Autism spectrum disorder (ASD) is a complex neurodevelopmental condition whose rising prevalence places increasing demands on a lengthy diagnostic process. Machine learning (ML) has shown promise in automating ASD diagnosis, but most existing models operate as black boxes and are typically trained on a single dataset, limiting their generalizability. In this study, we introduce a transparent and interpretable ML approach that leverages BioBERT, a state-of-the-art language model, to analyze unstructured clinical text. The model is trained to label descriptions of behaviors and map them to diagnostic criteria, which are then used to assign a final label (ASD or not). We evaluate transfer learning, the ability to transfer knowledge to new data, using two distinct real-world datasets. We trained on datasets sequentially and mixed together and compared the performance of the best models and their ability to transfer to new data. We also created a black-box approach and repeated this transfer process for comparison. Our transparent model demonstrated robust performance, with the mixed-data training strategy yielding the best results (97 % sensitivity, 98 % specificity). Sequential training across datasets led to a slight drop in performance, highlighting the importance of training data order. The black-box model performed worse (90 % sensitivity, 96 % specificity) when trained sequentially or with mixed data. Overall, our transparent approach outperformed the black-box approach. Mixing datasets during training resulted in slightly better performance and should be the preferred approach when practically possible. This work paves the way for more trustworthy, generalizable, and clinically actionable AI tools in neurodevelopmental diagnostics.

ASD is a complicated neurodevelopmental disorder marked by variation in symptom presentation and neurological underpinnings, making early and objective diagnosis extremely problematic. This paper presents a Graph Convolutional Network (GCN) model, incorporating Chebyshev Spectral Graph Convolution and Graph Attention Networks (GAT), to increase the classification accuracy of ASD utilizing multimodal neuroimaging and phenotypic data. Leveraging the ABIDE I dataset, which contains resting-state functional MRI (rs-fMRI), structural MRI (sMRI), and phenotypic variables from 870 patients, the model leverages a multi-branch architecture that processes each modality individually before merging them via concatenation. Graph structure is encoded using site-based similarity to generate a population graph, which helps in understanding relationship connections across individuals. Chebyshev polynomial filters provide localized spectral learning with lower computational complexity, whereas GAT layers increase node representations by attention-weighted aggregation of surrounding information. The proposed model is trained using stratified five-fold cross-validation with a total input dimension of 5,206 features per individual. Extensive trials demonstrate the enhanced model's superiority, achieving a test accuracy of 74.82\% and an AUC of 0.82 on the entire dataset, surpassing multiple state-of-the-art baselines, including conventional GCNs, autoencoder-based deep neural networks, and multimodal CNNs.

Recently, some works integrate SSL techniques into deep clustering frameworks to enhance image clustering performance. However, they all need pretraining, clustering learning, or a trained clustering model as prerequisites, limiting the flexible and out-of-box application of SSL learners in the image clustering task. This work introduces ASD, an adaptor that enables the cold-start of SSL learners for deep image clustering without any prerequisites. Specifically, we first randomly sample pseudo-labeled data from all unlabeled data, and set an instance-level classifier to learn them with semantically aligned instance-level labels. With the ability of instance-level classification, we track the class transitions of predictions on unlabeled data to extract high-level similarities of instance-level classes, which can be utilized to assign cluster-level labels to pseudo-labeled data. Finally, we use the pseudo-labeled data with assigned cluster-level labels to trigger a general SSL learner trained on the unlabeled data for image clustering. We show the superior performance of ASD across various benchmarks against the latest deep image clustering approaches and very slight accuracy gaps compared to SSL methods using ground-truth, e.g., only 1.33% on CIFAR-10. Moreover, ASD can also further boost the performance of existing SSL-embedded deep image clustering methods.

--From dating to job interviews, making new friends or simply chatting with the cashier at checkout, engaging in small talk is a vital, everyday social skill. For adults with Autism Spectrum Disorder (ASD), small talk can be particularly challenging, yet it is essential for social integration, building relationships, and accessing professional opportunities. In this study, we present our development and evaluation of an in-home autonomous robot system that allows users to practice small talk. Results from the week-long study show that adults with ASD enjoyed the training, made notable progress in initiating conversations and improving eye contact, and viewed the system as a valuable tool for enhancing their conversational skills. Imagine a scene where three coworkers are engaging in small talk at the beginning of their workday. One of them is Alex, who has Autism Spectrum Disorder (ASD), a neu-rodevelopmental condition that often makes it challenging to understand and interpret social cues [2]. Not bad... just trying to power through this Monday. How about you, Alex? A: Monday is okay. Anything exciting happen this weekend? B: Y eah, I finally tried that new restaurant. It was fantas-- A: I watched a movie. C: Glad you liked the restaurant, Ben. It's my kids' favorite spot these days... What movie did you watch, Alex? A: "The Martian." At first glance, this brief example of a typical interaction appears unremarkable. It represents the everyday small talk that occurs regularly in many workplaces. For workers with ASD, however, such apparently "easy" interactions may present a real challenge. In this example, while Alex responds to direct questions, the responses are brief and lack elaboration. Alex's responses provide minimal information rather than actively participating in the flow of the conversation. Additionally, Alex's lack of response to the last prompt may suggest difficulty in extending or sustaining the dialogue. Although workers with ASD are often highly trained and skilled in job-specific tasks, they frequently face challenges with social interactions in the workplace.

