligence (AI) for critical decision-making amplifies the necessity for trustworthy AI, where uncertainty estimation plays a pivotal role in ensuring trustworthiness. Dropout-based Bayesian Neural Networks (BayesNNs) are prominent in this field, offering reliable uncertainty estimates. Despite their effectiveness, existing dropout-based BayesNNs typically employ a uniform dropout design across different layers, leading to suboptimal performance. Moreover, as diverse applications require tailored dropout strategies for optimal performance, manually optimizing dropout configurations for various applications is both error-prone and labor-intensive. To address these challenges, this paper proposes a novel neural dropout search framework that automatically optimizes both the dropout-based BayesNNs and their hardware implementations on FPGA. We leverage one-shot supernet training with an evolutionary algorithm for efficient dropout optimization. A layer-wise dropout search space is introduced to enable the automatic design of dropout-based BayesNNs with heterogeneous dropout configurations. Extensive experiments demonstrate that our proposed framework can effectively find design configurations on the Pareto frontier. Compared to manually-designed dropout-based BayesNNs on GPU, our search approach produces FPGA designs that can achieve up to 33X higher energy efficiency. Compared to state-of-the-art FPGA designs of BayesNN, the solutions from our approach can achieve higher algorithmic performance and energy efficiency.

Bayesian Neural Networks (BayesNNs) have demonstrated their capability of providing calibrated prediction for safety-critical applications such as medical imaging and autonomous driving. However, the high algorithmic complexity and the poor hardware performance of BayesNNs hinder their deployment in real-life applications. To bridge this gap, this paper proposes a novel multi-exit Monte-Carlo Dropout (MCD)-based BayesNN that achieves well-calibrated predictions with low algorithmic complexity. To further reduce the barrier to adopting BayesNNs, we propose a transformation framework that can generate FPGA-based accelerators for multi-exit MCD-based BayesNNs. Several novel optimization techniques are introduced to improve hardware performance. Our experiments demonstrate that our auto-generated accelerator achieves higher energy efficiency than CPU, GPU, and other state-of-the-art hardware implementations.