We present the first federated learning (FL) approach for pancreas part (head, body, tail) segmentation in MRI, addressing a critical clinical challenge as a significant innovation. Pancreatic diseases exhibit marked regional heterogeneity--cancers predominantly occur in the head region while chronic pancreatitis causes tissue loss in the tail--making accurate segmentation of the organ into head, body, and tail regions essential for precise diagnosis and treatment planning. This segmentation task remains exceptionally challenging in MRI due to variable morphology, poor soft-tissue contrast, and anatomical variations across patients. Our novel contribution tackles two fundamental challenges: first, the technical complexity of pancreas part delineation in MRI, and second the data scarcity problem that has hindered prior approaches. We introduce a privacy-preserving FL framework that enables collaborative model training across seven medical institutions without direct data sharing, leveraging a diverse dataset of 711 T1W and 726 T2W MRI scans. Our key innovations include: (1) a systematic evaluation of three state-of-the-art segmentation architectures (U-Net, Attention U-Net,Swin UNETR) paired with two FL algorithms (FedA vg, FedProx), revealing Attention U-Net with FedAvg as optimal for pancreatic heterogeneity, which was never been done before; (2) a novel anatomically-informed loss function prioritizing region-specific texture contrasts in MRI. Comprehensive evaluation demonstrates that our approach achieves clinically viable performance despite training on distributed, heterogeneous datasets.

During irradiation, phenomena such as kernel swelling and buffer densification may impact the performance of tristructural isotropic (TRISO) particle fuel. Post-irradiation microscopy is often used to identify these irradiation-induced morphologic changes. However, each fuel compact generally contains thousands of TRISO particles. Manually performing the work to get statistical information on these phenomena is cumbersome and subjective. To reduce the subjectivity inherent in that process and to accelerate data analysis, we used convolutional neural networks (CNNs) to automatically segment cross-sectional images of microscopic TRISO layers. CNNs are a class of machine-learning algorithms specifically designed for processing structured grid data. They have gained popularity in recent years due to their remarkable performance in various computer vision tasks, including image classification, object detection, and image segmentation. In this research, we generated a large irradiated TRISO layer dataset with more than 2,000 microscopic images of cross-sectional TRISO particles and the corresponding annotated images. Based on these annotated images, we used different CNNs to automatically segment different TRISO layers. These CNNs include RU-Net (developed in this study), as well as three existing architectures: U-Net, Residual Network (ResNet), and Attention U-Net. The preliminary results show that the model based on RU-Net performs best in terms of Intersection over Union (IoU). Using CNN models, we can expedite the analysis of TRISO particle cross sections, significantly reducing the manual labor involved and improving the objectivity of the segmentation results.

This study performs a comprehensive evaluation of quantitative measurements as extracted from automated deep-learning-based segmentation methods, beyond traditional Dice Similarity Coefficient assessments, focusing on six quantitative metrics, namely SUVmax, SUVmean, total lesion activity (TLA), tumor volume (TMTV), lesion count, and lesion spread. We analyzed 380 prostate-specific membrane antigen (PSMA) targeted [18F]DCFPyL PET/CT scans of patients with biochemical recurrence of prostate cancer, training deep neural networks, U-Net, Attention U-Net and SegResNet with four loss functions: Dice Loss, Dice Cross Entropy, Dice Focal Loss, and our proposed L1 weighted Dice Focal Loss (L1DFL). Evaluations indicated that Attention U-Net paired with L1DFL achieved the strongest correlation with the ground truth (concordance correlation = 0.90-0.99 for SUVmax and TLA), whereas models employing the Dice Loss and the other two compound losses, particularly with SegResNet, underperformed. Equivalence testing (TOST, alpha = 0.05, Delta = 20%) confirmed high performance for SUV metrics, lesion count and TLA, with L1DFL yielding the best performance. By contrast, tumor volume and lesion spread exhibited greater variability. Bland-Altman, Coverage Probability, and Total Deviation Index analyses further highlighted that our proposed L1DFL minimizes variability in quantification of the ground truth clinical measures. The code is publicly available at: https://github.com/ObedDzik/pca\_segment.git.