There is a tradeoff between attaining statistical power with large, difficult to gather data sets, and producing highly scalable assays that register brief data samples. Often, as grand-averaging techniques a priori assume normally-distributed parameters and linear, stationary processes in biorhythmic, time series data, important information is lost, averaged out as gross data. We developed an affective computing platform that enables taking brief data samples while maintaining personalized statistical power. This is achieved by combining a new data type derived from the micropeaks present in time series data registered from brief (5-second-long) face videos with recent advances in AI-driven face-grid estimation methods. By adopting geometric and nonlinear dynamical systems approaches to analyze the kinematics, especially the speed data, the new methods capture all facial micropeaks. These include as well the nuances of different affective micro expressions. We offer new ways to differentiate dynamical and geometric patterns present in autistic individuals from those found more commonly in neurotypical development.

Denoising Diffusion Probabilistic Models (DDPMs) have emerged as powerful tools for generative modeling. However, their sequential computation requirements lead to significant inference-time bottlenecks. In this work, we utilize the connection between DDPMs and Stochastic Localization to prove that, under an appropriate reparametrization, the increments of DDPM satisfy an exchangeability property. This general insight enables near-black-box adaptation of various performance optimization techniques from autoregressive models to the diffusion setting. To demonstrate this, we introduce \emph{Autospeculative Decoding} (ASD), an extension of the widely used speculative decoding algorithm to DDPMs that does not require any auxiliary draft models. Our theoretical analysis shows that ASD achieves a $\tilde{O} (K^{\frac{1}{3}})$ parallel runtime speedup over the $K$ step sequential DDPM. We also demonstrate that a practical implementation of autospeculative decoding accelerates DDPM inference significantly in various domains.

--The prevalence of Autism Spectrum Disorder (ASD) has surged rapidly over the past decade, posing significant challenges in communication, behavior, and focus for affected individuals. Current diagnostic techniques, though effective, are time-intensive, leading to high social and economic costs. This work introduces an AI-powered assistive technology designed to streamline ASD diagnosis and management, enhancing convenience for individuals with ASD and efficiency for caregivers and therapists. The system integrates transfer learning with image transforms derived from eye gaze variables to diagnose ASD. This facilitates and opens opportunities for in-home periodical diagnosis, reducing stress for individuals and caregivers, while also preserving user privacy through the use of image transforms. The accessibility of the proposed method also offers opportunities for improved communication between guardians and therapists, ensuring regular updates on progress and evolving support needs. Overall, the approach proposed in this work ensures timely, accessible diagnosis while protecting the subjects' privacy, improving outcomes for individuals with ASD.

Multimodal Continual Instruction Tuning (MCIT) aims to enable Multimodal Large Language Models (MLLMs) to incrementally learn new tasks without catastrophic forgetting. In this paper, we explore forgetting in this context, categorizing it into superficial forgetting and essential forgetting. Superficial forgetting refers to cases where the model's knowledge may not be genuinely lost, but its responses to previous tasks deviate from expected formats due to the influence of subsequent tasks' answer styles, making the results unusable. By contrast, essential forgetting refers to situations where the model provides correctly formatted but factually inaccurate answers, indicating a true loss of knowledge. Assessing essential forgetting necessitates addressing superficial forgetting first, as severe superficial forgetting can obscure the model's knowledge state. Hence, we first introduce the Answer Style Diversification (ASD) paradigm, which defines a standardized process for transforming data styles across different tasks, unifying their training sets into similarly diversified styles to prevent superficial forgetting caused by style shifts. Building on this, we propose RegLoRA to mitigate essential forgetting. RegLoRA stabilizes key parameters where prior knowledge is primarily stored by applying regularization, enabling the model to retain existing competencies. Experimental results demonstrate that our overall method, SEFE, achieves state-of-the-art performance.

This paper explores the use of Artificial Intelligence (AI) as a tool for diagnosis, assessment, and intervention for individuals with Autism Spectrum Disorder (ASD). It focuses particularly on AI's role in early diagnosis, utilizing advanced machine learning techniques and data analysis. Recent studies demonstrate that deep learning algorithms can identify behavioral patterns through biometric data analysis, video-based interaction assessments, and linguistic feature extraction, providing a more accurate and timely diagnosis compared to traditional methods. Additionally, AI automates diagnostic tools, reducing subjective biases and enabling the development of personalized assessment protocols for ASD monitoring. At the same time, the paper examines AI-powered intervention technologies, emphasizing educational robots and adaptive communication tools. Social robotic assistants, such as NAO and Kaspar, have been shown to enhance social skills in children by offering structured, repetitive interactions that reinforce learning. Furthermore, AI-driven Augmentative and Alternative Communication (AAC) systems allow children with ASD to express themselves more effectively, while machine-learning chatbots provide language development support through personalized responses. The study presents research findings supporting the effectiveness of these AI applications while addressing challenges such as long-term evaluation and customization to individual needs. In conclusion, the paper highlights the significance of AI as an innovative tool in ASD diagnosis and intervention, advocating for further research to assess its long-term impact.