Multimodal electronic health record (EHR) data can offer a holistic assessment of a patient's health status, supporting various predictive healthcare tasks. Recently, several studies have embraced the multitask learning approach in the healthcare domain, exploiting the inherent correlations among clinical tasks to predict multiple outcomes simultaneously. However, existing methods necessitate samples to possess complete labels for all tasks, which places heavy demands on the data and restricts the flexibility of the model. Meanwhile, within a multitask framework with multimodal inputs, how to comprehensively consider the information disparity among modalities and among tasks still remains a challenging problem. To tackle these issues, a unified healthcare prediction model, also named by \textbf{FlexCare}, is proposed to flexibly accommodate incomplete multimodal inputs, promoting the adaption to multiple healthcare tasks. The proposed model breaks the conventional paradigm of parallel multitask prediction by decomposing it into a series of asynchronous single-task prediction. Specifically, a task-agnostic multimodal information extraction module is presented to capture decorrelated representations of diverse intra- and inter-modality patterns. Taking full account of the information disparities between different modalities and different tasks, we present a task-guided hierarchical multimodal fusion module that integrates the refined modality-level representations into an individual patient-level representation. Experimental results on multiple tasks from MIMIC-IV/MIMIC-CXR/MIMIC-NOTE datasets demonstrate the effectiveness of the proposed method. Additionally, further analysis underscores the feasibility and potential of employing such a multitask strategy in the healthcare domain. The source code is available at https://github.com/mhxu1998/FlexCare.

Temporal graph learning aims to generate high-quality representations for graph-based tasks along with dynamic information, which has recently drawn increasing attention. Unlike the static graph, a temporal graph is usually organized in the form of node interaction sequences over continuous time instead of an adjacency matrix. Most temporal graph learning methods model current interactions by combining historical information over time. However, such methods merely consider the first-order temporal information while ignoring the important high-order structural information, leading to sub-optimal performance. To solve this issue, by extracting both temporal and structural information to learn more informative node representations, we propose a self-supervised method termed S2T for temporal graph learning. Note that the first-order temporal information and the high-order structural information are combined in different ways by the initial node representations to calculate two conditional intensities, respectively. Then the alignment loss is introduced to optimize the node representations to be more informative by narrowing the gap between the two intensities. Concretely, besides modeling temporal information using historical neighbor sequences, we further consider the structural information from both local and global levels. At the local level, we generate structural intensity by aggregating features from the high-order neighbor sequences. At the global level, a global representation is generated based on all nodes to adjust the structural intensity according to the active statuses on different nodes. Extensive experiments demonstrate that the proposed method S2T achieves at most 10.13% performance improvement compared with the state-of-the-art competitors on several datasets.

Stochastic optimization methods such as mirror descent have wide applications due to low computational cost. Those methods have been well studied under assumption of the independent and identical distribution, and usually achieve sublinear rate of convergence. However, this assumption may be too strong and unpractical in real application scenarios. Recent researches investigate stochastic gradient descent when instances are sampled from a Markov chain. Unfortunately, few results are known for stochastic mirror descent. In the paper, we propose a new version of stochastic mirror descent termed by MarchOn in the scenario of the federated learning. Given a distributed network, the model iteratively travels from a node to one of its neighbours randomly. Furthermore, we propose a new framework to analyze MarchOn, which yields best rates of convergence for convex, strongly convex, and non-convex loss. Finally, we conduct empirical studies to evaluate the convergence of MarchOn, and validate theoretical results.

Although data-driven methods usually have noticeable performance on disease diagnosis and treatment, they are suspected of leakage of privacy due to collecting data for model training. Recently, federated learning provides a secure and trustable alternative to collaboratively train model without any exchange of medical data among multiple institutes. Therefore, it has draw much attention due to its natural merit on privacy protection. However, when heterogenous medical data exists between different hospitals, federated learning usually has to face with degradation of performance. In the paper, we propose a new personalized framework of federated learning to handle the problem. It successfully yields personalized models based on awareness of similarity between local data, and achieves better tradeoff between generalization and personalization than existing methods. After that, we further design a differentially sparse regularizer to improve communication efficiency during procedure of model training. Additionally, we propose an effective method to reduce the computational cost, which improves computation efficiency significantly. Furthermore, we collect 5 real medical datasets, including 2 public medical image datasets and 3 private multi-center clinical diagnosis datasets, and evaluate its performance by conducting nodule classification, tumor segmentation, and clinical risk prediction tasks. Comparing with 13 existing related methods, the proposed method successfully achieves the best model performance, and meanwhile up to 60% improvement of communication efficiency. Source code is public, and can be accessed at: https://github.com/ApplicationTechnologyOfMedicalBigData/pFedNet-code.

