Precise image segmentation provides clinical study with instructive information. Despite the remarkable progress achieved in medical image segmentation, there is still an absence of a 3D foundation segmentation model that can segment a wide range of anatomical categories with easy user interaction. In this paper, we propose a 3D foundation segmentation model, named SegVol, supporting universal and interactive volumetric medical image segmentation. By scaling up training data to 90K unlabeled Computed Tomography (CT) volumes and 6K labeled CT volumes, this foundation model supports the segmentation of over 200 anatomical categories using semantic and spatial prompts. To facilitate efficient and precise inference on volumetric images, we design a zoom-out-zoom-in mechanism. Extensive experiments on 22 anatomical segmentation tasks verify that SegVol outperforms the competitors in 19 tasks, with improvements up to 37.24% compared to the runner-up methods. We demonstrate the effectiveness and importance of specific designs by ablation study. We expect this foundation model can promote the development of volumetric medical image analysis.

When we take photos through glass windows or doors, the transmitted background scene is often blended with undesirable reflection. Separating two layers apart to enhance the image quality is of vital importance for both human and machine perception. In this paper, we propose to exploit physical constraints from a pair of unpolarized and polarized images to separate reflection and transmission layers. Due to the simplified capturing setup, the system becomes more underdetermined compared with existing polarization based solutions that take three or more images as input. We propose to solve semireflector orientation estimation first to make the physical image formation well-posed and then learn to reliably separate two layers using a refinement network with gradient loss. Quantitative and qualitative experimental results show our approach performs favorably over existing polarization and single image based solutions.

Automatically generating novel and interesting games is a complex task. Challenges include representing game rules in a computationally workable form, searching through the large space of potential games under most such representations, and accurately evaluating the originality and quality of previously unseen games. Prior work in automated game generation has largely focused on relatively restricted rule representations and relied on domain-specific heuristics. In this work, we explore the generation of novel games in the comparatively expansive Ludii game description language, which encodes the rules of over 1000 board games in a variety of styles and modes of play. We draw inspiration from recent advances in large language models and evolutionary computation in order to train a model that intelligently mutates and recombines games and mechanics expressed as code. We demonstrate both quantitatively and qualitatively that our approach is capable of generating new and interesting games, including in regions of the potential rules space not covered by existing games in the Ludii dataset. A sample of the generated games are available to play online through the Ludii portal.

AI model alignment is crucial due to inadvertent biases in training data and the underspecified machine learning pipeline, where models with excellent test metrics may not meet end-user requirements. While post-training alignment via human feedback shows promise, these methods are often limited to generative AI settings where humans can interpret and provide feedback on model outputs. In traditional non-generative settings with numerical or categorical outputs, detecting misalignment through single-sample outputs remains challenging, and enforcing alignment during training requires repeating costly training processes. In this paper we consider an alternative strategy. We propose interpreting model alignment through property testing, defining an aligned model f as one belonging to a subset P of functions that exhibit specific desired behaviors.

No code was provided: Code for toy simulations was actually provided in the supplementary materials.

Given a huge set of applicants, how should a firm allocate sequential resume screenings, phone interviews, and in-person site visits? In a tiered interview process, later stages (e.g., in-person visits) are more informative, but also more expensive than earlier stages (e.g., resume screenings). Using accepted hiring models and the concept of structured interviews, a best practice in human resources, we cast tiered hiring as a combinatorial pure exploration (CPE) problem in the stochastic multi-armed bandit setting. The goal is to select a subset of arms (in our case, applicants) with some combinatorial structure. We present new algorithms in both the probably approximately correct (PAC) and fixed-budget settings that select a near-optimal cohort with provable guarantees. We show via simulations on real data from one of the largest US-based computer science graduate programs that our algorithms make better hiring decisions or use less budget than the status quo. '... nothing we do is more important than hiring and developing people. At the end of the day, you bet on people, not on strategies." - Lawrence Bossidy, The CEO as Coach (1995)

Predicting molecular impact on cellular function is a core challenge in therapeutic design. Phenomic experiments, designed to capture cellular morphology, utilize microscopy based techniques and demonstrate a high throughput solution for uncovering molecular impact on the cell. In this work, we learn a joint latent space between molecular structures and microscopy phenomic experiments, aligning paired samples with contrastive learning. Specifically, we study the problem of Contrastive PhenoMolecular Retrieval, which consists of zero-shot molecular structure identification conditioned on phenomic experiments. We assess challenges in multi-modal learning of phenomics and molecular modalities such as experimental batch effect, inactive molecule perturbations, and encoding perturbation concentration.

Natural images captured by mobile devices often suffer from multiple types of degradation, such as noise, blur, and low light. Traditional image restoration methods require manual selection of specific tasks, algorithms, and execution sequences, which is time-consuming and may yield suboptimal results. All-in-one models, though capable of handling multiple tasks, typically support only a limited range and often produce overly smooth, low-fidelity outcomes due to their broad data distribution fitting. To address these challenges, we first define a new pipeline for restoring images with multiple degradations, and then introduce RestoreAgent, an intelligent image restoration system leveraging multimodal large language models. RestoreAgent autonomously assesses the type and extent of degradation in input images and performs restoration through (1) determining the appropriate restoration tasks, (2) optimizing the task sequence, (3) selecting the most suitable models, and (4) executing the restoration. Experimental results demonstrate the superior performance of RestoreAgent in handling complex degradation, surpassing human experts.

Out-of-Distribution (OOD) generalization in machine learning is a burgeoning area of study. Its primary goal is to enhance the adaptability and resilience of machine learning models when faced with new, unseen, and potentially adversarial data that significantly diverges from their original training datasets. In this paper, we investigate time series OOD generalization via pre-trained Large Language Models (LLMs). We first propose a novel Tri-level learning framework for Time Series OOD generalization, termed TTSO, which considers both sample-level and group-level uncertainties. This formula offers a fresh theoretic perspective for formulating and analyzing OOD generalization problem. In addition, we provide a theoretical analysis to justify this method is well motivated. We then develop a stratified localization algorithm tailored for this tri-level optimization problem, theoretically demonstrating the guaranteed convergence of the proposed algorithm.

Meta-Reinforcement Learning (Meta-RL) agents can struggle to operate across tasks with varying environmental features that require different optimal skills (i.e., different modes of behaviour). Using context encoders based on contrastive learning to enhance the generalisability of Meta-RL agents is now widely studied but faces challenges such as the requirement for a large sample size, also referred to as the log-K curse. To improve RL generalisation to different tasks, we first introduce Skill-aware Mutual Information (SaMI), an optimisation objective that aids in distinguishing context embeddings according to skills, thereby equipping RL agents with the ability to identify and execute different skills across tasks. We then propose Skill-aware Noise Contrastive Estimation (SaNCE), a K-sample estimator used to optimise the SaMI objective. We provide a framework for equipping an RL agent with SaNCE in practice and conduct experimental validation on modified MuJoCo and Panda-gym benchmarks. We empirically find that RL agents that learn by maximising SaMI achieve substantially improved zero-shot generalisation to unseen tasks. Additionally, the context encoder trained with SaNCE demonstrates greater robustness to a reduction in the number of available samples, thus possessing the potential to overcome the log-K curse.