Post-deployment monitoring of healthcare AI requires statistically valid, label-efficient methods, but gold-standard labels from clinician chart review are expensive. Prediction-powered inference (PPI) and active statistical inference (ASI) reduce label cost by combining a small labeled sample with abundant model predictions, but both are restricted to a single predictor, a poor fit for modern clinical pipelines that have multiple predictors of differing cost and accuracy available at inference time. We propose Active Multiple-Prediction-Powered Inference (AM-PPI), which routes each instance to a cost-appropriate predictor subset, samples gold-standard labels in proportion to the chosen subset's residual uncertainty, and reweights predictions to minimize estimator variance, all under a single deployment-time budget. AM-PPI generalizes ASI to leverage multiple predictors and extends Multiple-PPI from global per-predictor allocation to per-instance adaptive routing. We derive closed-form Karush-Kuhn-Tucker (KKT) conditions for all three decisions and prove, via biconvexity and strong duality, that the resulting fixed point is a global optimum despite the joint problem being non-jointly-convex. We establish asymptotic normality with valid coverage, minimum-variance unbiasedness within the linear-prediction augmented inverse propensity weighted (AIPW) class, and a closed-form criterion identifying when multiple predictors help. On synthetic data and three healthcare monitoring tasks, AM-PPI produces 10 to 40 percent narrower confidence intervals (CIs) than single-predictor ASI in the budget regime where routing matters, and matches the better baseline elsewhere.

Detection of occult hemorrhage (i.e., internal bleeding) in patients in intensive care units (ICUs) can pose significant challenges for critical care workers. Because blood loss may not always be clinically apparent, clinicians rely on monitoring vital signs for specific trends indicative of a hemorrhage event. The inherent difficulties of diagnosing such an event can lead to late intervention by clinicians which has catastrophic consequences. Therefore, a methodology for early detection of hemorrhage has wide utility. We develop a Bayesian regime switching model (RSM) that analyzes trends in patients' vitals and labs to provide a probabilistic assessment of the underlying physiological state that a patient is in at any given time. This article is motivated by a comprehensive dataset we curated from Mayo Clinic of 33,924 real ICU patient encounters. Longitudinal response measurements are modeled as a vector autoregressive process conditional on all latent states up to the current time point, and the latent states follow a Markov process. We present a novel Bayesian sampling routine to learn the posterior probability distribution of the latent physiological states, as well as develop an approach to account for pre-ICU-admission physiological changes. A simulation and real case study illustrate the effectiveness of our approach.

Moreover,inmanysituations,there exist prediction intervals which result in particularly easy-to-predict transitions.

As AI increasingly shapes daily life, energy consumption and data privacy have become pressing concerns. However, the expanding scale of modern neural networks creates a major obstacle for on-device training. Although prior work has concentrated on compact convolutional architectures, we instead apply subspace-based training to transformer models. Motivated by the idea that a model's essential information lies in a fixed subspace, we introduce Weight-Activation Subspace Iteration (W ASI), a method that mitigates the memory bottleneck of backpropagation and boosts inference efficiency in transformer models by restricting training to this subspace. Our results demonstrate that W ASI maintains accuracy comparable to vanilla training while reducing memory usage by up to 62 and computational cost (FLOPs) by up to 2 . On a Raspberry Pi 5, W ASI achieves roughly 1.5 faster training and inference than vanilla training. On-device learning has recently emerged as a promising research direction, enabling deep learning models to be fine-tuned directly on resource-constrained edge devices. This approach addresses critical issues such as privacy and energy consumption, improves scalability, and places control of AI capabilities directly "in user's hands" (Dhar et al., 2021). Prior work on on-device learning has largely focused on vision tasks using convolutional neural network models, primarily because of their compact architectures (Lin et al., 2022; Nguyen et al., 2024; Y ang et al., 2023b; Qu elennec et al., 2024; Bragagnolo et al., 2022; Nguyen et al., 2025). In many real-world applications, however, transformer-based models have become the de facto choice due to their unique architectural mechanisms (V aswani et al., 2017).

