Automatic diagnosis is a significant application of AI in healthcare, where diagnoses are generated based on the symptom description of patients. Previous works have approached this task directly by modeling the relationship between the normalized symptoms and all possible diseases. However, in the clinical diagnostic process, patients are initially consulted by a general practitioner and, if necessary, referred to specialists in specific domains for a more comprehensive evaluation. The final diagnosis often emerges from a collaborative consultation among medical specialist groups. Recently, large language models have shown impressive capabilities in natural language understanding. In this study, we adopt tuning-free LLM-based agents as medical practitioners and propose the Agent-derived Multi-Specialist Consultation (AMSC) framework to model the diagnosis process in the real world by adaptively fusing probability distributions of agents over potential diseases. Experimental results demonstrate the superiority of our approach compared with baselines. Notably, our approach requires significantly less parameter updating and training time, enhancing efficiency and practical utility. Furthermore, we delve into a novel perspective on the role of implicit symptoms within the context of automatic diagnosis.

Motivation: Disease diagnosis oriented dialogue system models the interactive consultation procedure as Markov Decision Process and reinforcement learning algorithms are used to solve the problem. Existing approaches usually employ a flat policy structure that treat all symptoms and diseases equally for action making. This strategy works well in the simple scenario when the action space is small, however, its efficiency will be challenged in the real environment. Inspired by the offline consultation process, we propose to integrate a hierarchical policy structure of two levels into the dialogue systemfor policy learning. The high-level policy consists of amastermodel that is responsible for triggering a low-levelmodel, the lowlevel policy consists of several symptom checkers and a disease classifier. The proposed policy structure is capable to deal with diagnosis problem including large number of diseases and symptoms. Results: Experimental results on three real-world datasets and a synthetic dataset demonstrate that our hierarchical framework achieves higher accuracy and symptom recall in disease diagnosis compared with existing systems. We construct a benchmark including datasets and implementation of existing algorithms to encourage follow-up researches. Availability: The code and data is available from https://github.com/FudanDISC/DISCOpen-MedBox-DialoDiagnosis Contact: 21210980124@m.fudan.edu.cn Supplementary information: Supplementary data are available at Bioinformatics online.

Automatic diagnosis (AD), a critical application of AI in healthcare, employs machine learning techniques to assist doctors in gathering patient symptom information for precise disease diagnosis. The Transformer-based method utilizes an input symptom sequence, predicts itself through auto-regression, and employs the hidden state of the final symptom to determine the disease. Despite its simplicity and superior performance demonstrated, a decline in disease diagnosis accuracy is observed caused by 1) a mismatch between symptoms observed during training and generation, and 2) the effect of different symptom orders on disease prediction. To address the above obstacles, we introduce the CoAD, a novel disease and symptom collaborative generation framework, which incorporates several key innovations to improve AD: 1) aligning sentence-level disease labels with multiple possible symptom inquiry steps to bridge the gap between training and generation; 2) expanding symptom labels for each sub-sequence of symptoms to enhance annotation and eliminate the effect of symptom order; 3) developing a repeated symptom input schema to effectively and efficiently learn the expanded disease and symptom labels. We evaluate the CoAD framework using four datasets, including three public and one private, and demonstrate that it achieves an average 2.3% improvement over previous state-of-the-art results in automatic disease diagnosis. For reproducibility, we release the code and data at https://github.com/KwanWaiChung/coad.

Diagnosis-oriented dialogue system queries the patient's health condition and makes predictions about possible diseases through continuous interaction with the patient. A few studies use reinforcement learning (RL) to learn the optimal policy from the joint action space of symptoms and diseases. However, existing RL (or Non-RL) methods cannot achieve sufficiently good prediction accuracy, still far from its upper limit. To address the problem, we propose a decoupled automatic diagnostic framework DxFormer, which divides the diagnosis process into two steps: symptom inquiry and disease diagnosis, where the transition from symptom inquiry to disease diagnosis is explicitly determined by the stopping criteria. In DxFormer, we treat each symptom as a token, and formalize the symptom inquiry and disease diagnosis to a language generation model and a sequence classification model respectively. We use the inverted version of Transformer, i.e., the decoder-encoder structure, to learn the representation of symptoms by jointly optimizing the reinforce reward and cross entropy loss. Extensive experiments on three public real-world datasets prove that our proposed model can effectively learn doctors' clinical experience and achieve the state-of-the-art results in terms of symptom recall and diagnostic accuracy.