This study addresses the challenge of reconstructing unseen ECG signals from PPG signals, a critical task for non-invasive cardiac monitoring. While numerous public ECG-PPG datasets are available, they lack the diversity seen in image datasets, and data collection processes often introduce noise, complicating ECG reconstruction from PPG even with advanced machine learning models. To tackle these challenges, we first introduce a novel synthetic ECG-PPG data generation technique using an ODE model to enhance training diversity. Next, we develop a novel subject-independent PPG-to-ECG reconstruction model that integrates contrastive learning, adversarial learning, and attention gating, achieving results comparable to or even surpassing existing approaches for unseen ECG reconstruction. Finally, we examine factors such as sex and age that impact reconstruction accuracy, emphasizing the importance of considering demographic diversity during model training and dataset augmentation.

This study proposes a new loss function for deep neural networks, L1-weighted Dice Focal Loss (L1DFL), that leverages L1 norms for adaptive weighting of voxels based on their classification difficulty, towards automated detection and segmentation of metastatic prostate cancer lesions in PET/CT scans. We obtained 380 PSMA [18-F] DCFPyL PET/CT scans of patients diagnosed with biochemical recurrence metastatic prostate cancer. We trained two 3D convolutional neural networks, Attention U-Net and SegResNet, and concatenated the PET and CT volumes channel-wise as input. The performance of our custom loss function was evaluated against the Dice and Dice Focal Loss functions. For clinical significance, we considered a detected region of interest (ROI) as a true positive if at least the voxel with the maximum standardized uptake value falls within the ROI. We assessed the models' performance based on the number of lesions in an image, tumour volume, activity, and extent of spread. The L1DFL outperformed the comparative loss functions by at least 13% on the test set. In addition, the F1 scores of the Dice Loss and the Dice Focal Loss were lower than that of L1DFL by at least 6% and 34%, respectively. The Dice Focal Loss yielded more false positives, whereas the Dice Loss was more sensitive to smaller volumes and struggled to segment larger lesions accurately. They also exhibited network-specific variations and yielded declines in segmentation accuracy with increased tumour spread. Our results demonstrate the potential of L1DFL to yield robust segmentation of metastatic prostate cancer lesions in PSMA PET/CT images. The results further highlight potential complexities arising from the variations in lesion characteristics that may influence automated prostate cancer tumour detection and segmentation. The code is publicly available at: https://github.com/ObedDzik/pca_segment.git.

In light of growing threats posed by climate change in general and sea level rise (SLR) in particular, the necessity for computationally efficient means to estimate and analyze potential coastal flood hazards has become increasingly pressing. Data-driven supervised learning methods serve as promising candidates that can dramatically expedite the process, thereby eliminating the computational bottleneck associated with traditional physics-based hydrodynamic simulators. Yet, the development of accurate and reliable coastal flood prediction models, especially those based on Deep Learning (DL) techniques, has been plagued with two major issues: (1) the scarcity of training data and (2) the high-dimensional output required for detailed inundation mapping. To remove this barrier, we present a systematic framework for training high-fidelity Deep Vision-based coastal flood prediction models in low-data settings. We test the proposed workflow on different existing vision models, including a fully transformer-based architecture and a Convolutional Neural Network (CNN) with additive attention gates. Additionally, we introduce a deep CNN architecture tailored specifically to the coastal flood prediction problem at hand. The model was designed with a particular focus on its compactness so as to cater to resource-constrained scenarios and accessibility aspects. The performance of the developed DL models is validated against commonly adopted geostatistical regression methods and traditional Machine Learning (ML) approaches, demonstrating substantial improvement in prediction quality. Lastly, we round up the contributions by providing a meticulously curated dataset of synthetic flood inundation maps of Abu Dhabi's coast produced with a physics-based hydrodynamic simulator, which can serve as a benchmark for evaluating future coastal flood prediction models.