Recent surges in LLM-driven intelligent systems largely overlook decades of foundational multi-agent systems (MAS) research, resulting in frameworks with critical limitations such as centralization and inadequate trust and communication protocols. This paper introduces the Fetch.ai architecture, an industrial-strength platform designed to bridge this gap by facilitating the integration of classical MAS principles with modern AI capabilities. We present a novel, multi-layered solution built on a decentralized foundation of on-chain blockchain services for verifiable identity, discovery, and transactions. This is complemented by a comprehensive development framework for creating secure, interoperable agents, a cloud-based platform for deployment, and an intelligent orchestration layer where an agent-native LLM translates high-level human goals into complex, multi-agent workflows. We demonstrate the deployed nature of this system through a decentralized logistics use case where autonomous agents dynamically discover, negotiate, and transact with one another securely. Ultimately, the Fetch.ai stack provides a principled architecture for moving beyond current agent implementations towards open, collaborative, and economically sustainable multi-agent ecosystems.

To succeed in common digital tasks such as web navigation, agents must carry out a variety of specialized tasks such as searching for products or planning a travel route. To tackle these tasks, agents can bootstrap themselves by learning task-specific skills online through interaction with the web environment. In this work, we demonstrate that programs are an effective representation for skills. We propose agent skill induction (ASI), which allows agents to adapt themselves by inducing, verifying, and utilizing program-based skills on the fly. We start with an evaluation on the WebArena agent benchmark and show that ASI outperforms the static baseline agent and its text-skill counterpart by 23.5% and 11.3% in success rate, mainly thanks to the programmatic verification guarantee during the induction phase. ASI also improves efficiency by reducing 10.7-15.3% of the steps over baselines, by composing primitive actions (e.g., click) into higher-level skills (e.g., search product). We then highlight the efficacy of ASI in remaining efficient and accurate under scaled-up web activities. Finally, we examine the generalizability of induced skills when transferring between websites, and find that ASI can effectively reuse common skills, while also updating incompatible skills to versatile website changes.

On-device learning has emerged as a promising direction for AI development, particularly because of its potential to reduce latency issues and mitigate privacy risks associated with device-server communication, while improving energy efficiency. Despite these advantages, significant memory and computational constraints still represent major challenges for its deployment. Drawing on previous studies on low-rank decomposition methods that address activation memory bottlenecks in backpropagation, we propose a novel shortcut approach as an alternative. Our analysis and experiments demonstrate that our method can reduce activation memory usage, even up to $120.09\times$ compared to vanilla training, while also reducing overall training FLOPs up to $1.86\times$ when evaluated on traditional benchmarks.

The recent leap in AI capabilities, driven by big generative models, has sparked the possibility of achieving Artificial General Intelligence (AGI) and further triggered discussions on Artificial Superintelligence (ASI), a system surpassing all humans across all domains. This gives rise to the critical research question of: If we realize ASI, how do we align it with human values, ensuring it benefits rather than harms human society, a.k.a., the Superalignment problem. Despite ASI being regarded by many as solely a hypothetical concept, in this paper, we argue that superalignment is achievable and research on it should advance immediately, through simultaneous and alternating optimization of task competence and value conformity. We posit that superalignment is not merely a safeguard for ASI but also necessary for its realization. To support this position, we first provide a formal definition of superalignment rooted in the gap between capability and capacity and elaborate on our argument. Then we review existing paradigms, explore their interconnections and limitations, and illustrate a potential path to superalignment centered on two fundamental principles. We hope this work sheds light on a practical approach for developing the value-aligned next-generation AI, garnering greater benefits and reducing potential harms for humanity.

As Artificial General Intelligence edges closer to reality, Artificial Superintelligence does too. This paper argues that ASI's unparalleled capabilities might lead people to attribute godlike infallibility to it, resulting in a cognitive bias toward unquestioning acceptance of its decisions. By drawing parallels between ASI and divine attributes such as omnipotence, omniscience, and omnipresence, this analysis highlights the risks of conflating technological advancement with moral and ethical superiority. Such dynamics could engender a technocratic theocracy, where decision-making is abdicated to ASI, undermining human agency and critical thinking.

Existing approaches to Theory of Mind (ToM) in Artificial Intelligence (AI) overemphasize prompted, or cue-based, ToM, which may limit our collective ability to develop Artificial Social Intelligence (ASI). Drawing from research in computer science, cognitive science, and related disciplines, we contrast prompted ToM with what we call spontaneous ToM -- reasoning about others' mental states that is grounded in unintentional, possibly uncontrollable cognitive functions. We argue for a principled approach to studying and developing AI ToM and suggest that a robust, or general, ASI will respond to prompts \textit{and} spontaneously engage in social reasoning.