For any i such that 1 i 6, A i represents an instance of the dataset, X i represents the corresponding optimization variable, v i represents a vertex of graph G, and e ij represents the edge connecting v i and v j. heuristic rules used in traditional clustering methods. A formulation of convex clustering was proposed in [13] by relaxing the formulation of k-means clustering. Subsequently, [15] and [16] provided several sufficient conditions for recovering the clustering membership theoretically . Other studies, e.g., [8], [17], focus on improving the efficiency of convex clustering. Although those previous studies attained great improvement of convex clustering for static datasets, they are unsuitable for handling evolving datasets due to a high computational cost. The method proposed in the paper reduces such computational cost and makes a good tradeoff between efficiency and accuracy .

Decentralized Online Learning (online learning in decentralized networks) attracts more and more attention, since it is believed that Decentralized Online Learning can help the data providers cooperatively better solve their online problems without sharing their private data to a third party or other providers. Typically, the cooperation is achieved by letting the data providers exchange their models between neighbors, e.g., recommendation model. However, the best regret bound for a decentralized online learning algorithm is $\Ocal{n\sqrt{T}}$, where $n$ is the number of nodes (or users) and $T$ is the number of iterations. This is clearly insignificant since this bound can be achieved \emph{without} any communication in the networks. This reminds us to ask a fundamental question: \emph{Can people really get benefit from the decentralized online learning by exchanging information?} In this paper, we studied when and why the communication can help the decentralized online learning to reduce the regret. Specifically, each loss function is characterized by two components: the adversarial component and the stochastic component. Under this characterization, we show that decentralized online gradient (DOG) enjoys a regret bound $\Ocal{n\sqrt{T}G + \sqrt{nT}\sigma}$, where $G$ measures the magnitude of the adversarial component in the private data (or equivalently the local loss function) and $\sigma$ measures the randomness within the private data. This regret suggests that people can get benefits from the randomness in the private data by exchanging private information. Another important contribution of this paper is to consider the dynamic regret -- a more practical regret to track users' interest dynamics. Empirical studies are also conducted to validate our analysis.

We provide a new theoretical analysis framework to investigate online gradient descent in the dynamic environment. Comparing with the previous work, the new framework recovers the state-of-the-art dynamic regret, but does not require extra gradient queries for every iteration. Specifically, when functions are $\alpha$ strongly convex and $\beta$ smooth, to achieve the state-of-the-art dynamic regret, the previous work requires $O(\kappa)$ with $\kappa = \frac{\beta}{\alpha}$ queries of gradients at every iteration. But, our framework shows that the query complexity can be improved to be $O(1)$, which does not depend on $\kappa$. The improvement is significant for ill-conditioned problems because that their objective function usually has a large $\kappa$.

In online learning, the dynamic regret metric chooses the reference (optimal) solution that may change over time, while the typical (static) regret metric assumes the reference solution to be constant over the whole time horizon. The dynamic regret metric is particularly interesting for applications such as online recommendation (since the customers' preference always evolves over time). While the online gradient method has been shown to be optimal for the static regret metric, the optimal algorithm for the dynamic regret remains unknown. In this paper, we show that proximal online gradient (a general version of online gradient) is optimum to the dynamic regret by showing that the proved lower bound matches the upper bound that slightly improves existing upper bound.

Recently, network lasso has drawn many attentions due to its remarkable performance on simultaneous clustering and optimization. However, it usually suffers from the imperfect data (noise, missing values etc), and yields sub-optimal solutions. The reason is that it finds the similar instances according to their features directly, which is usually impacted by the imperfect data, and thus returns sub-optimal results. In this paper, we propose triangle lasso to avoid its disadvantage. Triangle lasso finds the similar instances according to their neighbours. If two instances have many common neighbours, they tend to become similar. Although some instances are profiled by the imperfect data, it is still able to find the similar counterparts. Furthermore, we develop an efficient algorithm based on Alternating Direction Method of Multipliers (ADMM) to obtain a moderately accurate solution. In addition, we present a dual method to obtain the accurate solution with the low additional time consumption. We demonstrate through extensive numerical experiments that triangle lasso is robust to the imperfect data. It usually yields a better performance than the state-of-the-art method when performing data analysis tasks in practical scenarios.