Background: Distinguishing gastric epithelial regeneration change from dysplasia and histopathological diagnosis of dysplasia is subject to interobserver disagreement in endoscopic specimens. In this study, we developed a method to distinguish gastric epithelial regeneration change from dysplasia and further subclassify dysplasia. Methods: 897 whole slide images (WSIs) of endoscopic specimens from two hospitals were divided into training, internal validation, and external validation cohorts. We developed a deep learning (DL) with DA (DLDA) model to classify gastric dysplasia and epithelial regeneration change into three categories: negative for dysplasia (NFD), low-grade dysplasia (LGD), and high-grade dysplasia (HGD)/intramucosal invasion neoplasia (IMN). The diagnosis based on the DLDA model was compared to 12 pathologists using 100 gastric biopsy cases.

Automatic diagnosis has attracted increasing attention but remains challenging due to multi-step reasoning. Recent works usually address it by reinforcement learning methods. However, these methods show low efficiency and require taskspecific reward functions. Considering the conversation between doctor and patient allows doctors to probe for symptoms and make diagnoses, the diagnosis process can be naturally seen as the generation of a sequence including symptoms and diagnoses. Inspired by this, we reformulate automatic diagnosis as a symptoms Sequence Generation (SG) task and propose a simple but effective automatic Diagnosis model based on Transformer (Diaformer). We firstly design the symptom attention framework to learn the generation of symptom inquiry and the disease diagnosis. To alleviate the discrepancy between sequential generation and disorder of implicit symptoms, we further design three orderless training mechanisms. Experiments on three public datasets show that our model outperforms baselines on disease diagnosis by 1%, 6% and 11.5% with the highest training efficiency. Detailed analysis on symptom inquiry prediction demonstrates that the potential of applying symptoms sequence generation for automatic diagnosis.

The medical automatic diagnosis system aims to imitate human doctors in the real diagnostic process. This task is formulated as a sequential decision-making problem with symptom inquiring and disease diagnosis. In recent years, many researchers have used reinforcement learning methods to handle this task. However, most recent works neglected to distinguish the symptom inquiring and disease diagnosing actions and mixed them into one action space. This results in the unsatisfactory performance of reinforcement learning methods on this task. Moreover, there is a lack of a public evaluation dataset that contains various diseases and corresponding information. To address these issues, we first propose a novel method for medical automatic diagnosis with symptom inquiring and disease diagnosing formulated as a reinforcement learning task and a classification task, respectively. We also propose a robust and adaptive method to align the two tasks using distribution entropies as media. Then, we create a new dataset extracted from the MedlinePlus knowledge base. The dataset contains more diseases and more complete symptom information. The simulated patients for experiments are more realistic. Experimental evaluation results show that our method outperforms three recent state-of-the-art methods on different datasets by achieving higher medical diagnosis accuracies with few inquiring turns.

Clinical diagnosis, which aims to assign diagnosis codes for a patient based on the clinical note, plays an essential role in clinical decision-making. Considering that manual diagnosis could be error-prone and time-consuming, many intelligent approaches based on clinical text mining have been proposed to perform automatic diagnosis. However, these methods may not achieve satisfactory results due to the following challenges. First, most of the diagnosis codes are rare, and the distribution is extremely unbalanced. Second, existing methods are challenging to capture the correlation between diagnosis codes. Third, the lengthy clinical note leads to the excessive dispersion of key information related to codes. To tackle these challenges, we propose a novel framework to combine the inheritance-guided hierarchical assignment and co-occurrence graph propagation for clinical automatic diagnosis. Specifically, we propose a hierarchical joint prediction strategy to address the challenge of unbalanced codes distribution. Then, we utilize graph convolutional neural networks to obtain the correlation and semantic representations of medical ontology. Furthermore, we introduce multi attention mechanisms to extract crucial information. Finally, extensive experiments on MIMIC-III dataset clearly validate the effectiveness of our method.

The main purpose of the study was to develop a high accuracy system able to diagnose skin lesions using deep learning–based methods. We propose a new decision system based on multiple classifiers like neural networks and feature–based methods. Each classifier (method) gives the final decision system a certain weight, depending on the calculated accuracy, helping the system make a better decision. First, we created a neural network (NN) that can differentiate melanoma from benign nevus. The NN architecture is analyzed by evaluating it during the training process.

The manufacturing sector is envisioned to be heavily influenced by artificial intelligence-based technologies with the extraordinary increases in computational power and data volumes. Data-driven methods use sensor data, such as vibration, pressure, temperature, and energy data to extract useful features for diagnosis and prediction. A central challenge in manufacturing sector lies in the requirement of a general framework to ensure satisfied diagnosis and monitoring performances in different manufacturing applications. In a new research article published in the Beijing-based National Science Review, Prof. Ye Yuan from the School of Artificial Intelligence and Automation and Prof. Han Ding from the State Key Laboratory of Digital Manufacturing Equipment and Technology, Huazhong University of Science and Technology, jointly proposed an end-to-end diagnostic framework that can be used in diverse manufacturing systems. This framework exploits the predictive power of convolutional neural network to automatically extract hidden degradation features from noisy time-course data.