In Total Knee Replacement Arthroplasty (TKA), surgical robotics can provide image-guided navigation to fit implants with high precision. Its tracking approach highly relies on inserting bone pins into the bones tracked by the optical tracking system. This is normally done by invasive, radiative manners (implantable markers and CT scans), which introduce unnecessary trauma and prolong the preparation time for patients. To tackle this issue, ultrasound-based bone tracking could offer an alternative. In this study, we proposed a novel deep learning structure to improve the accuracy of bone tracking by an A-mode ultrasound (US). We first obtained a set of ultrasound dataset from the cadaver experiment, where the ground truth locations of bones were calculated using bone pins. These data were used to train the proposed CasAtt-UNet to predict bone location automatically and robustly. The ground truth bone locations and those locations of US were recorded simultaneously. Therefore, we could label bone peaks in the raw US signals. As a result, our method achieved sub millimeter precision across all eight bone areas with the only exception of one channel in the ankle. This method enables the robust measurement of lower extremity bone positions from 1D raw ultrasound signals. It shows great potential to apply A-mode ultrasound in orthopedic surgery from safe, convenient, and efficient perspectives.

Medical imaging refers to the technologies and methods utilized to view the human body and its inside, in order to diagnose, monitor, or even treat medical disorders. This paper aims to explore the application of deep learning techniques in the semantic segmentation of Cardiac short-axis MRI (Magnetic Resonance Imaging) images, aiming to enhance the diagnosis, monitoring, and treatment of medical disorders related to the heart. The focus centers on implementing various architectures that are derivatives of U-Net, to effectively isolate specific parts of the heart for comprehensive anatomical and functional analysis. Through a combination of images, graphs, and quantitative metrics, the efficacy of the models and their predictions are showcased. Additionally, this paper addresses encountered challenges and outline strategies for future improvements. This abstract provides a concise overview of the efforts in utilizing deep learning for cardiac image segmentation, emphasizing both the accomplishments and areas for further refinement.

Radiofrequency ablation (RFA) is a widely used minimally invasive technique for ablating solid tumors. Achieving precise personalized treatment necessitates feedback information on in situ thermal effects induced by the RFA procedure. While computer simulation facilitates the prediction of electrical and thermal phenomena associated with RFA, its practical implementation in clinical settings is hindered by high computational demands. In this paper, we propose a physics-guided neural network model, named PhysRFANet, to enable real-time prediction of thermal effect during RFA treatment. The networks, designed for predicting temperature distribution and the corresponding ablation lesion, were trained using biophysical computational models that integrated electrostatics, bio-heat transfer, and cell necrosis, alongside magnetic resonance (MR) images of breast cancer patients. Validation of the computational model was performed through experiments on ex vivo bovine liver tissue. Our model demonstrated a 96% Dice score in predicting the lesion volume and an RMSE of 0.4854 for temperature distribution when tested with foreseen tumor images. Notably, even with unforeseen images, it achieved a 93% Dice score for the ablation lesion and an RMSE of 0.6783 for temperature distribution. All networks were capable of inferring results within 10 ms. The presented technique, applied to optimize the placement of the electrode for a specific target region, holds significant promise in enhancing the safety and efficacy of RFA treatments.

Falls are a major cause of injuries and deaths among older adults worldwide. Accurate fall detection can help reduce potential injuries and additional health complications. Different types of video modalities can be used in a home setting to detect falls, including RGB, Infrared, and Thermal cameras. Anomaly detection frameworks using autoencoders and their variants can be used for fall detection due to the data imbalance that arises from the rarity and diversity of falls. However, the use of reconstruction error in autoencoders can limit the application of networks' structures that propagate information. In this paper, we propose a new multi-objective loss function called Temporal Shift, which aims to predict both future and reconstructed frames within a window of sequential frames. The proposed loss function is evaluated on a semi-naturalistic fall detection dataset containing multiple camera modalities. The autoencoders were trained on normal activities of daily living (ADL) performed by older adults and tested on ADLs and falls performed by young adults. Temporal shift shows significant improvement to a baseline 3D Convolutional autoencoder, an attention U-Net CAE, and a multi-modal neural network. The greatest improvement was observed in an attention U-Net model improving by 0.20 AUC ROC for a single camera when compared to reconstruction alone. With significant improvement across different models, this approach has the potential to be widely adopted and improve anomaly detection capabilities in other settings besides fall detection.