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An international retrospective study finds that infection with SARS-CoV-2, the virus that causes COVID-19, creates subtle electrical changes in the heart. An AI-enhanced EKG can detect these changes and potentially be used as a rapid, reliable COVID-19 screening test to rule out COVID-19 infection. The AI-enhanced EKG was able to detect COVID-19 infection in the test with a positive predictive value -- people infected -- of 37% and a negative predictive value -- people not infected -- of 91%. When additional normal control subjects were added to reflect a 5% prevalence of COVID-19 -- similar to a real-world population -- the negative predictive value jumped to 99.2%. The findings are published in Mayo Clinic Proceedings.

It would be easy to wonder what Zachi Attia is doing in the cardiac operating rooms of one of America's most prestigious hospitals. He has no formal medical training or surgical expertise. The first time he watched a live procedure, he worried he might faint. But at Mayo Clinic, the 33-year-old machine learning engineer has become a central figure in one of the nation's most ambitious efforts to revamp heart disease treatment using artificial intelligence. Working side by side with physicians, he has built algorithms that in studies have shown a remarkable ability to unmask heart abnormalities long before patients begin experiencing symptoms.

Artificial intelligence (AI) can detect signs of existing or emerging A-fib in ECGs that exhibit normal sinus rhythm, Mayo Clinic researchers have found. Their retrospective analysis, published online yesterday in the Lancet, reports a high degree of accuracy with only one ECG, and this accuracy increases when AI is applied to multiple ECGs from the same patient. "A very common clinical scenario is that someone comes to the hospital with an ischemic stroke, and we want to know whether they have atrial fibrillation," senior author Paul A. Friedman, MD (Mayo Clinic, Rochester, MN), noted to TCTMD. "We have done previous work using neural networks, machine learning, that found that it was extremely powerful in detecting subtle patterns [in ECG tracings], and we wondered: If someone had atrial fibrillation yesterday, is there any way that it might leave a trace of a finding on an ECG today that's too subtle for a human to read but a computer could pick up?" To find out, the investigators, led by Zachi I. Attia, MSc, and Peter A. Noseworthy, MD, drew upon records in the Mayo Clinic Digital Data Vault.