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Global law of conjugate kernel random matrices with heavy-tailed weights
Guionnet, Alice, Piccolo, Vanessa
We study the asymptotic spectral behavior of the conjugate kernel random matrix $YY^\top$, where $Y= f(WX)$ arises from a two-layer neural network model. We consider the setting where $W$ and $X$ are both random rectangular matrices with i.i.d. entries, where the entries of $W$ follow a heavy-tailed distribution, while those of $X$ have light tails. Our assumptions on $W$ include a broad class of heavy-tailed distributions, such as symmetric $\alpha$-stable laws with $\alpha \in (0,2)$ and sparse matrices with $\mathcal{O}(1)$ nonzero entries per row. The activation function $f$, applied entrywise, is nonlinear, smooth, and odd. By computing the eigenvalue distribution of $YY^\top$ through its moments, we show that heavy-tailed weights induce strong correlations between the entries of $Y$, leading to richer and fundamentally different spectral behavior compared to models with light-tailed weights.
DynGFN: Towards Bayesian Inference of Gene Regulatory Networks with GFlowNets
Atanackovic, Lazar, Tong, Alexander, Wang, Bo, Lee, Leo J., Bengio, Yoshua, Hartford, Jason
One of the grand challenges of cell biology is inferring the gene regulatory network (GRN) which describes interactions between genes and their products that control gene expression and cellular function. We can treat this as a causal discovery problem but with two non-standard challenges: (1) regulatory networks are inherently cyclic so we should not model a GRN as a directed acyclic graph (DAG), and (2) observations have significant measurement noise, so for typical sample sizes there will always be a large equivalence class of graphs that are likely given the data, and we want methods that capture this uncertainty. Existing methods either focus on challenge (1), identifying cyclic structure from dynamics, or on challenge (2) learning complex Bayesian posteriors over DAGs, but not both. In this paper we leverage the fact that it is possible to estimate the "velocity" of gene expression with RNA velocity techniques to develop an approach that addresses both challenges. Because we have access to velocity information, we can treat the Bayesian structure learning problem as a problem of sparse identification of a dynamical system, capturing cyclic feedback loops through time. Since our objective is to model uncertainty over discrete structures, we leverage Generative Flow Networks (GFlowNets) to estimate the posterior distribution over the combinatorial space of possible sparse dependencies. Our results indicate that our method learns posteriors that better encapsulate the distributions of cyclic structures compared to counterpart state-of-the-art Bayesian structure learning approaches.
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Flow-Based Algorithms for Local Graph Clustering
Orecchia, Lorenzo, Zhu, Zeyuan Allen
Given a subset S of vertices of an undirected graph G, the cut-improvement problem asks us to find a subset S that is similar to A but has smaller conductance. A very elegant algorithm for this problem has been given by Andersen and Lang [AL08] and requires solving a small number of single-commodity maximum flow computations over the whole graph G. In this paper, we introduce LocalImprove, the first cut-improvement algorithm that is local, i.e. that runs in time dependent on the size of the input set A rather than on the size of the entire graph. Moreover, LocalImprove achieves this local behaviour while essentially matching the same theoretical guarantee as the global algorithm of Andersen and Lang. The main application of LocalImprove is to the design of better local-graph-partitioning algorithms. All previously known local algorithms for graph partitioning are random-walk based and can only guarantee an output conductance of O(\sqrt{OPT}) when the target set has conductance OPT \in [0,1]. Very recently, Zhu, Lattanzi and Mirrokni [ZLM13] improved this to O(OPT / \sqrt{CONN}) where the internal connectivity parameter CONN \in [0,1] is defined as the reciprocal of the mixing time of the random walk over the graph induced by the target set. In this work, we show how to use LocalImprove to obtain a constant approximation O(OPT) as long as CONN/OPT = Omega(1). This yields the first flow-based algorithm. Moreover, its performance strictly outperforms the ones based on random walks and surprisingly matches that of the best known global algorithm, which is SDP-based, in this parameter regime [MMV12]. Finally, our results show that spectral methods are not the only viable approach to the construction of local graph partitioning algorithm and open door to the study of algorithms with even better approximation and locality guarantees.
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